59813-05-7

Basic information

• Product Name: piperazine dihydrobromide
• Synonyms: piperazine dihydrobromide;Piperazine-1,4-diium bromide
• CAS NO: 59813-05-7
• Molecular Formula: 2Br*C₄H₁₂N₂
• Molecular Weight: 247.95948
• EINECS: 261-937-0
• Mol File: 59813-05-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 360°C(dec.)(lit.)
• Boiling Point: 149.3°C at 760 mmHg
• Flash Point: 49.7°C
• Appearance: /
• Vapor Pressure: 4.05mmHg at 25°C
• Water Solubility: Soluble in water
• CAS DataBase Reference: piperazine dihydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: piperazine dihydrobromide(59813-05-7)
• EPA Substance Registry System: piperazine dihydrobromide(59813-05-7)

Safety Data

• Hazardous Substances Data: 59813-05-7(Hazardous Substances Data)

Usage

General Description

Piperazine dihydrobromide is a chemical compound that is commonly used in pharmaceuticals and veterinary products as an anthelmintic agent, meaning it is used to treat infections caused by parasitic worms. It works by paralyzing the parasites, making it easier for the body to eliminate them. Piperazine dihydrobromide is also used as a corrosion inhibitor in cooling and heating systems, as well as a curing agent in epoxy resins. It is a white crystalline powder that is soluble in water and has a low toxicity profile. However, it should be handled with care and used in accordance with safety guidelines, as excessive exposure can cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C4H10N2.2BrH/c1-2-6-4-3-5-1;;/h5-6H,1-4H2;2*1H

Upstream product

• 110-85-0 piperazine 
• 10035-10-6 hydrogen bromide 
• 5450-74-8 1,4-dimethyl-1,4-diazabicyclo[2.2.2]octane-1,4-diium dibromide 

Relevant articles and documents

Synthesis and characterization of a new acid molten salt and the study of its thermal behavior and catalytic activity in Fischer esterification

A new acid molten salt was prepared and its structure elucidation was conducted by FTIR, 1D NMR, 2D NMR, and mass spectrometry. Further support to elucidate the chemical structure of the 1H,4H-piperazine-N,N′-diium ring of the new acid molten salt was achieved by1H and13C NMR, and COSY analyses of 1H,4H-piperazine-N,N′-diium dibromide, which is synthesized and characterized for the first time in the current work. The analysis of FTIR and NMR spectra as well as pH and titrimetric analysis excluded the formation of [SO4]2?and the presence of an excess of H2SO4. Moreover, no distinguishing peak was detected for the acid proton of [HSO4]?in DMSO-d6. The thermal phase transition and thermal stability of the acid molten salt were also recorded, which approved the strong interaction between a dication and hydrogen sulfate anions. According to the acidity of the new molten salt, we encourage the study of its catalytic activity for the acetylation ofn-pentanol using glacial acetic acid. Pentyl acetate was obtained in 89.0% conversion and 78.0% isolated yield. The1H NMR spectrum of the residue showed an excess of HOAc together with molten salt, whereas the1H NMR spectrum of the upper phase exhibited pure pentyl acetate. After separation of the upper phase, the residue was concentrated and used in the next run without further purification. No significant changes in the chemical structure and catalytic activity of the new molten salt were observed even after the 5th run. Two chiral alcohols, including (?)-menthol and (+)-borneol, as well as α-tocopherol (α-TCP) were also acetylated with acetic acid in the presence of the new acid molten salt under optimized reaction conditions, which afforded the desired acetates in high yields.

Initiation of Piperazine Ring Formation by Formaldehyde in Its Reaction with Nickel(II) N-(2-Aminoethyl)aziridine and N-(2-Haloethyl)ethylenediamine Complexes

Reaction of [NiL2X2] (L′ = N-(2-haloethyl)ethylenediamine and L″ = N-(2-aminoethyl)aziridine; X = Cl, Br) with formaldehyde in methanol is studied. The major final products of the reaction with [NiL′2X2] are piperazine dihydrohalides and with [NiL″2X2], polymethylenepiperazine. Formally, formaldehyde does not participate in the first reaction. Possible reaction pathways explaining formaldehyde-induced formation of the piperazine ring are discussed.