60577-30-2

Basic information

• Product Name: 4-IODO-2-METHYLPHENOL
• Synonyms: 4-IODO-O-CRESOL;4-IODO-2-METHYLPHENOL;NISTC60577302;Phenol, 4-iodo-2-Methyl-;4-Iodo-2-Methylphenol 97%
• CAS NO: 60577-30-2
• Molecular Formula: C₇H₇IO
• Molecular Weight: 234.03
• EINECS: 200-258-5
• Product Categories: Aromatic Halides (substituted)
• Mol File: 60577-30-2.mol
• Article Data: 18

Chemical Properties

• Melting Point: 67-68 °C(lit.)
• Boiling Point: 105-110 °C2 mm Hg(lit.)
• Flash Point: 116.4 °C
• Appearance: /
• Density: 1.7904 (estimate)
• Vapor Pressure: 0.00452mmHg at 25°C
• Refractive Index: 1.646
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 9.70±0.18(Predicted)
• CAS DataBase Reference: 4-IODO-2-METHYLPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODO-2-METHYLPHENOL(60577-30-2)
• EPA Substance Registry System: 4-IODO-2-METHYLPHENOL(60577-30-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 60577-30-2(Hazardous Substances Data)

Usage

Uses

4-Iodo-2-methylphenol was used as starting reagent in the synthesis of an agonist for the peroxisome proliferator-activated receptor δ (PPARδ) GW501516, a potential antiobesity drug.

General Description

4-Iodo-2-methylphenol was prepared by direct iodination of 2-methylphenol in aqueous alcohol solvents by the action of a reagent prepared in situ from sodium hypochlorite and sodium iodide.

InChI:InChI=1/C7H7IO/c1-5-4-6(8)2-3-7(5)9/h2-4,9H,1H3

Upstream product

• 2835-96-3 4-amino-2-methylphenol 
• 95-48-7 ortho-cresol 
• 197243-41-7 o-cresol; thallium(I)-(2-methyl-phenolate) 
• 16419-60-6 2-Methylphenylboronic acid 
• 4186-52-1 2,4-diiodo-6-methyl-phenol 
• 7080-50-4 chloramine-T hydrate 
• 799766-25-9 1-(2,2-dimethoxy-ethoxy)-4-iodo-2-methyl benzene 
• 533-18-6 2-methylphenyl acetate 
• 859820-99-8 2,2'-dimethyl-4,4'-selanediyl-di-phenol 
• 855354-81-3 acetic acid-(4-iodo-2-methyl-phenyl ester) 

Downstream Products

• 75581-11-2 1-iodo-4-methoxy-3-methylbenzene 
• 145294-62-8 (R)-(+)-1-chloro-3-(4-iodo-2-methylphenoxy)-3-phenylpropane 
• 146304-03-2 (S)-(-)-1-chloro-3-(4-iodo-2-methylphenoxy)-3-phenylpropane 
• 210367-97-8 4-Dodecyloxy-1-iodo-3-methylbenzene 
• 15174-69-3 4-hydroxy-3-methyl-benzaldehyde 
• 95-48-7 ortho-cresol 
• 636589-63-4 4-{{2-[4-(trifluoromethyl)phenyl]-4-methylthiazol-5-yl}methylthio}-2-methylphenol 
• 239104-44-0 2-(4-iodo-2-methyl-phenoxy)-tetrahydro-pyran 
• 922529-57-5 4-[1-(tert-butoxycarbonyl)-(2S)-pyrrolidinylmethoxy]-1-iodo-3-methylbenzene 
• 350035-94-8 2-(4-ethynyl-2-methylphenoxy)perhydro-2H-pyrane 
• 377079-58-8 2-methyl-4-[3-methyl-4-(tetrahydro-pyran-2-yloxy)-phenyl]-but-3-yn-2-ol 
• 377079-60-2 4-(4-hexyl-phenylethynyl)-2-methyl-phenol 

Relevant articles and documents

A iodo phenol preparation method

The invention relates to a preparation method of iodo phenol, specific steps are as follows: (1) will be benzenes boric acid, potassium iodide is added in the methanol solution mixing, slowly adding the oxidizing agent, to get the crude product after the reaction; (2) the step (1) of the crude product by washing, after separation and purification, to obtain the iodo phenol. Compared with the prior art, the preparation method of this invention has a region of high selectivity, the substrate can be expanded is good, the preparation process is simple, convenient operation and the like.

Gas-Chromatographic identifi cation of products formed in iodination of methyl phenols by retention indices

Iodination reaction followed by conversion of iodine-substituted methylphenols to the corresponding trifl uoroacetates was suggested for improving the sensitivity of the gas-chromatographic determination of phenol and its methyl-substituted derivatives (al isomers of mono- and diethylphenols, 2,3,5-, 2,3,6-, and 3,4,5-trimethylphenols) in aqueous media. Acylation products of iodo methylphenols (104 compounds) were identifi ed by linear-logarithmic retention indices on a standard nonpolar polydimethylsiloxane stationary phase, and the pattern of their variation with the number and nature of substituents were characterized. A procedure for identifi cation of methyl-substituted phenols in water in their gas-chromatographic determination with an electron-capture detector was developed. Pleiades Publishing, Ltd., 2012.

Iodination of anilines and phenols with 18-crown-6 supported ICl 2-

A highly crystalline iodinating reagent, {[K·18-C-6]ICl 2}n, was synthesized in high yield (93%). The trihalide is supported by an 18-crown-6 macrocycle and forms a coordination polymer in the solid state. This reagent iodinates anilines and phenols efficiently under mild conditions. Controlled mono-iodination with anilines was easily achieved while poly-iodination was observed with phenols.