59681-66-2

Basic information

• Product Name: 4-Chloro-N1-methylbenzene-1,2-diamine
• Synonyms: 4-Chloro-N1-methylbenzene-1,2-diamine;4-chloro-N1-methyl-1,2-Benzenediamine
• CAS NO: 59681-66-2
• Molecular Formula: C₇H₉ClN₂
• Molecular Weight: 156.61276
• Mol File: 59681-66-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 309.5±27.0 °C(Predicted)
• Appearance: /
• Density: 1.272±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 5.49±0.11(Predicted)
• CAS DataBase Reference: 4-Chloro-N1-methylbenzene-1,2-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-N1-methylbenzene-1,2-diamine(59681-66-2)
• EPA Substance Registry System: 4-Chloro-N1-methylbenzene-1,2-diamine(59681-66-2)

Safety Data

• Hazardous Substances Data: 59681-66-2(Hazardous Substances Data)

Usage

General Description

4-Chloro-N1-methylbenzene-1,2-diamine, also known as 4-Chloro-2-methylaniline, is a chemical compound with the molecular formula C7H9ClN2. It is a derivative of benzene and is commonly used in the production of dyes, pharmaceuticals, and other organic compounds. This chemical is primarily used as an intermediate in the synthesis of various products, including pigments, textiles, and hair dyes. It is important to handle this chemical with caution, as it can be harmful if ingested, inhaled, or comes into contact with the skin or eyes. Additionally, it may pose a risk to the environment and should be properly disposed of according to local regulations.

Upstream product

• 15950-17-1 4-chloro-N-methyl-2-nitroaniline 
• 74-89-5 methylamine 
• 89-61-2 2,5-dichloronitrobenzene 
• 89-63-4 4-Chloro-2-nitroaniline 
• 345-18-6 2-fluoro-5-chloronitrobenzene 

Downstream Products

• 30064-10-9 5-chloro-1-methyl-2-trifluoromethylbenzimidazole 
• 690231-88-0 2-chloro-N-(5-chloro-2-methylamino-phenyl)-5-nitro-benzamide 
• 380177-22-0 (N-methyl-5-chloro-1H-benzimidazole-2-yl)methanol 
• 1191924-13-6 C₂₁H₁₆Cl₃N₅ 
• 103748-25-0 5-chloro-1-methyl-1H-benzimidazol-2-amine 
• 107917-65-7 3-(2-aminophenyl)-6-chloro-1-methylquinoxalin-2(1H)-one 
• 690231-93-7 5-chloro-2-(2-chloro-5-nitro-phenyl)-1-methyl-1H-benzoimidazole 
• 423755-06-0 4-chloro-3-(5-chloro-1-methyl-1H-benzoimidazol-2-yl)-phenylamine 
• 26960-04-3 5-chloro-1,2-dimethyl-1H-benzimidazole 
• 15965-71-6 5-chloro-1,3-dihydro-1-methyl-2H-benzimidazol-2-one 
• 37385-92-5 5-chloro-1-methyl-3-phenyl-1,3-dihydro-2H-benzo[d]imidazol-2-one 
• 22316-47-8 clobazam 

Relevant articles and documents

Cu-Catalyzed C-H Allylation of Benzimidazoles with Allenes

CuH-catalyzed intramolecular cyclization and intermolecular allylation of benzimidazoles with allenes have been described. The reaction proceeded smoothly with the catalytic system of Cu(OAc)2/Xantphos and catalytic amount of (MeO)2MeSiH. This protocol features mild reaction conditions and a good tolerance of substrates bearing electron-withdrawing, electron-donating, or electron-neutral groups. A new catalytic mechanism was proposed for this copper hydride catalytic system.

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

The discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly is described. Synthesis of analogs of the 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione hit established structure-activity relationships. Replacement of the enamine functionality of the hit series with either an imidazole or a pyrazole ring led to compounds that inhibited both capsid assembly and reverse transcriptase. Optimization of the bicyclic benzodiazepine scaffold to include a 3-phenyl substituent led to lead compound 48, a pure capsid assembly inhibitor with improved antiviral activity.