Welcome to LookChem.com Sign In|Join Free

CAS

  • or

611-64-3

Post Buying Request

611-64-3 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

611-64-3 Usage

Chemical Properties

Yellow crystalline powder

Uses

9-Methylacridine is an derivative of Acridine (A190900), a quinoline derivative used as manufacturing dyes and as an intermediate for the synthesis of antileishmanial agents.

Synthesis Reference(s)

Tetrahedron Letters, 9, p. 4625, 1968 DOI: 10.1016/S0040-4039(00)72895-4

Check Digit Verification of cas no

The CAS Registry Mumber 611-64-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 1 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 611-64:
(5*6)+(4*1)+(3*1)+(2*6)+(1*4)=53
53 % 10 = 3
So 611-64-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H11N/c1-10-11-6-2-4-8-13(11)15-14-9-5-3-7-12(10)14/h2-9H,1H3

611-64-3 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (H33718)  9-Methylacridine, 96%   

  • 611-64-3

  • 250mg

  • 410.0CNY

  • Detail
  • Alfa Aesar

  • (H33718)  9-Methylacridine, 96%   

  • 611-64-3

  • 1g

  • 1142.0CNY

  • Detail
  • USP

  • (1424084)  9-Methylacridine  United States Pharmacopeia (USP) Reference Standard

  • 611-64-3

  • 1424084-25MG

  • 14,500.98CNY

  • Detail

611-64-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 9-Methylacridine

1.2 Other means of identification

Product number -
Other names 9-METHYLACRIDINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:611-64-3 SDS

611-64-3Synthetic route

C14H12BrN
1433773-40-0

C14H12BrN

9-methyl-acridine
611-64-3

9-methyl-acridine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; ruphos In 1,4-dioxane; water at 110℃; for 12h; Inert atmosphere; Microwave irradiation;100%
N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide
1433772-22-5

N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide

1,2-dibromobenzene
583-53-9

1,2-dibromobenzene

9-methyl-acridine
611-64-3

9-methyl-acridine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; ruphos In 1,4-dioxane; water at 110℃; for 12h; Reagent/catalyst; Temperature; Microwave irradiation; Inert atmosphere;98%
dibenzoazepine
256-96-2

dibenzoazepine

A

9-methyl-acridine
611-64-3

9-methyl-acridine

B

9,10-dihydrodibenzazepine
494-19-9

9,10-dihydrodibenzazepine

Conditions
ConditionsYield
With iodine; hypophosphorous acid In acetic acid for 24h; Heating;A 92%
B 8%
Diphenyliodonium triflate
66003-76-7

Diphenyliodonium triflate

2-aminoacetophenone
551-93-9

2-aminoacetophenone

9-methyl-acridine
611-64-3

9-methyl-acridine

Conditions
ConditionsYield
With copper(l) iodide In 1,2-dichloro-ethane at 65℃; for 12h; Reagent/catalyst; Temperature; Solvent; Friedel-Crafts Alkylation; Inert atmosphere; Sealed tube;92%
With copper(l) iodide In 1,2-dichloro-ethane at 65℃; Temperature; Reagent/catalyst; Sealed tube; Inert atmosphere;92%
1,2-Diiodobenzene
615-42-9

1,2-Diiodobenzene

N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide
1433772-22-5

N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide

9-methyl-acridine
611-64-3

9-methyl-acridine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; ruphos In 1,4-dioxane; water at 110℃; for 12h; Microwave irradiation; Inert atmosphere;90%
N-(1-phenylethylidene)aniline
1749-19-5

N-(1-phenylethylidene)aniline

Phenyl azide
622-37-7

Phenyl azide

9-methyl-acridine
611-64-3

9-methyl-acridine

Conditions
ConditionsYield
With tris(acetonitrile)(η5-pentamethylcyclopentadienyl)rhodium(III) hexafluoroantimonate; acetic anhydride In 1,2-dichloro-ethane at 110℃; for 20h; Inert atmosphere;87%
2-aminoacetophenone
551-93-9

2-aminoacetophenone

phenylboronic acid
98-80-6

phenylboronic acid

9-methyl-acridine
611-64-3

9-methyl-acridine

Conditions
ConditionsYield
With copper(II) bis(trifluoromethanesulfonate) In 1,1,2,2-tetrachloroethane at 100℃; for 14h; Sealed tube;86%
Stage #1: 2-aminoacetophenone; phenylboronic acid With copper diacetate In 2,2,2-trifluoroethanol at 20℃; for 12h;
Stage #2: With t-butyl bromide In 2,2,2-trifluoroethanol at 20℃; for 24h;
85%
acetic acid
64-19-7

acetic acid

diphenylamine
122-39-4

diphenylamine

9-methyl-acridine
611-64-3

9-methyl-acridine

Conditions
ConditionsYield
With 2,2-dimethoxy-propane; zinc(II) chloride In neat (no solvent) at 100℃; for 0.133333h; Bernthsen Acridine Synthesis; Microwave irradiation; Green chemistry;84%
With zinc(II) chloride at 220℃; for 17h;81%
With zinc(II) chloride at 220℃; for 17h;81%
10-ethyl-9-methylacridinium ethosulfate

10-ethyl-9-methylacridinium ethosulfate

9-methyl-acridine
611-64-3

9-methyl-acridine

Conditions
ConditionsYield
With sodium acetate In ethanol for 2h; Heating;77%
2-chloro-N-(2-vinylphenyl)aniline
1246225-46-6

2-chloro-N-(2-vinylphenyl)aniline

9-methyl-acridine
611-64-3

9-methyl-acridine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate In toluene at 100℃; for 24h; Inert atmosphere;77%
cyclohexanone
108-94-1

cyclohexanone

2-aminoacetophenone
551-93-9

2-aminoacetophenone

9-methyl-acridine
611-64-3

9-methyl-acridine

Conditions
ConditionsYield
With 2-aminopyridine; palladium(II) trimethylacetate; oxygen; citric acid In toluene at 110℃; under 760.051 Torr; for 18h;65%
With 2-aminopyridine; palladium(II) trifluoroacetate; oxygen; citric acid In toluene at 100℃; for 12h;
dibenzoazepine
256-96-2

dibenzoazepine

9-methyl-acridine
611-64-3

9-methyl-acridine

Conditions
ConditionsYield
at 950℃; under 0.009 Torr; for 0.5h;60%
2-bromo-1-chlorobenzene
694-80-4

2-bromo-1-chlorobenzene

N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide
1433772-22-5

N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide

9-methyl-acridine
611-64-3

9-methyl-acridine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; ruphos In 1,4-dioxane; water at 110℃; for 12h; Microwave irradiation; Inert atmosphere;55%
N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide
1433772-22-5

N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide

2-iodophenyltrifluoromethanesulfonic acid
129112-26-1

2-iodophenyltrifluoromethanesulfonic acid

9-methyl-acridine
611-64-3

9-methyl-acridine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); lithium chloride; lithium tert-butoxide; ruphos In 1,4-dioxane; water at 110℃; for 12h; Microwave irradiation; Inert atmosphere;55%
dibenzoazepine
256-96-2

dibenzoazepine

acetic acid
64-19-7

acetic acid

A

9-methyl-acridine
611-64-3

9-methyl-acridine

B

5-acetyliminodibenzyl
13080-75-6

5-acetyliminodibenzyl

C

9-methyl-9,10-dihydroacridine
4217-52-1

9-methyl-9,10-dihydroacridine

D

9,10-dihydrodibenzazepine
494-19-9

9,10-dihydrodibenzazepine

Conditions
ConditionsYield
With iodine; hypophosphorous acid for 96h; Heating;A 18%
B 9%
C 20%
D 47%

611-64-3Relevant articles and documents

New spiroacridine derivatives with DNA-binding and topoisomerase I inhibition activity

Sabolová, Danica,Vilková, Mária,Imrich, Ján,Poto?ňák, Ivan

, p. 5592 - 5595 (2016)

Eight spiroacridine derivatives containing the isoxazoline ring were synthesized and characterized using elemental analysis, IR, UV–vis, and NMR measurements. Their interactions with calf thymus DNA were extensively studied by various spectroscopic techni

Synthesis, DNA binding and topoisomerase i inhibition activity of thiazacridine and imidazacridine derivatives

Lafayette, Elizabeth Almeida,De Almeida, Sinara Monica Vitalino,Da Rocha Pitta, Marina Galdino,Beltrao, Eduardo Isidoro Carneiro,Da Silva, Teresinha Goncalves,De Moura, Ricardo Olimpio,Da Rocha Pitta, Ivan,De Carvalho Junior, Luiz Bezerra,De Lima, Maria Do Carmo Alves

, p. 15035 - 15050 (2013)

Thiazacridine and imidazacridine derivatives have shown promising results as tumors suppressors in some cancer cell lines. For a better understanding of the mechanism of action of these compounds, binding studies of 5-acridin-9-ylmethylidene-3-amino-2- th

-

Lehr,Conway

, p. 2726,2728 (1977)

-

A distinctive example of the cooperative interplay of structure and environment in tuning of intramolecular charge transfer in second-order nonlinear optical chromophores

Abbotto, Alessandro,Beverina, Luca,Bradamante, Silvia,Facchetti, Antonio,Klein, Christopher,Pagani, Giorgio A.,Redi-Abshiro, Mesfin,Wortmann, Ruediger

, p. 1991 - 2007 (2003)

The strongly enhanced cooperative influence of medium polarity and organic structural design on the first hyperpolarizability β of a novel family of highly polarizable azinium-(CH=CH-thienyl)-dicyanomethanido chromophores 1-3 is described. The dyes can be

Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents

Song, Di,Zhang, Nan,Zhang, Panpan,Zhang, Na,Chen, Weijin,Zhang, Long,Guo, Ting,Gu, Xiaotong,Ma, Shutao

, (2021/05/10)

With the increasing incidence of antibiotic resistance, new antibacterial agents having novel mechanisms of action hence are in an urgent need to combat infectious diseases caused by multidrug-resistant (MDR) pathogens. Four novel series of substituted 9-arylalkyl-10-methylacridinium derivatives as FtsZ inhibitors were designed, synthesized and evaluated for their antibacterial activities against various Gram-positive and Gram-negative bacteria. The results demonstrated that they exhibited broad-spectrum activities with substantial efficacy against MRSA and VRE, which were superior or comparable to the berberine, sanguinarine, linezolid, ciprofloxacin and vancomycin. In particular, the most promising compound 15f showed rapid bactericidal properties, which avoid the emergence of drug resistance. However, 15f showed no inhibitory effect on Gram-negative bacteria but biofilm formation study gave possible answers. Further target identification and mechanistic studies revealed that 15f functioned as an effective FtsZ inhibitor to alter the dynamics of FtsZ self-polymerization, which resulted in termination of the cell division and caused cell death. Further cytotoxicity and animal studies demonstrated that 15f not only displayed efficacy in a murine model of bacteremia in vivo, but also no significant hemolysis to mammalian cells. Overall, this compound with novel skeleton could serve as an antibacterial lead of FtsZ inhibitor for further evaluation of drug-likeness.

New reductive rearrangement of: N-arylindoles triggered by the grubbs-stoltz reagent et3sih/kotbu

Allison, Mark,Arokianathar, Jude N.,Dimitrova, Daniela,Kolodziejczak, Krystian,Leach, Stuart G.,Murphy, John A.,Parkinson, John A.,Poole, Darren L.,Smith, Andrew J.,Tuttle, Tell,Young, Allan

, p. 3719 - 3726 (2020/04/20)

N-Arylindoles are transformed into dihydroacridines in a new type of rearrangement, through heating with triethylsilane and potassium tert-butoxide. Studies indicate that the pathway involves (i) the formation of indole radical anions followed by fragmentation of the indole C2-N bond, and (ii) a ring-closing reaction that follows a potassium-ion dependent hydrogen atom transfer step. Unexpected behaviors of 'radical-trap' substrates prove very helpful in framing the proposed mechanism.

9-Substituted acridines as effective corrosion inhibitors for mild steel: Electrochemical, surface morphology, and computational studies

Li, Hui-Jing,Liu, Ying,Wang, Li-Juan,Wu, Yan-Chao,Zhang, Weiwei,Zhang, Yinlin

, p. 6464 - 6474 (2020/05/13)

Three 9-substituted acridines, namely 9-carboxyacridine (CA), 9-methylacridine (MA), and 9-aminoacridine (AA), were designed and synthesized for the development of effective inhibitors for mild steel corrosion in a 15% HCl solution. The corrosion-resistance ability was tested by weight-loss tests, electrochemical techniques, surface-topography analyses (SEM, SECM, and XPS), and contact angle measurements. The results indicated the inhibition performance followed the order of η(AA) > η(MA) > η(CA), and these acridines acted as mixed type inhibitors with a predominant restrained cathode process. The adsorption of the three acridines on a mild steel surface obeyed the Langmuir adsorption isotherm and involved both physisorption and chemisorption modes. Surface analysis and characterization confirmed the existence of an adsorbed film. Quantum chemical calculations were performed to provide mechanistic insights into the roles of the different substituents (-COOH, -CH3, and -NH2) on the corrosion-inhibition behavior of the three acridines. Molecular dynamics (MD) simulations were carried out to explore the configurational adsorption behavior of these 9-substituted acridines on the Fe(110) surface.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 611-64-3