608-25-3

Basic information

• Product Name: 2-Methylresorcinol
• Synonyms: 2-Methylresorcinol,1,3-Dihydroxy-2-methylbenzene;2,6-Dihydroxytoluene, 2-Methyresorcinol;2-Methylresorcinol technical grade, 90%;2,6-Dihydroxytoluene for synthesis;1,3-Dihydroxy-2-methylbenzene;2,6-Dihydroxy-1-methylbenzene;2-methyl-1,3-dihydroxybenzene;2-methyl-3-benzenediol
• CAS NO: 608-25-3
• Molecular Formula: C₇H₈O₂
• Molecular Weight: 124.14
• EINECS: 210-155-8
• Product Categories: Building Blocks;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Polyols;fine chemicals;Intermediates of Dyes and Pigments;Aromatic Hydrocarbons (substituted) & Derivatives;Benzene derivates;Organic Chemicals;Dye Intermediate
• Mol File: 608-25-3.mol
• Article Data: 21

Chemical Properties

• Melting Point: 114-120 °C(lit.)
• Boiling Point: 264 °C(lit.)
• Flash Point: 135°C
• Appearance: White/Glassy Irregular Shaped Granules
• Density: 1.1006 (rough estimate)
• Vapor Pressure: 0.00201mmHg at 25°C
• Refractive Index: 1.4922 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: 263g/l
• PKA: pK1:10.05;pK2:11.64 (25°C,μ=0.65)
• Water Solubility: Soluble in water and methanol.
• BRN: 2042177
• CAS DataBase Reference: 2-Methylresorcinol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylresorcinol(608-25-3)
• EPA Substance Registry System: 2-Methylresorcinol(608-25-3)

Safety Data

• Hazard Codes: T,C
• Statements: 25-36/37/38-34-20/21/22
• Safety Statements: 26-36-45-37/39-28A-36/37/39-27
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: VH2009500
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 608-25-3(Hazardous Substances Data)

Usage

Uses

2-Methylresorcinol is used in the preparation of aromatic benziporphyrins, tripyrrane analogs and C-5-bromo-2-hydroxyphenylcalix[4]-2-methylresorcinarene. Further, it is employed in oxidative and non-oxidative hair dye formulations.

Application

2-Methylresorcinol is used as medicine, pesticide, dye intermediate, hair auxiliaries, etc.

Preparation

Synthesis of 2-methylresorcinol: The synthetic routes to an alkylresorcinol that is partially alkylated at a position other than the 4th position on the aromatic ring are multistep and give low overall yields. For example, a 50% yield of a 2-methylresorcinol is obtained by hydrogenation of resorcinol and methylation of the resulting dihydroresorcinol to 2-methylcyclohexane-1,3-dione which on treatment with bromine is converted into 4,6-dibromo-2-methylresorcinol and finally hydrogenolysis of the dibromo derivative to produce the 2-methylresorcinol. Another example is that 5-methylresorcinol can be prepared by a five-step synthesis starting with p-toluidine or a four-step synthesis starting from ethyl crotonate. The five-step synthesis involves acetylation, two-step nitration, reductive hydrogenation, and hydrolysis.Literature source US04086281

General Description

The reaction between 2-methylresorcinol and 2-alkenals was studied to investigate the scavenging ability of m-diphenols for the 2-alkenals formed during lipid oxidation.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C7H8O2/c1-5-6(8)3-2-4-7(5)9/h2-4,8-9H,1H3

Synthetic route

3,5-diamino-4-methylbenzoic acid (6633-36-9) → 2-methylbenzene-1,3-diol (608-25-3)

Conditions	Yield
Stage #1: 3,5-diamino-4-methylbenzoic acid With sulfuric acid; zinc(II) chloride; sodium nitrite In water at 2℃; for 5h; Stage #2: With sulfuric acid; sodium hydroxide In water for 1.75h; Reflux;	98.9%

2-methylcyclohexane-1,3-dione (1193-55-1) → 2-methylbenzene-1,3-diol (608-25-3)

Conditions	Yield
With 5 mol% Pd/C; hydrogen; potassium carbonate In N,N-dimethyl acetamide at 150℃; under 532.036 Torr; for 20h;	92%
palladium-carbon In 1,3,5-trimethyl-benzene	71%
	69.9%

methanol (67-56-1) + recorcinol (108-46-3) → 2-methylbenzene-1,3-diol (608-25-3)

Conditions	Yield
With SO42-/ZrO2-TiO2 at 350℃; Reagent/catalyst;	66.1%

2,6-dimethoxytoluene (5673-07-4) → 2-methylbenzene-1,3-diol (608-25-3)

Conditions	Yield
With pyridinium hydrobromide perbromide In xylene for 2h; Heating;	65%

2-methylcyclohexane-1,3-dione (1193-55-1) → 2-methylbenzene-1,3-diol (608-25-3) + 3-hydroxy-2-methyl-1-cyclohexanone (102547-88-6)

Conditions	Yield
With bis(η5-cyclopentadienyl)hafnium dihydride In isopropyl alcohol at 80℃; for 8h;	A 39% B 52%

ortho-cresol (95-48-7) → 4-methyl resorcinol (496-73-1) + 2-methylbenzene-1,4-diol (95-71-6) + 2-methylbenzene-1,3-diol (608-25-3) + 3-methylbenzene-1,2-diol (488-17-5)

Conditions	Yield
With hydrogen fluoride; dihydrogen peroxide; antimony pentafluoride at -40℃; for 0.5h; Product distribution;	A 3% B 17% C 3% D 4%
With hydrogen fluoride; dihydrogen peroxide; antimony pentafluoride at -40℃; for 0.5h;	A 3% B 17% C 3% D 4%

3-methoxy-2-methylphenol (6971-52-4) → 2-methylbenzene-1,3-diol (608-25-3)

Conditions	Yield
With hydrogen iodide

2,6-dihydroxybenzaldehyde (387-46-2) → 2-methylbenzene-1,3-diol (608-25-3)

Conditions	Yield
With hydrogenchloride; amalgamated zinc at 100℃;

2,4-dihydroxy-3-methylbenzoic acid (4707-49-7) → 2-methylbenzene-1,3-diol (608-25-3)

Conditions	Yield
at 220℃;

methyl 2,4-dihydroxy-3-methylbenzoate (33662-58-7) → 2-methylbenzene-1,3-diol (608-25-3)

Conditions	Yield
With potassium hydroxide unter Wasserstoff;

2-hydroxy-4-methoxy-3-methylbenzoic acid (116371-82-5) → 2-methylbenzene-1,3-diol (608-25-3)

Conditions	Yield
With hydrogen iodide

6-acetoxy-6-methylcyclohexa-2,4-dienone (7577-74-4) + acetic acid (64-19-7) → 4-methyl resorcinol (496-73-1) + 2-methylbenzene-1,3-diol (608-25-3) + 3-methylbenzene-1,2-diol (488-17-5)

Conditions	Yield
at 110℃; beim anschliessenden Erwaermen mit wss.-methanol. HCl;

2-Chlor-2-methyl-cyclohexandion-(1,3) (52956-17-9) → 2-methylbenzene-1,3-diol (608-25-3)

Conditions	Yield
(i) HCl, DMF, (ii) aq. HCl; Multistep reaction;

6-acetoxy-6-methylcyclohexa-2,4-dienone (7577-74-4) → 2-methylbenzene-1,3-diol (608-25-3)

Conditions	Yield
(i) Ac2O, H2SO4, (ii) Py, (iii) aq. NaOH, MeOH; Multistep reaction;

2-oxy-6-amino-toluene → 2-methylbenzene-1,3-diol (608-25-3)

Conditions	Yield
With sulfuric acid Diazotization;

2-hydroxy-4-methoxy-3-methylbenzoic acid (116371-82-5) + hydrogen iodide (10034-85-2) → 2-methylbenzene-1,3-diol (608-25-3)

4-hydroxysalicylic acid (89-86-1) → 2-methylbenzene-1,3-diol (608-25-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium; methanol / dann die Mischung mit Methyljodid versetzen 2: hydriodic acid View Scheme

methyl 2,4-dihydroxybenzoate (2150-47-2) → 2-methylbenzene-1,3-diol (608-25-3)

Conditions	Yield
Multi-step reaction with 4 steps 1: aluminium chloride; diethyl ether / Einleiten von Chlorwasserstoff und anschliessendes Erwaermen mit Wasser 2: aq. NaOH solution 3: 100 - 110 °C 4: amalgamated zinc; aqueous HCl / 100 °C View Scheme

5-carbomethoxy-6-hydroxysalicylaldehyde (39503-26-9) → 2-methylbenzene-1,3-diol (608-25-3)

Conditions	Yield
Multi-step reaction with 3 steps 1: aq. NaOH solution 2: 100 - 110 °C 3: amalgamated zinc; aqueous HCl / 100 °C View Scheme

3-formyl-2, 4-dihydroxybenzoic acid (4435-88-5) → 2-methylbenzene-1,3-diol (608-25-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: 100 - 110 °C 2: amalgamated zinc; aqueous HCl / 100 °C View Scheme

MCPA (94-74-6) → 4,6-dichloro-2-methylphenol (1570-65-6) + 2-methyl-4-chlorophenol (1570-64-5) + 2-methylbenzene-1,4-diol (95-71-6) + 2-methylbenzene-1,3-diol (608-25-3) + 2,5-dihydroxy-3-methylbenzoaldehyde (108372-60-7) + 2-Methyl-1,4-benzoquinone (553-97-9) + ortho-cresol (95-48-7) + 3-methylbenzene-1,2-diol (488-17-5) + 2-chloro-6-methylphenol (87-64-9) + 5-chloro-7-methyl-3H-benzofuran-2-one

Conditions	Yield
With water UV-irradiation;

...Expand

3-chloro-o-cresol (3260-87-5) → 2-methylbenzene-1,3-diol (608-25-3)

Conditions	Yield
Stage #1: 3-chloro-o-cresol With sodium formate; copper(l) chloride; sodium hydroxide; sodium sulfite In water at 195 - 200℃; under 7500.75 - 9000.9 Torr; Autoclave; Large scale; Stage #2: With hydrogenchloride In water Large scale;
Stage #1: 3-chloro-o-cresol With sodium formate; copper(l) chloride; sodium hydroxide at 195 - 200℃; for 1.5h; Autoclave; Stage #2: With hydrogenchloride In water at 30℃; pH=2 - 3;

p-Toluic acid (99-94-5) → 2-methylbenzene-1,3-diol (608-25-3)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: acetic acid; nitric acid / methanol / 3 h / 10 - 60 °C 2.1: iron(III) chloride; manganese(IV) oxide; hydrazine hydrate / diethyl ether / 4 h / 80 °C / Reflux 3.1: sulfuric acid; zinc(II) chloride; sodium nitrite / water / 5 h / 2 °C 3.2: 1.75 h / Reflux View Scheme

2-methylbenzene-1,3-diol (608-25-3) + dicyanozinc (557-21-1) → 2,4-dihydroxy-3-methylbenzaldehyde (6248-20-0)

Conditions	Yield
With hydrogenchloride In diethyl ether at 20℃;	100%
With hydrogenchloride; water 1.) ether, 45 min, 2.) 40 deg C; Yield given. Multistep reaction;
With hydrogenchloride
With hydrogenchloride In diethyl ether at 20℃; Gattermann formylation;

2-methylbenzene-1,3-diol (608-25-3) + methyl iodide (74-88-4) → 2,6-dimethoxytoluene (5673-07-4)

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide	100%

4-hydroxyphenylacetate (156-38-7) + 2-methylbenzene-1,3-diol (608-25-3) → 2,4,4'-trihydroxy-3-methyldeoxybenzoin (139256-03-4)

Conditions	Yield
With boron trifluoride diethyl etherate at 110℃; for 0.5h; Heating / reflux;	99%
With boron trifluoride diethyl etherate at 60 - 70℃; for 5h;	97%
With boron trifluoride diethyl etherate at 110℃; for 2h; Inert atmosphere;

2-methylbenzene-1,3-diol (608-25-3) → 4,6-dibromo-2-methylbenzene-1,3-diol (63992-60-9)

Conditions	Yield
With benzyltrimethylammonium tribromide In methanol; dichloromethane	99%
With benzyltrimethylammonium tribromide In methanol; dichloromethane for 1h; Ambient temperature;	93%
With benzyltrimethylammonium tribromide	70%
With bromine In acetic acid
With bromine In dichloromethane for 2h;	5.54 g

2-methylbenzene-1,3-diol (608-25-3) + acetic anhydride (108-24-7) → 1-(2,4-dihydroxy-3-methylphenyl)ethanone (10139-84-1)

Conditions	Yield
With boron trifluoride diethyl etherate at 80℃; for 6h;	99%
Stage #1: 2-methylbenzene-1,3-diol With boron trifluoride diethyl etherate at 70℃; Friedel-Crafts Acylation; Stage #2: acetic anhydride at 20 - 80℃; for 7h;	95%
Stage #1: 2-methylbenzene-1,3-diol With boron trifluoride diethyl etherate at 70℃; Stage #2: acetic anhydride at 80℃; for 6h;	85%

2-methylbenzene-1,3-diol (608-25-3) + ethyl 2-oxocyclohexane carboxylate (1655-07-8) → 3-Hydroxy-4-methyl-7,8,9,10-tetrahydro-6H-dibenzopyran-6-one (55047-37-5)

Conditions	Yield
With sulfuric acid at 0℃; for 2.5h;	99%
With sulfuric acid In ethanol at 0 - 20℃; Pechmann condensation;	84%
With sulfuric acid In water at 20℃; for 15h; Pechmann condensation;	71%

2-methylbenzene-1,3-diol (608-25-3) + benzyl chloride (100-44-7) → 1,3-bisbenzyloxy-2-methylbenzene (124317-11-9)

Conditions	Yield
With potassium phosphate In dimethyl sulfoxide at 60℃; for 1.33333h;	99%

2-methylbenzene-1,3-diol (608-25-3) + 1-O-acetyl-2,3,4-tri-O-benzyl-L-fucopyranose (151909-89-6) → 1,3-dihydroxy-2-methyl-4,6-bis(2,3,4-tri-O-benzyl-β-L-fucopyranosyl)benzene

Conditions	Yield
With calcium sulfate; scandium tris(trifluoromethanesulfonate) In 1,2-dichloro-ethane at -30 - 0℃; for 2.5h;	99%

2-methylbenzene-1,3-diol (608-25-3) + ethyl m-toluoylacetate (33166-79-9) → 7-hydroxy-8-methyl-4-(3-methylphenyl)-2H-chromen-2-one

Conditions	Yield
With sulfuric acid at 0 - 20℃; for 3h; Pechmann Condensation;	99%
With sulfuric acid In water at 20℃; for 3h; Pechmann Condensation;	88%

2-methylbenzene-1,3-diol (608-25-3) + N-(4,4-diethoxybutyl)-4-methylbenzenesulfonylamide (858005-68-2) → N,N',N'',N'''-((14,16,34,36,54,56,74,76-octahydroxy-15,35,55,75-tetramethyl-1,3,5,7(1,3)-tetrabenzenacyclooctaphane-2,4,6,8-tetrayl)tetrakis(propane-3,1-diyl))tetrakis(4-methylbenzenesulfonamide)

Conditions	Yield
With trifluoroacetic acid In chloroform at 20℃; for 24h;	99%

2-methylbenzene-1,3-diol (608-25-3) + 4-bromo-benzaldehyde (1122-91-4) + malononitrile (109-77-3) → C17H13BrN2O2

Conditions	Yield
With cholin hydroxide In water at 20℃; for 0.833333h;	99%
With choline acetate at 20℃; for 12h;	60%
With choline acetate at 20℃; for 12h;	60%

2-methylbenzene-1,3-diol (608-25-3) + ethyl 3-(3,4-dichloroisothiazol-5-yl)-3-oxopropionate → C13H7Cl2NO3S

Conditions	Yield
With trifluoroacetic acid Reflux;	99%

dimethylaminoacetaldehyde diethyl acetal (3616-56-6) + 2-methylbenzene-1,3-diol (608-25-3) → 1-amino-2,2-bis(2,4-dihydroxy-3-methylphenyl)-N,N-dimethylethane hydrochloride (1211322-47-2)

Conditions	Yield
With hydrogenchloride In ethanol; water at 90℃; for 12h;	98.5%

2-methylbenzene-1,3-diol (608-25-3) → 2-methyl-4-nitrosobenzene-1,3-diol (65882-00-0)

Conditions	Yield
With sulfuric acid; sodium nitrite In water	98%
With sulfuric acid; sodium nitrite In water at 0℃; for 0.5h;
With sulfuric acid; sodium nitrite In water at 20℃; for 0.75h;
With sulfuric acid; sodium nitrite In water at 0℃; for 2h;

2-methylbenzene-1,3-diol (608-25-3) + 4-bromo-benzaldehyde (1122-91-4) → 2,8,14,20-tetrakis(4-bromophenyl)-5,11,17,23-tetramethylpentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecaen-4,6,10,12,16,18,22,24-octol (216759-95-4)

Conditions	Yield
With hydrogenchloride In ethanol Cyclization; Heating;	98%

ethyl 4-nitrobenzoylacetate (838-57-3) + 2-methylbenzene-1,3-diol (608-25-3) → 7-hydroxy-8-methyl-4-(4-nitrophenyl)chromen-2-one

Conditions	Yield
With sulfuric acid at 0 - 20℃; for 1.5h; Pechmann Condensation;	98%

2-methylbenzene-1,3-diol (608-25-3) + acetic anhydride (108-24-7) → 2-methyl-1,3-phenylene diacetate (35236-42-1)

Conditions	Yield
With magnesium In neat (no solvent) at 25℃; for 18h; Temperature;	98%

2-methylbenzene-1,3-diol (608-25-3) + ethyl acetoacetate (141-97-9) → 4,8-dimethyl-7-hydroxycoumarin (4115-76-8)

Conditions	Yield
With ammonium cerium(IV) nitrate; silica gel for 0.05h; Pechmann reaction; microwave irradiation;	97%
With bispyridine cobalt(II) chloride for 0.0333333h; Pechmann condensation; Microwave irradiation; neat (no solvent);	97%
With silica gel for 0.0416667h; Pechmann condensation; Microwave irradiation;	97%

2-methylbenzene-1,3-diol (608-25-3) + ethyl 3-oxo-3-phenylpropionate (94-02-0) → 7-hydroxy-8-methyl-4-phenyl-chromen-2-one (21392-48-3)

Conditions	Yield
With sulfuric acid; silica gel at 80℃; for 0.5h; Pechmann condensation reaction;	97%
With potassium aluminum sulfate at 80℃; for 2h; Pechmann reaction;	95%
With sulfuric acid In water at 20℃; for 3h; Pechmann Condensation;	93%

2-methylbenzene-1,3-diol (608-25-3) + 4-chlorobenzaldehyde (104-88-1) + malononitrile (109-77-3) → 2-amino-7-hydroxy-8-methyl-4-(4-chlorophenyl)-4H-chromene-3-carbonitrile (753455-99-1)

Conditions	Yield
With cholin hydroxide In water at 20℃; for 0.666667h;	97%
With choline acetate at 20℃; for 9h;	70%
With choline acetate at 20℃; for 9h;	70%

2-methylbenzene-1,3-diol (608-25-3) + ortho-bromobenzaldehyde (6630-33-7) + malononitrile (109-77-3) → C17H13BrN2O2

Conditions	Yield
With cholin hydroxide In water at 20℃; for 0.666667h;	97%

2-methylbenzene-1,3-diol (608-25-3) + 2-chloro-benzaldehyde (89-98-5) + malononitrile (109-77-3) → C17H13ClN2O2

Conditions	Yield
With cholin hydroxide In water at 20℃; for 0.666667h;	97%

ethyl (2-chloroaceto)acetate (638-07-3) + 2-methylbenzene-1,3-diol (608-25-3) → 4-(chloromethyl)-7-hydroxy-8-methyl-2H-chromen-2-one (163684-50-2)

Conditions	Yield
zirconium(IV) chloride at 20℃; for 0.0833333h;	96%
With ammonium cerium(IV) nitrate; silica gel for 0.05h; Pechmann reaction; microwave irradiation;	94%
Stage #1: ethyl (2-chloroaceto)acetate With sulfuric acid at 0℃; Stage #2: 2-methylbenzene-1,3-diol at 20℃;	91%

2-methylbenzene-1,3-diol (608-25-3) + 2-nitro-benzaldehyde (552-89-6) + malononitrile (109-77-3) → C17H13N3O4

Conditions	Yield
With cholin hydroxide In water at 20℃; for 4.5h;	96%

carbon dioxide (124-38-9) + 2-methylbenzene-1,3-diol (608-25-3) → 2,4-dihydroxy-3-methylbenzoic acid (4707-49-7)

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 30℃; under 15001.5 Torr; for 24h; Kolbe-Schmidt Synthesis; Autoclave;	95%
With potassium hydrogencarbonate In water for 5h; Heating;	42%

2-methylbenzene-1,3-diol (608-25-3) → 4,6-diiodo-2-methyl-1,3-benzenediol (114971-54-9)

Conditions	Yield
With N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate In methanol; dichloromethane for 4h; Ambient temperature;	95%

ethyl 3,3-diethoxypropanoate (10601-80-6) + 2-methylbenzene-1,3-diol (608-25-3) → 7-hydroxy-8-methyl-2H-chromen-2-one (2732-17-4)

Conditions	Yield
Stage #1: ethyl 3,3-diethoxypropanoate; 2-methylbenzene-1,3-diol at 120℃; Stage #2: With sulfuric acid; trifluoroacetic acid at 20℃; for 0.5h;	95%

2-methylbenzene-1,3-diol (608-25-3) + acetoacetic acid methyl ester (105-45-3) → 4,8-dimethyl-7-hydroxycoumarin (4115-76-8)

Conditions	Yield
With Fe3O4-SiO2-HMTA nanomaterial In neat (no solvent) at 100℃; for 0.25h; Green chemistry;	95%
With 1-methyl-3-(4-sulfonylbutyl)-1H-imidazol-3-ium trifluoromethanesulfonate at 80℃; for 1.5h; Pechmann condensation;	92%
With potassium hydrogensulfate at 90℃; for 4h; Pechmann condensation;	92%
With poly(4-vinylpyridine)-supported copper iodide In neat (no solvent) at 80℃; for 0.25h; Pechmann Condensation; Green chemistry;	87%

(η6-chlorobenzene)(η5-cyclopentadienyl)iron(II) hexafluorophosphate + 2-methylbenzene-1,3-diol (608-25-3) → 2-methyl-1,3-bis((η6-phenoxy-η5-cyclopentadienyl)iron)benzene hexafluorophosphate

Conditions	Yield
With ammonium hexafluorophosphate; potassium carbonate In water; N,N-dimethyl-formamide addn. of the Fe-complex and ligand to K2CO3 and DMF, stirring for 12 h at room temp. under N2, filtn. into aq. HCl, pptn., addn. of acetone, evapn. (vac.) and addn. of a aq. soln. of NH4PF6; filtn., washing with cold water, drying for several hours under vacuum, washing (Et2O), further drying, elem. anal.;	95%

Upstream product

• 6971-52-4 3-methoxy-2-methylphenol 
• 116371-82-5 2-hydroxy-4-methoxy-3-methylbenzoic acid 
• 10034-85-2 hydrogen iodide 
• 67-56-1 methanol 
• 108-46-3 recorcinol 
• 69321-60-4 2,6-dibromotoluene 
• 118-69-4 2,6-dichlorotoluene 
• 3260-87-5 3-chloro-o-cresol 
• 94-74-6 MCPA 
• 1193-55-1 2-methylcyclohexane-1,3-dione 
• 4435-88-5 3-formyl-2, 4-dihydroxybenzoic acid 
• 39503-26-9 5-carbomethoxy-6-hydroxysalicylaldehyde 
• 2150-47-2 methyl 2,4-dihydroxybenzoate 
• 89-86-1 4-hydroxysalicylic acid 

Downstream Products

• 2913-48-6 2-hydroxy-3-methyl-1,4-benzoquinone 
• 4115-76-8 4,8-dimethyl-7-hydroxycoumarin 
• 39581-98-1 2,4-dihydroxy-3-methylphenylbenzylketone 
• 10139-84-1 1-(2,4-dihydroxy-3-methylphenyl)ethanone 
• 136498-54-9 2-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-(2,4-dihydroxy-3-methyl-phenyl)-ethanone 
• 74683-25-3 3-hydroxy-2-methyl-2'-nitrodiphenyl ether 
• 6971-52-4 3-methoxy-2-methylphenol 
• 63876-46-0 1-(2,4-dihydroxy-3-methylphenyl)propan-1-one 
• 6248-20-0 2,4-dihydroxy-3-methylbenzaldehyde 
• 312911-49-2 N-(7-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl)-benzamide 

Relevant articles and documents

Method for synthesizing M-hydroxyanisole

The invention provides a method for synthesizing M-hydroxyanisole. Belong to organic synthesis technical field. The synthesis method comprises the following steps: a vapor phase mixture of resorcinol and methanol is subjected to alkylation reaction through a metal phosphate - alumina fixed phase catalyst to obtain m-hydroxyanisole. The method adopts the gas-solid phase alkylation method to synthesize the M-hydroxyanisole without separating the reaction product from the catalyst, has the characteristic of continuous reaction, and can realize continuous production in the industrial production process. The method utilizes the acid-base catalytic activity center on the surface of the stationary phase catalyst to catalyze the reaction of resorcinol and methanol, and has high resorcinol conversion rate. The method has the advantage of high selectivity of m-hydroxyanisole. Methanol is used as a methylation reagent, and the method is environmentally friendly, low in cost and high in economic benefit.

Method for synthesizing 2,6-dihydroxytoluene by using waste acid

The invention discloses a method for synthesizing 2,6-dihydroxytoluene by using waste acid mechanically. According to the method, 3-chloro-2-methylaniline is taken as a raw material, an intermediate 3-chloro-2-methylphenol is synthesized through diazotization and hydrolysis, the reaction is optimized in the alkali fusion, acidification and refining processes, the mechanical application of waste acid and a solvent in the reaction and the optimization of a refining scheme are emphatically optimized, the yield is effectively improved, three wastes are reduced, and 2,6-dihydroxytoluene is synthesized. The method provided by the invention greatly reduces the generation of acidic wastewater, better meets the requirement of environmental protection, and effectively increases the yield of the product, and the quality of the product reaches 99.0-99.5%.

Synthesis method of 2,6-dihydroxytoluene

The invention belongs to the technical field of organic chemical synthesis, and particularly relates to a synthesis method of 2,6-dihydroxytoluene. The synthesis process comprises the following steps: S1, mixing 2,6-dihalogenated toluene, alkali, a heavy metal salt catalyst and an adsorbent, and heating and hydrolyzing to obtain a salt solution of 2,6-dihydroxytoluene; S2, adjusting the pH value of the 2,6-dihydroxytoluene salt solution obtained in the previous step to be weakly acidic by using an acid, separating a separated solid, and purifying to obtain a pure product of 2,6-dihydroxytoluene. The adopted main raw materials, such as 2,6-dichlorotoluene, cuprous chloride, sodium dodecyl sulfate and potassium hydroxide, are common chemical raw materials in the market, and are cheap, easy to obtain and wide in source; the synthesis route is short, steps are few, operation is simple, and production cost is greatly saved; reaction conditions are mild, and industrial production is facilitated; the process route is less in three wastes, the catalyst and the adsorbent can be repeatedly used, emission of the three wastes is further reduced, and the method is environment-friendly; the yield of the whole route is high, and the cost advantage is remarkable.