6065-82-3Relevant articles and documents
One-pot production of diethyl maleate via catalytic conversion of raw lignocellulosic biomass
Cai, Zhenping,Chen, Rujia,Zhang, Hao,Li, Fukun,Long, Jinxing,Jiang, Lilong,Li, Xuehui
supporting information, p. 10116 - 10122 (2021/12/24)
The conversion of lignocellulose into a value-added chemical with high selectivity is of great significance but is a big challenge due to the structural diversities of biomass components. Here, we have reported an efficient approach for the one-step conversion of raw lignocellulose into diethyl maleate by the polyoxometalate ionic liquid [BSmim]CuPW12O40 in ethanol under mild conditions. The results reveal that all of the fractions in biomass, i.e., cellulose, lignin and hemicellulose, were simultaneously converted into diethyl maleate (DEM), achieving a 329.6 mg g-1 yield and 70.3% selectivity from corn stalk. Importantly, the performance of the ionic liquid catalyst [BSmim]CuPW12O40 was nearly twice that of CuHPW12O40, which can be attributed to the lower incorporation of the Cu2+ site in [BSmim]CuPW12O40. Hence, this process opens a promising route for producing bio-based bulk chemicals from raw lignocellulose without any pretreatment.
Synthesis method of 2-formyl-4-carboxylic acid ethyl thiazole
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Paragraph 0017-0018; 0024; 0029-0030; 0035-0036; 0041-0042, (2019/11/18)
The invention discloses a synthesis method of 2-formyl-4-carboxylic acid ethyl ester thiazole, the synthesis method takes dichloroacetic acid, sodium ethoxide and ethanol as initial raw materials to firstly synthesize 2,2-diethoxyacetic acid ethyl ester, then ammonia water is added to ammoniate to obtain 2,2-diethoxyacetamide, the 2,2-diethoxyacetamide is converted into 2,2-diethoxythioacetamide through thioation by use of a vulcanizing reagent, then the 2,2-diethoxythioacetamide is condensed with 3-ethyl bromopyruvate to generate 2-diethoxymethyl-4-carboxylic acid ethyl ester thiazole, and finally acid deprotection is performed in an acetone solution to obtain the 2-formyl-4-carboxylic acid ethyl ester thiazole. According to the synthesis method of the 2-formyl-4-carboxylic acid ethyl ester thiazole, and the used raw materials are low in price, high in safety and easy to obtain. In addition, the synthesis method has the advantages of short synthesis route, high yield, high chemical purity of the obtained product, no need of complicated operation, and large-scale production.
METHOD FOR THE PRODUCTION OF ACETAMIDE ACETALS
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Example 1, (2010/02/14)
The invention relates to a method for production of acetamide acetals of formula (I), where R1 and R2 independently = C1-C6 alkyl, phenyl or benzyl, or together form a C2-C6 alkylene and R3 and R4 independently = H, C1-C6 alkyl or benzyl, or together form a C3-C6 alkylene, whereby a glyoxylate ester diacetal of formula (II), in which R1 and R2 are as above and R5 = C1-C4 alkyl, is reacted with DMF or an amine of formula (III) NHR4R5, where R4 and R5 are as above, in the presence of 0.005 to 3 Mol %, based on the amine of formula (III), of an alcoholate of formula (IV) XOC1-C4, where X = Na, K or Li, at a reaction temperature of 0 to 100 °C to give the corresponding compound of formula (I).