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Cas Database

59935-29-4

59935-29-4

Identification

  • Product Name:H-[15N]VAL-OH

  • CAS Number: 59935-29-4

  • EINECS:

  • Molecular Weight:118.141

  • Molecular Formula: C5H11NO2

  • HS Code:28459000

  • Mol File:59935-29-4.mol

Synonyms:15N-Valine;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
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  • Purchase
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:L-Valine-15N 98 atom %
  • Packaging:500mg
  • Price:$ 243
  • Delivery:In stock
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:L-Valine-15N
  • Packaging:0.1 g
  • Price:$ 675
  • Delivery:In stock
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:L-Valine-15N
  • Packaging:1 g
  • Price:$ 1500
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:L-VALINE-15N 95.00%
  • Packaging:500MG
  • Price:$ 909.56
  • Delivery:In stock
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Relevant articles and documentsAll total 3 Articles be found

Stereoselective synthesis of L-[15N] amino acids with glucose dehydrogenase and galactose mutarotase as NADH regenerating system

Chiriac, Maria,Lupan, Iulia,Bucurenci,Popescu,Palibroda

, p. 171 - 174 (2008/09/19)

We have developed an efficient stereospecific enzymatic synthesis of L-[15N]-valine, L-[15N]-leucine, L-[15N]- norvaline, L-[15N]-norleucine and L-[15N]-isoleucine from the corresponding α-keto acids by coupling the reactions catalysed by leucine dehydrogenase and glucose dehydrogenase/galactose mutarotase. Giving high yields of L-amino acids, the procedure is economical and easy to perform and to monitor at a synthetically useful scale (1-10 g). Copyright

Chemo-Enzymatic Syntheses of Isotopically Labelled L-Amino Acids

Kelly, Nicholas M.,O'Neill, Bridget C.,Probert, John,Reid, Gordon,Stephen, Rosamund,et al.

, p. 6533 - 6536 (2007/10/02)

L-Alanine labelled with carbon-13 and nitrogen-15 has been prepared in good yield and high optical purity from achiral precursors using alanine dehydrogenase.This versatile approach may be simply adapted for the preparation of a range of isotopically labe

Process route upstream and downstream products

Process route

sodium 3-methyl-2-oxobutyrate
3715-29-5

sodium 3-methyl-2-oxobutyrate

(S)-<sup>(15)</sup>N-2-amino-3-methyl butanoic acid
59935-29-4,71261-62-6,96817-46-8

(S)-(15)N-2-amino-3-methyl butanoic acid

Conditions
Conditions Yield
With ammonium-15N hydrochloride; NAD; recombinant glucose dehydrogenase from Bacillus subtilis; recombinant galactomutarotase from Escherichia coli; In sodium hydroxide; at 30 ℃; pH=8.0 - 8.2;
90%
With formate dehydrogenase; 1,4-dihydronicotinamide adenine dinucleotide; 15N-ammonium formate; leucine dehydrogenase; diothiothreitol; Ambient temperature; TRIS, pH=6.5-7.0, 0.1M HCl;
84%
(2S,2S')-N-<2'-<15N>amino-3'-methylbutanoyl>bornane-10,2-sultam

(2S,2S')-N-<2'-<15N>amino-3'-methylbutanoyl>bornane-10,2-sultam

(S)-<sup>(15)</sup>N-2-amino-3-methyl butanoic acid
59935-29-4,71261-62-6,96817-46-8

(S)-(15)N-2-amino-3-methyl butanoic acid

Conditions
Conditions Yield
With hydrogenchloride; lithium hydroxide; water; Yield given. Multistep reaction; 1.) THF, 0 deg C, 2 h, 2.) THF, O deg C;
(S)-<sup>(15)</sup>N-2-amino-3-methyl butanoic acid
59935-29-4,71261-62-6,96817-46-8

(S)-(15)N-2-amino-3-methyl butanoic acid

<sup>(15)</sup>N-(S)-1-benzyl-3-(3-methyl-1-(3-methylureido)butan-2-yl)urea
1360138-56-2

(15)N-(S)-1-benzyl-3-(3-methyl-1-(3-methylureido)butan-2-yl)urea

Conditions
Conditions Yield
Multi-step reaction with 8 steps
1.1: sodium hydroxide / 0 °C
2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h
2.2: 0.33 h
3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 0 °C
4.1: hydrazine hydrate / methanol / 70 °C
5.1: dichloromethane / 0.25 h
6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.08 h / 0 °C
7.1: 0.5 h / 0 °C
8.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.17 h
8.2: 1 h
With di-isopropyl azodicarboxylate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
(S)-<sup>(15)</sup>N-2-amino-3-methyl butanoic acid
59935-29-4,71261-62-6,96817-46-8

(S)-(15)N-2-amino-3-methyl butanoic acid

di-<i>tert</i>-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(15N)-N<sup>α</sup>-t-Boc-L-valine
141509-91-3

(15N)-Nα-t-Boc-L-valine

Conditions
Conditions Yield
With sodium hydroxide; at 0 ℃;
98%
(S)-<sup>(15)</sup>N-2-amino-3-methyl butanoic acid
59935-29-4,71261-62-6,96817-46-8

(S)-(15)N-2-amino-3-methyl butanoic acid

<sup>(15)</sup>N-(S)-tert-butyl (3-methyl-1-(3-methylureido)butan-2-yl)carbamate
1360138-53-9

(15)N-(S)-tert-butyl (3-methyl-1-(3-methylureido)butan-2-yl)carbamate

Conditions
Conditions Yield
Multi-step reaction with 6 steps
1.1: sodium hydroxide / 0 °C
2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h
2.2: 0.33 h
3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 0 °C
4.1: hydrazine hydrate / methanol / 70 °C
5.1: dichloromethane / 0.25 h
6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.08 h / 0 °C
With di-isopropyl azodicarboxylate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
(S)-<sup>(15)</sup>N-2-amino-3-methyl butanoic acid
59935-29-4,71261-62-6,96817-46-8

(S)-(15)N-2-amino-3-methyl butanoic acid

C<sub>2</sub>HF<sub>3</sub>O<sub>2</sub>*C<sub>7</sub>H<sub>17</sub>N<sub>2</sub><sup>(15)</sup>NO

C2HF3O2*C7H17N2(15)NO

Conditions
Conditions Yield
Multi-step reaction with 7 steps
1.1: sodium hydroxide / 0 °C
2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h
2.2: 0.33 h
3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 0 °C
4.1: hydrazine hydrate / methanol / 70 °C
5.1: dichloromethane / 0.25 h
6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.08 h / 0 °C
7.1: 0.5 h / 0 °C
With di-isopropyl azodicarboxylate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

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  • Kono Chem Co.,Ltd
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  • Contact Tel:86-29-86107037-8015
  • Emails:info@konochemical.com
  • Main Products:86
  • Country:China (Mainland)
  • Antimex Chemical Limied
  • Business Type:Lab/Research institutions
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  • Emails:anthony@antimex.com
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