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CAS

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6080-33-7

Sinomenine Hydrochloride, also known as Sinomenine, is a natural plant alkaloid derived from the root of Sinomenium acutum. It is a white solid with anti-inflammatory and analgesic properties. Sinomenine Hydrochloride activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without causing gastrointestinal adverse events. It also impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain. Additionally, it enhances the bioavailability of some compounds, at least in part through an inhibition of drug export by transporters like P-glycoprotein.

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  • 6080-33-7 Structure

  • Basic information

    1. Product Name: SINOMENINE HYDROCHLORIDE
    2. Synonyms: (9a,13a,14a)-4-Hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-6-one hydrochloride;SINOMENINE HYDROCHLORIDE;SINOMENINE HCL;Tuduranine Hydrochloride;(9α,13α,14α)- 7,8-Didehydro-4- hydroxy-3,7-diMet;7,8-Didehydro-4-hydroxy-3,7-diMethoxy-17-Methyl- 9α,13α,14α-Morphinan-6-one Hydrochloride;Sinomenine hydrochloride (Cucoline hydrochloride)
    3. CAS NO:6080-33-7
    4. Molecular Formula: C19H23NO4*ClH
    5. Molecular Weight: 365.85
    6. EINECS: N/A
    7. Product Categories: pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;Alkaloids;APIs;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent
    8. Mol File: 6080-33-7.mol

  • Chemical Properties

    1. Melting Point: 231.0 to 235.0 °C
    2. Boiling Point: 536 °C at 760 mmHg
    3. Flash Point: 278 °C
    4. Appearance: white to beige/
    5. Density: N/A
    6. Vapor Pressure: 3.59E-11mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: 2-8°C
    9. Solubility: H2O: soluble20mg/mL, clear
    10. CAS DataBase Reference: SINOMENINE HYDROCHLORIDE(CAS DataBase Reference)
    11. NIST Chemistry Reference: SINOMENINE HYDROCHLORIDE(6080-33-7)
    12. EPA Substance Registry System: SINOMENINE HYDROCHLORIDE(6080-33-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: 24/25
    4. WGK Germany: 3
    5. RTECS: QD2163000
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 6080-33-7(Hazardous Substances Data)

6080-33-7 Usage

Uses

Used in Pharmaceutical Industry:
Sinomenine Hydrochloride is used as an anti-inflammatory and analgesic agent for the treatment of rheumatoid arthritis. It helps alleviate inflammation, reduce joint stiffness and pain, and modulate cytokine generation.
Used in Drug Delivery Systems:
Sinomenine Hydrochloride is used as an enhancer of bioavailability for certain compounds. It improves the absorption and bioavailability of these compounds by inhibiting drug export through transporters like P-glycoprotein, thus potentially increasing their therapeutic efficacy.
Used in Pain Management:
Sinomenine Hydrochloride is used as a pain reliever for various conditions, including but not limited to, musculoskeletal and joint pain. Its analgesic effect makes it a valuable component in pain management therapies.
Used in Immunosuppression:
Sinomenine Hydrochloride is used as an immunosuppressive agent due to its ability to impair signaling through NF-κB. This property can be beneficial in conditions where the immune system's response needs to be modulated or reduced.

Purification Methods

Crystallise the salt from water (1g/1.5mL) or EtOH. The free base [115-53-7] M 329.4, has m 161o (from EtOH) (and again at 182o) after crystallisation from *C6H6, and [] D 20 -78.9o (c 1, EtOH). The picrate has m 159-162o(dec) (from H2O). [Beilstein 21 II 470, 21 III/IV 6670.]

Check Digit Verification of cas no

The CAS Registry Mumber 6080-33-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,8 and 0 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6080-33:
(6*6)+(5*0)+(4*8)+(3*0)+(2*3)+(1*3)=77
77 % 10 = 7
So 6080-33-7 is a valid CAS Registry Number.
InChI:InChI=1/C19H23NO4.ClH/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19;/h4-5,9,12-13,22H,6-8,10H2,1-3H3;1H/t12-,13-,19+;/m1./s1

6080-33-7 Well-known Company Product Price

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  • TCI America

  • (S0926)  Sinomenine Hydrochloride  >98.0%(HPLC)(T)

  • 6080-33-7

  • 1g

  • 590.00CNY

  • Detail

  • TCI America

  • (S0926)  Sinomenine Hydrochloride  >98.0%(HPLC)(T)

  • 6080-33-7

  • 5g

  • 1,990.00CNY

  • Detail

6080-33-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Sinomenine Hydrochloride

1.2 Other means of identification

Product number -
Other names Cucoline, hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6080-33-7 SDS

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