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601-87-6

601-87-6

Identification

  • Product Name:Benzenamine,3-methyl-2-nitro-

  • CAS Number: 601-87-6

  • EINECS:

  • Molecular Weight:152.153

  • Molecular Formula: C7H8N2O2

  • HS Code:2921430090

  • Mol File:601-87-6.mol

Synonyms:m-Toluidine,2-nitro- (6CI);2-Nitro-3-methylaniline;3-Amino-2-nitrotoluene;3-Methyl-2-nitroaniline;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:3-Methyl-2-nitroaniline 97%
  • Packaging:25 g
  • Price:$ 293
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:3-Methyl-2-nitroaniline 97%
  • Packaging:1 g
  • Price:$ 32
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:3-Methyl-2-nitroaniline 97%
  • Packaging:5 g
  • Price:$ 88
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:3-Methyl-2-nitroaniline 95+%
  • Packaging:5g
  • Price:$ 59
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:3-Methyl-2-nitroaniline 95+%
  • Packaging:1g
  • Price:$ 22
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:3-Methyl-2-nitroaniline 95+%
  • Packaging:25g
  • Price:$ 191
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:3-Methyl-2-nitroaniline 95+%
  • Packaging:10g
  • Price:$ 102
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:3-Methyl-2-nitroaniline 95+%
  • Packaging:25g
  • Price:$ 199
  • Delivery:In stock
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  • Manufacture/Brand:Chemcia Scientific
  • Product Description:3-Methyl-2-nitro-phenylamine 95%
  • Packaging:25 G
  • Price:$ 170
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:3-Amino-2-nitrotoluene
  • Packaging:1 g
  • Price:$ 60
  • Delivery:In stock
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Relevant articles and documentsAll total 13 Articles be found

Microwave-assisted reduction of aromatic nitro compounds with novel oxo-rhenium complexes

Blacque, Olivier,Grieco, Gabriele

, (2021/09/16)

The reduction of several aromatic nitro compounds to amines by means of the two novel catalytic systems ([IMes]2ReOBr3)/PhSiH3 and ([Py]3ReNOBr2)/PhSiH3 under microwave irradiation is here reported. These two systems were able to perform the reduction of nitro groups with higher TON and TOF when compared with previously reported systems based on oxo-rhenium core under standard heating, although they showed a lesser broad reaction scope compared with the known systems.

METALLOENZYME INHIBITOR COMPOUNDS

-

Page/Page column 45, (2020/07/25)

Provided are compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.

3-OXO-1,4-DIAZEPINYLE COMPOUNDS AS NRF2 ACTIVATORS

-

, (2018/07/05)

The present invention relates to bisaryl lactam compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the compounds of this invention include a compound of Formula (I):

3-(2,3-DIHYDRO-1H-INDEN-5-YL)PROPANOIC ACID DERIVATIVES AND THEIR USE AS NRF2 REGULATORS

-

Page/Page column 60-61, (2018/06/30)

The present invention relates to compounds of Formula (I), and Formula (II), wherein B is benzotriazolyl, phenyl, triazolopyridinyl, or -(CH2)2-triazolyl each of which may be unsubstituted or substituted by 1, 2, or 3 substituents independently chosen from -C1-3 alkyl, -O-C1-3 alkyl, CN, - (CH2)2-O-(CH2)2-OR4 and halo; and D is -C(O)OH, -C(O)NHSO2CH3, -SO2NHC(O)CH3, 5-(trifluoromethyl)-4H-1,2,4-triazol-2-yl, or tetrazolyl; and their use as NRF2 regulators.

NRF2 REGULATORS

-

, (2017/01/02)

The present invention relates to aryl analogs Formula (I), pharmaceutical compositions containing them and their use as Nrf2 regulators.

Process route upstream and downstream products

Process route

sulfuric acid
7664-93-9

sulfuric acid

1-amino-3-methylbenzene
108-44-1

1-amino-3-methylbenzene

4-nitro-3-methylaniline
611-05-2

4-nitro-3-methylaniline

3-methyl-2-nitroaniline
601-87-6

3-methyl-2-nitroaniline

5-methyl-2-nitroaniline
578-46-1

5-methyl-2-nitroaniline

Conditions
Conditions Yield
Nitrieren;
1-fluoro-3-methyl-2-nitro-benzene
3013-27-2

1-fluoro-3-methyl-2-nitro-benzene

3-methyl-2-nitroaniline
601-87-6

3-methyl-2-nitroaniline

Conditions
Conditions Yield
With ammonium hydroxide; In ethanol; water; at 0 - 80 ℃; for 24h; Sealed tube;
3-methyl-2-nitrobenzoic acid
5437-38-7

3-methyl-2-nitrobenzoic acid

3-methyl-2-nitroaniline
601-87-6

3-methyl-2-nitroaniline

Conditions
Conditions Yield
With sodium azide; sulfuric acid;
Multi-step reaction with 3 steps
3: Br2, KOH
With potassium hydroxide; bromine;
Multi-step reaction with 3 steps
1: PCl5
2: HCO2NH4
3: Br2, aq. KOH
With potassium hydroxide; phosphorus pentachloride; bromine; ammonium formate;
In sulfuric acid;
Multi-step reaction with 2 steps
1.1: oxalyl dichloride / dichloromethane / 1 h / 20 - 25 °C
1.2: 0.5 h / 20 °C
2.1: bromine; sodium hydroxide / water / 2 h / 0 - 80 °C
With oxalyl dichloride; bromine; sodium hydroxide; In dichloromethane; water;
Multi-step reaction with 2 steps
1.1: oxalyl dichloride / dichloromethane / 1 h / 20 - 25 °C
1.2: 0.5 h / 20 °C
2.1: bromine; sodium hydroxide / water / 2 h / 0 - 80 °C
With oxalyl dichloride; bromine; sodium hydroxide; In dichloromethane; water;
Multi-step reaction with 2 steps
1: oxalyl dichloride / dichloromethane / 1 h / 20 - 25 °C
2: sodium hydroxide; bromine / 2 h / 0 - 80 °C
With oxalyl dichloride; bromine; sodium hydroxide; In dichloromethane;
Multi-step reaction with 2 steps
1.1: oxalyl dichloride / dichloromethane / 1 h / 20 - 25 °C / 760.05 Torr
1.2: 0.5 h / 20 °C
2.1: water; sodium hydroxide; bromine / 2 h / 0 - 80 °C
With oxalyl dichloride; water; bromine; sodium hydroxide; In dichloromethane;
4-methyl-benzofuroxan
27808-46-4

4-methyl-benzofuroxan

3-methyl-2-nitroaniline
601-87-6

3-methyl-2-nitroaniline

Conditions
Conditions Yield
With iron(II) sulfate; In water; dimethyl sulfoxide; for 48h; Ambient temperature;
90%
With HbO2(2+); In phosphate buffer; dimethyl sulfoxide; for 1h; pH=7.4;
100 % Chromat.
1-methyl-2,3-dinitrobenzene
602-01-7

1-methyl-2,3-dinitrobenzene

2-Methyl-6-nitroaniline
570-24-1

2-Methyl-6-nitroaniline

3-methyl-2-nitroaniline
601-87-6

3-methyl-2-nitroaniline

Conditions
Conditions Yield
With phenylsilane; C42H48Br3N4ORe; In toluene; at 220 ℃; for 1.5h; Overall yield = 43 percentSpectr.; Sealed tube; Microwave irradiation;
1-methyl-2,3-dinitrobenzene
602-01-7

1-methyl-2,3-dinitrobenzene

3-methyl-2-nitroaniline
601-87-6

3-methyl-2-nitroaniline

Conditions
Conditions Yield
With hydrogenchloride; ethanol; tin(ll) chloride; at 7 ℃;
With tin(ll) chloride;
3-chloro-2-nitrotoluene
5367-26-0

3-chloro-2-nitrotoluene

3-methyl-2-nitroaniline
601-87-6

3-methyl-2-nitroaniline

Conditions
Conditions Yield
With ammonia; at 200 ℃; im Rohr;
3-methyl-2-nitrobenzoyl chloride
50424-93-6

3-methyl-2-nitrobenzoyl chloride

3-methyl-2-nitroaniline
601-87-6

3-methyl-2-nitroaniline

Conditions
Conditions Yield
Multi-step reaction with 2 steps
2: Br2, KOH
With potassium hydroxide; bromine;
Multi-step reaction with 2 steps
1: benzene
2: aqueous potassium hypobromite
With potassium hypobromite; benzene;
Multi-step reaction with 2 steps
1: HCO2NH4
2: Br2, aq. KOH
With potassium hydroxide; bromine; ammonium formate;
m-Toluic acid
99-04-7

m-Toluic acid

3-methyl-2-nitroaniline
601-87-6

3-methyl-2-nitroaniline

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: HNO3
2: PCl5
3: HCO2NH4
4: Br2, aq. KOH
With potassium hydroxide; phosphorus pentachloride; bromine; nitric acid; ammonium formate;
4-acetylamino-2-nitrotoluene
2719-14-4

4-acetylamino-2-nitrotoluene

3-methyl-2-nitroaniline
601-87-6

3-methyl-2-nitroaniline

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: (i) HNO3, (ii) H2SO4, EtOH
2: (deamination)
3: SnCl2
With tin(ll) chloride;

Global suppliers and manufacturers

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  • Amadis Chemical Co., Ltd.
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  • Shaanxi BLOOM TECH Co.,Ltd
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  • Win-Win chemical Co.Ltd
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  • GIHI CHEMICALS CO.,LIMITED
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  • Finetech Industry Limited
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  • Antimex Chemical Limied
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