610791-44-1Relevant articles and documents
General and cost-effective synthesis of 1-heteroaryl/arylcycloalkylamines and their broad applications
Zhang, Dehui,Zheng, Hongchao,Wang, Xiaodong
, p. 1941 - 1953 (2016/04/05)
A general and cost-effective route has been developed to synthesize 1-heteroarylsubstituted cycloalkylamines from readily available heteroarylacetate in good yields. This synthesis features a LHMDS promoted cyclization and one-pot hydrolysis/Curtius rearr
N-(arylacetyl)-biphenylalanines as potent VLA-4 antagonists.
Li, Bing,de Laszlo, Stephen E,Kamenecka, Theodore M,Kopka, Ihor E,Durette, Philippe L,Lanza Jr., Thomas,MacCoss, Malcolm,Tong, Sharon,Mumford, Richard A,McCauley, Ermengilda D,Van Riper, Gail,Schmidt, John A,Hagmann, William K
, p. 2141 - 2144 (2007/10/03)
A series of potent N-(aralkyl-, arylcycloalkyl-, and heteroaryl-acyl)-4-biphenylalanine VLA-4 antagonists was prepared by rapid analogue methods using solid-phase chemistry. Further optimization led to several highly potent compounds (IC(50) 1 nM). Evalu