61196-37-0

Basic information

• Product Name: 1,2,3,6,7,11B-HEXAHYDRO-4H-PYRAZINO(2,1-A)ISOQUINOLINE-4-ONE
• Synonyms: 1,2,3,6,7,11B-HEXAHYDRO-4H-PYRAZINO(2,1-A)ISOQUINOLINE-4-ONE;1,2,3,6,7,11b-Hexahydro-4H-pyrazino[2,1-]isoquinoline-4-one;1,2,3,6,7,11β-hexahydro-4H-pyrazino[2,1-a]isoquinoline-4-one;1,2,3,6,7,11β-hexahydro-4H-pyrazino[2,1-α]isoquinoline-4-one;rac-PraziquanaMine;1,2,3,6,7,11b-Hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one;DL-PraziquanaMine;2,3,6,7-Tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one
• CAS NO: 61196-37-0
• Molecular Formula: C₁₂H₁₄N₂O
• Molecular Weight: 202.25
• EINECS: 928-228-4
• Product Categories: Heterocycles;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 61196-37-0.mol
• Article Data: 24

Chemical Properties

• Melting Point: 116.8-118.4℃
• Boiling Point: 399.7°C at 760 mmHg
• Flash Point: 195.5°C
• Appearance: /
• Density: 1.24±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 1.35E-06mmHg at 25°C
• Refractive Index: 1.632
• Storage Temp.: -20°C Freezer
• Solubility: Dichloromethane (Slightly), Chloroform (Slightly), Methanol (Slightly)
• PKA: 7.44±0.20(Predicted)
• CAS DataBase Reference: 1,2,3,6,7,11B-HEXAHYDRO-4H-PYRAZINO(2,1-A)ISOQUINOLINE-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,6,7,11B-HEXAHYDRO-4H-PYRAZINO(2,1-A)ISOQUINOLINE-4-ONE(61196-37-0)
• EPA Substance Registry System: 1,2,3,6,7,11B-HEXAHYDRO-4H-PYRAZINO(2,1-A)ISOQUINOLINE-4-ONE(61196-37-0)

Safety Data

• Hazardous Substances Data: 61196-37-0(Hazardous Substances Data)

Usage

Uses

Praziquanamine, as the main intermediate for synthesizing antiparasitic agent Praziquantel (P702095).

InChI:InChI=1/C12H14N2O/c15-12-8-13-7-11-10-4-2-1-3-9(10)5-6-14(11)12/h1-4,11,13H,5-8H2

Upstream product

• 55375-91-2 (-)-2-Benzoyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline 
• 62885-88-5 α-amino-N-(2-phenylethyl)acetamide 
• 99746-73-3 (S)-(-)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one 
• 90142-14-6 N-2-phenylethyl 2-N-(2,2-dimethoxyethylamino)acetamide hydrochloride 
• 1380603-46-2 2-[(2,2-dimethoxyethyl)benzylamino]-N-phenethylacetamide 
• 13156-95-1 2-chloro-N-phenethylacetamide 
• 210223-97-5 2-[(2,2-dimethoxyethyl)amino]-N-(2-phenylethyl)acetamide hydrochloride 
• 64-04-0 phenethylamine 
• 87693-78-5 4-benzoyl-2,6-dioxo-1-phenethyl piperazine 
• 87693-80-9 1-(2-phenylethyl)-4-benzoyl-2-hydroxypiperazin-6-one 
• 87693-77-4 4-acetyl-2,6-dioxo-1-phenethyl piperazine 
• 87693-79-6 1-(2-phenyl)ethyl-4-acetyl-2-hydroxypiperazine-6-one 
• 17376-04-4 2-phenethyl iodide 
• 106148-27-0 1-(2-phenylethyl)-4-benzyl-2,6-piperazinedione 

Downstream Products

• 55268-74-1 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one 
• 5234-86-6 1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline 
• 1240039-28-4 2-(4-fluorobenzyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one hydrochloride 
• 60743-58-0 4-hydroxyl-praziquantel 
• 1622136-46-2 (S)-praziquanamine-hemi-dibenzoyl-D-tataric acid salt 
• 1622136-46-2 (R)-praziquanamine-hemi-dibenzoyl-L-tataric acid salt 
• 1622136-46-2 (S)-praziquanamine-hemi-dibenzoyl-L-tataric acid salt 
• 1246343-36-1 2-(cyclohexane-d11-carbonyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one 
• 1399880-38-6 (R)-2-(cyclohexane-d11-carbonyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one 
• 1622136-46-2 (R)-praziquanamine dibenzoyl-L-tartaric acid salt 
• 1622136-46-2 (S)-praziquanamine dibenzoyl-D-tartaric acid salt 
• 1622136-46-2 (R)-praziquanamine dibenzoyl-D-tartaric acid salt 
• 1622136-46-2 (S)-praziquanamine dibenzoyl-L-tartaric acid salt 
• 57452-32-1 (+)-2-(4-oxocyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one 

Relevant articles and documents

CONJUGATES

The present invention provides a conjugate of formula (I) and itsuse in methods of treatment, and also methods for delivering an active agent into a cell. The methods may be used to deliver an active agent into a nematode, flatworm, parasite or bacterium. The conjugate of formula (I) is: (formula (I)), wherein -D- is C1-4 alkylene or C2-4 alkenylene, preferably C2-4 alkenylene, where the alkylene or alkenylene is optionally substituted with alkyl or halo; A- is an active agent for delivery; and -RA, -RB, -RT1, -RT2, -R1, -R2, -R3, -X- and -L- are as defined herein.

Recovery preparation method of racepiquamine

The invention discloses a recovery preparation method of racepiquamine-1. The preparation method comprises the following steps: dissolving a waste material S-piquamine intermediate-1 as an initial rawmaterial in a solvent; and carrying out reaction at a proper temperature in the presence of a catalyst and hydrogen at a certain pressure to prepare the piquamine intermediate-1 of racemate. The formula is as shown in the description. The configured piquamine S-1 which is not needed is efficiently, conveniently and fully operated and recovered with a high yield to obtain a racemate compound 1, and then the racemate compound is used again to prepare levopraziquantel, so that wastes can be turned into wealth, and therefore, the generation cost of the levopraziquantel is saved greatly.

One-pot palladium-catalyzed racemization of (S)-praziquanamine: A key intermediate for the anthelmintic agent (R)-praziquantel

An one-pot palladium-catalyzed procedure for racemization of (S)-praziquanamine, which is the undesired enantiomer and produced during the resolution step for preparing the anthelmintic drug (R)-praziquantel, has been developed through dehydrogenation of