591-09-3Relevant articles and documents
Cyclic diamine compounds and medicine containing the same
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, (2008/06/13)
The present invention offers novel cyclic diamine compounds and a pharmaceutical composition containing the same. The present invention relates to a compound represented by the formula (I) or salt(s) or solvate(s) thereof. (In the formula, is an optionally substituted divalent residue of benzene, pyridine, cyclohexane or naphthalene or is a vinylene group where Ar is an optionally substituted aryl group;X is —NH—, oxygen atom or sulfur atom;Y is —NR1—, oxygen atom, sulfur atom, sulfoxide or sulfone;Z is a single bond or —NR2—;R1 is hydrogen atom, optionally substituted lower alkyl group, optionally substituted aryl group or optionally substituted silyl lower alkyl group;R2 is hydrogen atom, optionally substituted lower alkyl group, optionally substituted aryl group or optionally substituted silyl lower alkyl group;l is an integer of from 0 to 15;m is an integer of 2 or 3; andn is an integer of from 0 to 3). The compound of the present invention is useful as a pharmaceutical composition, particuarly as an inhibitor of acyl coenzyme A cholesterol acyltransferase (ACAT).
Linear-Reactor-IR.-Matrix and Microwave Spectroscopy of the System O3/NO2/(Z)-2-Butene
Dommen, Joseph,Forster, Martin,Rupreccht, Heidi,Bauder, Alfred,Guenthard, Hans-Heinrich
, p. 504 - 520 (2007/10/02)
Investigation of the formation of complex reaction products in the gas-phase system O3/NO2/(Z)-2-butene by combination of linear reactors with IR. matrix and microwave Stark spectroscopy is reported.Besides the polyatomic products observed earlier in the gas-phase ozonolysis of (Z)-2-butene, the following products were identified: N2O5, HNO3, HNO4, CH3NO2, CH3ONO, CH3COONO2 and CH3COO2NO2 (peroxyacetyl nitrate PAN).Matrix IR spectra of N2O5, HNO3, CH3COONO, CH3COONO2 required for reference purposes are presented.It is shown that PAN-formation occurs already in the absence of light.A reaction scheme is proposed for explanation of the observed complex NOx-containing products, which assumes methyldioxirane as a central intermediate.Particular reaction steps of the scheme will be discussed, including thermochemical estimates of reaction enthalpies.