607-72-7

Basic information

• Product Name: 2-Methyl-5-hydroxyquinoline
• Synonyms: 2-Methyl-5-hydroxyquinoline
• CAS NO: 607-72-7
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18456
• Mol File: 607-72-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Methyl-5-hydroxyquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-5-hydroxyquinoline(607-72-7)
• EPA Substance Registry System: 2-Methyl-5-hydroxyquinoline(607-72-7)

Safety Data

• Hazardous Substances Data: 607-72-7(Hazardous Substances Data)

Usage

General Description

2-Methyl-5-hydroxyquinoline, also known as 5-hydroxy-2-methylquinoline, is a chemical compound with the molecular formula C10H9NO. It is a derivative of quinoline and contains a hydroxyl group at the 5th position and a methyl group at the 2nd position of the quinoline ring. 2-Methyl-5-hydroxyquinoline is used as a building block in the synthesis of pharmaceuticals and agrochemicals, and also has applications as a corrosion inhibitor and fluorescent dye. Additionally, 2-Methyl-5-hydroxyquinoline has been studied for its potential antioxidant and anti-inflammatory properties. This chemical has the potential for various industrial and medicinal applications due to its unique structure and properties.

Upstream product

• 1780-19-4 1,2,3,4-tetrahydro-2-methylquinoline 
• 91-63-4 2-methylquinoline 
• 27463-92-9 5,6,7,8-Tetrahydro-2-methylquinolin-5-one 
• 123-73-9 crotonaldehyde 
• 367521-07-1 2,4-dibromo-5-hydroxyaniline 
• 844903-57-7 5-hydroxy-2-methylquinolinium bromide 
• 23877-94-3 2-methyl-5-nitroquinoline 
• 123-73-9 trans-Crotonaldehyde 
• 54408-50-3 2-methyl-5-aminoquinoline 

Downstream Products

• 108825-11-2 2-methyl-1,2,3,4-tetrahydro-5-quinolinol 
• 149312-98-1 5-hydroxyquinoline-2-carboxylic acid 
• 583031-15-6 2-methyl-5-(2-piperazin-1-ylethoxy)quinoline 

Relevant articles and documents

Multi-Functional Oxidase Activity of CYP102A1 (P450BM3) in the Oxidation of Quinolines and Tetrahydroquinolines

Tetrahydroquinoline, quinoline, and dihydroquinolinone are common core motifs in drug molecules. Screening of a 48-variant library of the cytochrome P450 enzyme CYP102A1 (P450BM3), followed by targeted mutagenesis based on mutation-selectivity correlations from initial hits, has enabled the hydroxylation of substituted tetrahydroquinolines, quinolines, and 3,4-dihydro-2-quinolinones at most positions around the two rings in good to high yields at synthetically relevant scales (1.5 g L?1 day?1). Other oxidase activities, such as C?C bond desaturation, aromatization, and C?C bond formation, were also observed. The enzyme variants, with mutations at the key active site residues S72, A82, F87, I263, E267, A328, and A330, provide direct and sustainable routes to oxy-functionalized derivatives of these building block molecules for synthesis and drug discovery.

SUBSTITUTED TETRAHYDRO-QUINOLINE-SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS

The present invention refers to substituted tetrahydro-quinoline-sulfonamide compounds of general formula (I): a method for their preparation, a medicament comprising these compounds and the use of substituted tetrahydro-quinoline-sulfonamide compounds for the preparation of medicaments for 5-HT6 receptor regulation as well as for the treatment of disorders related thereto.

QUINOLINE AND QUINAZOLINE DERIVATIVES HAVING AFFINITY FOR 5HT1-TYPE RECEPTORS

Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression or anxiety, are also disclosed.