6009-98-9 Usage
Description
Taurochenodeoxycholic acid (TCDCA) sodium salt is a taurine-conjugated form of the primary bile acid chenodeoxycholic acid (CDCA). It is a bile acid conjugate and metabolite with anti-inflammatory activity. TCDCA plays a role in lipid metabolism and liver function, and its serum levels can serve as a marker for disease progression in patients with liver cirrhosis.
Uses
Used in Pharmaceutical Industry:
Taurochenodeoxycholic acid sodium salt is used as an anti-inflammatory agent for its ability to inhibit hepatocyte apoptosis through suppression of Bid translocation to mitochondria.
Used in Research and Development:
Taurochenodeoxycholic acid sodium salt is used as an internal standard for the quantification of Taurochenodeoxycholic Acid by GCor LC-mass spectrometry, aiding in the development of new drugs and therapies.
Used in Diagnostic Applications:
Taurochenodeoxycholic acid sodium salt is used as a marker for disease progression in patients with liver cirrhosis, helping in the diagnosis and monitoring of liver health.
Check Digit Verification of cas no
The CAS Registry Mumber 6009-98-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,0 and 9 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6009-98:
(6*6)+(5*0)+(4*0)+(3*9)+(2*9)+(1*8)=89
89 % 10 = 9
So 6009-98-9 is a valid CAS Registry Number.
InChI:InChI=1/C26H45NO6S.Na/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29;/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-;/m1./s1
6009-98-9Relevant articles and documents
Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts
Venturoni, Francesco,Gioiello, Antimo,Sardella, Roccaldo,Natalini, Benedetto,Pellicciari, Roberto
experimental part, p. 4109 - 4115 (2012/06/15)
A multi-gram scale protocol for the N-acyl amidation of bile acids with glycine and taurine has been successfully developed under continuous flow processing conditions. Selecting ursodeoxycholic acid (UDCA) as the model compound and N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) as the condensing agent, a modular mesoreactor assisted flow set-up was employed to significantly speed up the optimization of the reaction conditions and the flow scale-up synthesis. The results in terms of yield, in line purification, analysis, and implemented flow set-up for the reaction optimization and large scale production are reported and discussed.