59363-13-2Relevant articles and documents
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Walker et al.
, p. 840 (1978)
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A industrialized butoconazole nitrate intermediates (by machine translation)
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Paragraph 0067-0069, (2018/04/02)
The invention relates to a kind of industrial production butoconazole nitrate intermediate 1 - (2 - hydroxy - 4 - (4 - chlorophenyl) butyl) - 1 - imidazole method of hydrogen. The method comprises the following steps: (1) taking sodium hydride DMF solution, under the condition of the ice, slow instillment imidazole DMF solution, heating and stirring the reaction; after cooling, slowly adding 1 - chloro - 4 - (4 - chlorophenyl) - 2 - butanol, heating and stirring the reaction, after cooling, to the reaction solution; (2) taking the steps of (1) the resulting reaction solution, under the condition of stirring and mixing ice, to stop the precipitate is filtered, washing the filter cake, drying, recrystallization, to get the. The method of the invention the synthetic process conditions and parameters in the comprehensive preferably, and improves product purity and yield, more suitable for large-scale industrial production. (by machine translation)
A industrialized production butoconazole nitrate intermediates
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Paragraph 0075-0077, (2018/05/24)
The invention relates to a method for industrially producing a butoconazole nitrate intermediate 1-(2-chloro-4-(4-chlorphenyl)butyl)-1-hydro-imidazole. The method comprises the following steps: (1) taking 1-(2-hydroxy-4-(4-chlorphenyl)butyl)-1-hydro-imidazole and thionyl chloride as raw materials to undergo heating reflux in dichloromethane, and after full reaction, cooling the reactant, thus obtaining a reaction liquid; and (2) slowly adding cold water and anhydrous sodium carbonate to the reaction liquid obtained in the step (1) in sequence, carrying out suction filtration, discarding the solid, concentrating the liquid and drying the concentrate, thus obtaining the butoconazole nitrate intermediate. In the method provided by the invention, the conditions and parameters in the synthetic process are comprehensively and preferentially selected, thus increasing the purity and yield of the product. Therefore, the method is more suitable for large-scale industrial production.