59936-29-7

Basic information

• Product Name: Boc-L-Proline-methyl ester
• Synonyms: BOC-L-PROLINE METHYL ESTER;BOC-PRO-OME;Boc-L-Pro-OMe;N-BOC-poline methyl ester;N-tert-Butoxycarbonyl-L-proline methyl ester;N-alpha-t-Butyloxycarbonyl-L-proline methyl ester;Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester;Boc-L-Proline-methyl
• CAS NO: 59936-29-7
• Molecular Formula: C₁₁H₁₉NO₄
• Molecular Weight: 229.27
• Product Categories: Pyrrole&Pyrrolidine&Pyrroline;Amino Acids;Heterocyclic Building Blocks
• Mol File: 59936-29-7.mol
• Article Data: 102

Chemical Properties

• Boiling Point: 135°C/16mmHg(lit.)
• Flash Point: 128.3 °C
• Appearance: /
• Density: 1.12 g/cm³
• Vapor Pressure: 0.00232mmHg at 25°C
• Refractive Index: 1.4510 to 1.4550
• Storage Temp.: 2-8°C
• PKA: -3.35±0.40(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: Boc-L-Proline-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-L-Proline-methyl ester(59936-29-7)
• EPA Substance Registry System: Boc-L-Proline-methyl ester(59936-29-7)

Safety Data

• Hazardous Substances Data: 59936-29-7(Hazardous Substances Data)

Usage

Uses

N-Boc-L-proline methyl ester is generally used as a intermediate in pharmaceutical and chemical research.

InChI:InChI=1/C11H19NO4/c1-11(2,3)16-10(14)12-7-5-6-8(12)9(13)15-4/h8H,5-7H2,1-4H3/t8-/m0/s1

Upstream product

• 2133-40-6 L-proline methyl ester monohydrochloride 
• 404586-94-3 1-(tert-butoxy)-2-(tert-butoxy)carbonyl-1,2-dihydroisoquinoline 
• 88815-87-6 tert-butyl (2S)-2-(methylcarbamoyl)pyrrolidine-1-carboxylate 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 108963-96-8 (S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 186581-53-3 diazomethane 
• 13061-96-6 dihydroxy-methyl-borane 
• 74108-10-4 C₆H₁₅N*C₁₀H₁₇NO₄ 
• 4525-33-1 dimethyl dicarbonate 
• 147-85-3 L-proline 

Downstream Products

• 5211-23-4 N-carbobenzyloxy-L-proline methyl ester 
• 59378-82-4 N-(tert-butoxycarbonyl)pyrrolidine-2-carboxaldehyde 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 69610-41-9 Boc-L-Pro-H 
• 108963-96-8 (S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one 
• 34381-71-0 (S)-2-hydroxymethyl-1-methylpyrrolidine 
• 147-85-3 L-proline 
• 112348-45-5 1-tert-butyl 2-methyl 2-(prop-2-en-1-yl)pyrrolidine-1,2-dicarboxylate 
• 188200-05-7 1-(tertbutyloxycarbonyl)-5-(hydroxy)pyrrolidine-2-carboxylic acid methyl ester 
• 477961-03-8 2-[hydroxy[bis(4-vinylphenyl)]methyl]pyrrolidine-1-carboxylic acid tert-butyl ester 
• 886449-74-7 7-benzyl-6-oxo-1,7-diazaspiro[4.5]decane-1-carboxylic acid tert-butyl ester 
• 886449-72-5 6-oxo-1,7-diaza-spiro[4.5]decane-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

METHODS OF TREATING PAINFUL DIABETIC PERIPHERAL NEUROPATHY

Provided herein are methods of treating painful diabetic peripheral neuropathy, such as advanced painful DPN, in a patient by administering to the patient an effective amount of NYX-2925 or a pharmaceutically acceptable salt thereof. Also provided are crystalline forms of 3-hydroxy-2-(5-isobutyryl-1-oxo-2,5-diazaspiro[3,4]octan-2-yl)butanamide.

Tetrahydropyrido [3, 4-d] pyrimidine derivative and medical application thereof

The invention relates to a compound as shown in a general formula (I) or a stereoisomer, a deuterated compound, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or eutectic crystal thereof, an intermediate and a preparation method thereof, and application of the compound in preparation of drugs for treating diseases related to KRas-G12C activity or expression quantity.

Direct Amidation of Esters by Ball Milling**

The direct mechanochemical amidation of esters by ball milling is described. The operationally simple procedure requires an ester, an amine, and substoichiometric KOtBu and was used to prepare a large and diverse library of 78 amide structures with modest to excellent efficiency. Heteroaromatic and heterocyclic components are specifically shown to be amenable to this mechanochemical protocol. This direct synthesis platform has been applied to the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals as well as the gram-scale synthesis of an active pharmaceutical, all in the absence of a reaction solvent.