59142-47-1

Basic information

• Product Name: (2-BROMOPHENYL)(PHENYL)METHANOL
• Synonyms: (2-BROMOPHENYL)(PHENYL)METHANOL
• CAS NO: 59142-47-1
• Molecular Formula: C₁₃H₁₁BrO
• Molecular Weight: 263.13
• Mol File: 59142-47-1.mol
• Article Data: 62

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-BROMOPHENYL)(PHENYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (2-BROMOPHENYL)(PHENYL)METHANOL(59142-47-1)
• EPA Substance Registry System: (2-BROMOPHENYL)(PHENYL)METHANOL(59142-47-1)

Safety Data

• Hazardous Substances Data: 59142-47-1(Hazardous Substances Data)

Usage

General Description

(2-BROMOPHENYL)(PHENYL)METHANOL, also known as 2-bromo-1-(phenylmethyl)benzene, is a chemical compound with the molecular formula C13H11BrO. It is a pale yellow to brown crystalline solid that is used as a building block in organic synthesis and pharmaceutical research. (2-BROMOPHENYL)(PHENYL)METHANOL contains both a bromine atom and a hydroxyl group attached to a benzene ring, making it a valuable intermediate in the production of various pharmaceuticals and agrochemicals. Its unique structure and reactivity make it an important compound for the creation of diverse chemical products and solutions.

Upstream product

• 95953-74-5 1,2-bis-(2-bromo-phenyl)-1,2-diphenyl-ethane-1,2-diol 
• 103-73-1 Phenetole 
• 583-55-1 1-Bromo-2-iodobenzene 
• 100-52-7 benzaldehyde 
• 960-71-4 triphenylborane 
• 6630-33-7 ortho-bromobenzaldehyde 
• 123335-02-4 bis-(2-bromophenyl)methanol 
• 18982-54-2 o-bromobenzyl alcohol 
• 591-50-4 iodobenzene 
• 591-51-5 phenyllithium 
• 100-59-4 phenylmagnesium chloride 
• 108-86-1 bromobenzene 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 3262-89-3 triphenylboroxine 

Downstream Products

• 13047-06-8 o-bromobenzophenone 
• 5398-11-8 3-phenylphthalide 
• 192521-16-7 2-bromobenzhydryl chloride 
• 174671-49-9 1,3-dihydro-1-hydroxy-3-phenyl-2,1-benzoxaborole 
• 245432-28-4 (R)-(2-bromophenyl)(phenyl)methanol 
• 143880-86-8 (S)-o-bromobenzhydrol 
• 59142-29-9 1'-methyl-3-phenyl-3H-spiro[isobenzofuran-1,4'-piperidine] 
• 59142-71-1 1-bromo-2-[methoxy(phenyl)methyl]-benzene 
• 119-61-9 benzophenone 
• 486-25-9 9-fluorenone 
• 1985-32-6 2-phenylbenzophenone 
• 1379534-67-4 C₂₁H₂₈OSi₂ 
• 1379534-77-6 C₂₁H₂₈OSi₂ 
• 1612839-79-8 2-(4-methoxyphenyl)-4-phenylphthalazin-1(2H)-one 

Relevant articles and documents

The intramolecular reaction of acetophenoneN-tosylhydrazone and vinyl: Br?nsted acid-promoted cationic cyclization toward polysubstituted indenes

In the presence of TsNHNH2, a Br?nsted acid-promoted intramolecular cyclization ofo-(1-arylvinyl) acetophenone derivatives was developed, leading to polysubstituted indenes with complexity and diversity in moderate to excellent yields. In sharp contrast with either the radical or carbene involved cyclization of aldehydicN-tosylhydrazone with vinyl, a cationic cyclization pathway was involved, whereN-tosylhydrazone served as an electrophile and alkylation reagent during this transformation.

Highly Enantioselective Cobalt-Catalyzed Hydroboration of Diaryl Ketones

A highly enantioselective cobalt-catalyzed hydroboration of diaryl ketones with pinacolborane was developed using chiral imidazole iminopyridine as a ligand to access chiral benzhydrols in good to excellent yields and ee. This protocol could be carried out in a gram scale under mild reaction conditions with good functional group tolerance. Chiral biologically active 3-substituted phthalide and (S)-neobenodine could be easily constructed through asymmetric hydroboration as a key step.

Asymmetric Synthesis of 1,2-Dihydronaphthalene-1-ols via Copper-Catalyzed Intramolecular Reductive Cyclization

We describe a copper-catalyzed intramolecular reductive cyclization of easily accessible benz-tethered 1,3-dienes containing a ketone moiety. This process provided biologically active 1,2-dihydronaphthalene-1-ol derivatives in good yields with excellent enantio- and diastereoselectivity. Mechanistic investigations using density functional theory revealed that (Z)- and (E)-allylcopper intermediates formed in situ from the diene and copper catalyst undergo isomerization and selective intramolecular allylation of the (E)-allylcopper form of the major product through a six-membered boatlike transition state. The resulting products were further transformed to fully saturated naphthalene-1-ols by reactions of the olefin moiety.