608141-42-0Relevant articles and documents
CRYSTAL FORMS OF THIOPHENE DERIVATIVES
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Paragraph 0271, (2021/05/14)
Disclosed is crystal form I of compound (S)—N-[5-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-4,6-dioxo-5,6-dihydro-4H-thieno[3,4-c]pyrrole-1-yl]acetamide.
Synthesis method of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl) ethylamine
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Paragraph 0164-0176, (2021/01/29)
The invention relates to a synthetic method of (S)-1-(3-ethoxy-4-methoxy phenyl)-2-(methylsulfonyl) ethylamine. The method comprises the following steps: mixing 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl) vinylamine, a chiral catalyst, an acid and a solvent, and performing reacting; the structural formula of the chiral catalyst is shown as a formula (I), wherein R is selected from a hydrogen atom, an alkyl group, an aromatic ring, an alkoxy group, a halogen atom, an amino group, a cyano group, a hydroxyl group, a trifluoromethyl group, a nitro group, an ester group or an amido group. (S)-1-(3-ethoxy-4-methoxy phenyl)-2-(methylsulfonyl) ethylamine with high chiral purity can be generated in one step, meanwhile, the product is easy to separate and purify, and the yield is high. In addition, the method is mild in reaction condition, stable in process, simple and safe in reaction operation, low in production cost, simple and feasible in three-waste treatment, environment-friendly, easily available in raw materials, low in production cost and suitable for industrial production.
NOVEL ISOINDOLINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
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Paragraph 0142-0143, (2020/01/22)
Disclosed are a novel isoindoline derivative, a pharmaceutical composition and use thereof. The compound of formula I, or the pharmaceutically acceptable salt, solvate, polymorph, co-crystal, stereoisomer, isotopic compound, metabolite or prodrug thereof disclosed in the invention can regulate the generation and/or activity of PDE4 and/or TNF-α so as to effectively treat cancer and inflammatory diseases.