61348-28-5

Basic information

• Product Name: Boc-D-Glutamine
• Synonyms: Nalpha-BOC-D-Glutamine,98%;(R)-5-amino-2-(tert-butoxycarbonylamino)-5-oxopentanoic acid;N-α-Boc-D-glutamine;Boc-D-Gln-OH (Boc-D-GlutaMine);Boc-D-Gln-OH >=98.0%;(2R)-5-amino-2-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoic acid;(2R)-5-amino-2-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxo-pentanoic acid;Boc-D-glutamine≥ 98% (HPLC)
• CAS NO: 61348-28-5
• Molecular Formula: C₁₀H₁₈N₂O₅
• Molecular Weight: 246.26
• EINECS: 230-006-0
• Product Categories: Amino Acids;Boc-Amino Acids and Derivative
• Mol File: 61348-28-5.mol

Chemical Properties

• Melting Point: 117-119°C
• Boiling Point: 389.26°C (rough estimate)
• Flash Point: 261.7 °C
• Appearance: /
• Density: 1.2430 (rough estimate)
• Refractive Index: 1.4550 (estimate)
• Storage Temp.: Store at RT.
• Solubility: Soluble, 1mmol in 2mL DMF. Soluble in chloroform and methanol.
• PKA: 3.84±0.10(Predicted)
• BRN: 1981311
• CAS DataBase Reference: Boc-D-Glutamine(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-D-Glutamine(61348-28-5)
• EPA Substance Registry System: Boc-D-Glutamine(61348-28-5)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 61348-28-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Boc-D-Glutamine is used as an intermediate in the synthesis of various pharmaceutical compounds for [application reason]. Its N-Boc protection allows for selective deprotection and functionalization, making it a valuable building block in the development of new drugs.
Used in Biochemical Research:
In the field of biochemical research, Boc-D-Glutamine is used as a research tool for studying the role of D-Glutamine in biological processes and its interactions with enzymes and other biomolecules. This helps in understanding the mechanisms of various diseases and potential therapeutic targets.
Used in Enzyme Synthesis:
Boc-D-Glutamine is used as a substrate in the synthesis of enzymes that specifically utilize D-Glutamine, allowing researchers to study the enzyme's activity and optimize its production for industrial or medical applications.
Used in Food Industry:
In the food industry, Boc-D-Glutamine can be used as an additive to enhance the flavor and texture of certain products, as D-Glutamine is known to be present in fermented foods like cheese, wine, and vinegars.
Used in Cosmetics Industry:
Boc-D-Glutamine may also find applications in the cosmetics industry, where it can be used as an ingredient in skincare products due to its potential benefits for skin health and its role in cellular metabolism.

Upstream product

• 5959-95-5 D-Glutamin 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 61543-21-3 BOC-D-glutamine benzyl ester 
• 499775-48-3 (R)-2-((R)-2-tert-Butoxycarbonylamino-4-carbamoyl-butyrylamino)-succinic acid dibenzyl ester 
• 499775-47-2 (S)-2-((R)-2-tert-Butoxycarbonylamino-4-carbamoyl-butyrylamino)-succinic acid dibenzyl ester 
• 499775-50-7 (R)-2-((R)-2-tert-Butoxycarbonylamino-4-carbamoyl-butyrylamino)-pentanedioic acid dibenzyl ester 
• 499775-49-4 (S)-2-((R)-2-tert-Butoxycarbonylamino-4-carbamoyl-butyrylamino)-pentanedioic acid dibenzyl ester 
• 918314-48-4 (R)-2-Amino-4-carbamoyl-butyric acid benzyl ester 
• 59524-68-4 (R)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-4-carbamoyl-butyric acid benzyl ester 
• 128753-64-0 L-alanyl-D-glutamine benzyl ester hydrochloride 
• 128753-65-1 2-N-acetyl-1-α-O-allyl-4,6-O-isopropylidenemuramyl-L-alanyl-D-glutamine benzyl ester 
• 128753-67-3 (2R)-benzyl 2--4-cyanobutanoate 
• 128753-66-2 (2R)-benzyl 2--4-cyanobutanoate 
• 128753-69-5 (2R,2R'')-benzyl 2-(benzyloxy)phosphoryl>-4',6'-di-O-acetylmuramyl-L-alanyl)amino>-4-cyanobutanoate 
• 25691-37-6 (α)N-1,1-dimethylethoxycarbonyl-L-2,4-diaminobutyric acid 

Relevant articles and documents

Cγ(S/ R)-Bimodal Peptide Nucleic Acids (Cγ- bm-PNA) Form Coupled Double Duplexes by Synchronous Binding to Two Complementary DNA Strands

Peptide nucleic acids (PNAs) are linear equivalents of DNA with a neutral acyclic polyamide backbone that has nucleobases attached via tert-amide link on repeating units of aminoethylglycine. They bind complementary DNA or RNA with sequence specificity to form hybrids that are more stable than the corresponding DNA/RNA self-duplexes. A new type of PNA termed bimodal PNA [Cγ(S/R)-bm-PNA] is designed to have a second nucleobase attached via amide spacer to a side chain at Cγon the repeating aeg units of PNA oligomer. Cγ-bimodal PNA oligomers that have two nucleobases per aeg unit are demonstrated to concurrently bind two different complementary DNAs, to form duplexes from both tert-amide side and Cγside. In such PNA:DNA ternary complexes, the two duplexes share a common PNA backbone. The ternary DNA 1:Cγ(S/R)-bm-PNA:DNA 2 complexes exhibit better thermal stability than the isolated duplexes, and the Cγ(S)-bm-PNA duplexes are more stable than Cγ(R)-bm-PNA duplexes. Bimodal PNAs are first examples of PNA analogues that can form DNA2:PNA:DNA1 double duplexes via recognition through natural bases. The conjoined duplexes of Cγ-bimodal PNAs can be used to generate novel higher-level assemblies.

Adrenocorticotropin. 48. Synthesis and biological activity of [15,16 D lysine, 17,18 D arginine] adrenocorticotropin (1 19) and an all D retropeptide related to the amino terminal octadecapeptide of adrenocorticotropin

The peptide [15, 16-D-lysine, 17, 18-D-arginine]-adrenocorticotropin -(1-19) and an all-D-retropeptide related to the amino terminal octadecapeptide of adrenocorticotropin have been synthesized by the solid-phase method. The nonadecapeptide was shown to p