6045-93-8

Basic information

• Product Name: 1-(morpholin-4-yl)-4-phenylbutane-1,4-dione
• CAS NO: 6045-93-8
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247.2897
• Mol File: 6045-93-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 452.2°C at 760 mmHg
• Flash Point: 227.3°C
• Density: 1.165g/cm³
• Vapor Pressure: 2.29E-08mmHg at 25°C
• Refractive Index: 1.544
• CAS DataBase Reference: 1-(morpholin-4-yl)-4-phenylbutane-1,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(morpholin-4-yl)-4-phenylbutane-1,4-dione(6045-93-8)
• EPA Substance Registry System: 1-(morpholin-4-yl)-4-phenylbutane-1,4-dione(6045-93-8)

Safety Data

• Hazardous Substances Data: 6045-93-8(Hazardous Substances Data)

Upstream product

• 71-43-2 benzene 
• 101-41-7 benzeneacetic acid methyl ester 
• 103-82-2 phenylacetic acid 
• 122-78-1 phenylacetaldehyde 
• 2243-53-0 styrylacetic acid 
• 5117-12-4 N-Acryloylmorpholine 
• 98-88-4 benzoyl chloride 
• 611-73-4 Benzoylformic acid 
• 2051-95-8 succinylbenzene 
• 110-91-8 morpholine 
• 101012-63-9 2-bromo-4-phenyl-4-butanolide 

Downstream Products

• 81233-51-4 ((1S,2S)-2-Hydroxy-2-phenyl-cyclopropyl)-morpholin-4-yl-methanone 
• 81233-51-4 ((1R,2S)-2-Hydroxy-2-phenyl-cyclopropyl)-morpholin-4-yl-methanone 
• 61123-44-2 1-morpholino-4-phenylbutan-1-one 
• 101115-22-4 4-hydroxy-1-morpholino-4-phenylbutan-1-one 

Relevant articles and documents

Iridium-Catalyzed Asymmetric Hydrogenation of ?- A nd ?-Ketoacids for Enantioselective Synthesis of ?- A nd ?-Lactones

A highly efficient asymmetric hydrogenation of ?- A nd ?-ketoacids was developed by using a chiral spiro iridium catalyst (S)-1a, affording the optically active ?- A nd ?-hydroxy acids/lactones in high yields with excellent enantioselectivities (up to >99% ee) and turnover numbers (TON up to 100000). This protocol provides an efficient and practical method for enantioselective synthesis of Ezetimibe.

Visible-Light-Promoted Synthesis of 1,4-Dicarbonyl Compounds via Conjugate Addition of Aroyl Chlorides

A facile visible-light photocatalytic conjugate addition to prepare 1,4-dicarbonyl compounds has been developed by employing readily available aroyl chlorides as aryl radical sources. This operationally simple method shows a broad scope with regard to both aroyl chlorides and Michael acceptors. As a result, a variety of 1,4-diketones were efficiently synthesized in moderate to good yields.

Enantioselective Ruthenium(II)/Xyl-SunPhos/Daipen-Catalyzed hydrogenation of γ-Ketoamides

A0series of γ-hydroxy amides were synthesized with high ena~tioselectivities (up to 99%) usyng asymmetric hydrogenation of the corresponding γ-ketoamides in the presence of Ru-Xyl-SunPhos-Daipen catalyst providing key building blocks for a variety of natu