6139-84-0

Basic information

• Product Name: 4-CHLORO-BUTYRALDEHYDE
• Synonyms: 4-CHLORO-BUTYRALDEHYDE;4-chlorbutanal;4-chlorobutanal;Butanal, 4-chloro-
• CAS NO: 6139-84-0
• Molecular Formula: C₄H₇ClO
• Molecular Weight: 106.55078
• Mol File: 6139-84-0.mol
• Article Data: 63

Chemical Properties

• Boiling Point: 118.37°C (rough estimate)
• Flash Point: 51 °C
• Appearance: /
• Density: 1.1060
• Vapor Pressure: 2.68mmHg at 25°C
• Refractive Index: 1.4466 (estimate)
• CAS DataBase Reference: 4-CHLORO-BUTYRALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-BUTYRALDEHYDE(6139-84-0)
• EPA Substance Registry System: 4-CHLORO-BUTYRALDEHYDE(6139-84-0)

Safety Data

• Hazardous Substances Data: 6139-84-0(Hazardous Substances Data)

Usage

General Description

4-CHLORO-BUTYRALDEHYDE, also known as 4-chlorobutanal, is a chemical compound with the molecular formula C4H7ClO. It is a colorless to pale yellow liquid with a pungent odor, and is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 4-CHLORO-BUTYRALDEHYDE is also used in the production of fragrances and flavoring agents. It is a highly reactive compound and should be handled with care, as it can cause irritation to the skin, eyes, and respiratory system. Additionally, it is flammable and should be stored and handled according to proper safety protocols. Overall, 4-CHLORO-BUTYRALDEHYDE is an important chemical in various industrial processes and applications.

InChI:InChI=1/C4H7ClO/c5-3-1-2-4-6/h4H,1-3H2

Upstream product

• 4635-59-0 4-Chlorobutanoyl chloride 
• 928-51-8 4-Chloro-1-butanol 
• 3153-37-5 methyl 4-chlorobutyrate 
• 108-48-5 2,6-dimethylpyridine 
• 927-73-1 3-butenyl chloride 
• 31930-38-8 (E)-4-chlorobut-2-enal 
• 79-37-8 oxalyl dichloride 
• 54322-20-2 4-chloro-1-hydroxy-1-butanesulfonate sodium 
• 6139-83-9 4-chloro-1,1-diethoxybutane 
• 7440-05-3 palladium 
• 110-63-4 Butane-1,4-diol 
• 7647-01-0 hydrogenchloride 
• 75-07-0 acetaldehyde 
• 123-73-9 crotonaldehyde 

Downstream Products

• 3248-05-3 4,7-Dimethyl-1,10-phenanthroline 
• 2801-29-8 4-methyl-8-nitroquinoline 
• 84904-91-6 6-aza-1-azoniatricyclo<4.4.3.0^1,5>tridecane chloride 
• 82407-78-1 6-aza-1-azoniatricyclo<4.3.3.0^1,5>dodecane chloride 
• 81608-89-1 5-(2-chloropropyl)-3-hydroxy-4-methylfuran-2(5H)-one 
• 75052-88-9 1-Chlor-(Z)-4-decen 
• 100231-27-4 7-chlorohept-1-yn-4-ol 
• 83447-89-6 3-(4-Chlor-1-butenyl)-2-hydroxy-5-methoxy-1,4-naphthochinon 
• 75782-94-4 6-chloro-3-hexanol 
• 92944-23-5 6-Chloro-2-methyl-hex-1-en-3-ol 
• 100959-06-6 1-chloro-5-methyl-4-hexene 
• 132124-52-8 (Z)-4-Nonenylchlorid 
• 148311-91-5 (Z)-1-Cyclopropyl-1-hexen 
• 84904-89-2 6-aza-1-azoniatricyclo<5.4.2.0^1,8>tridecane chloride 

Relevant articles and documents

Synthesis, biological evaluation, and pharmacophore generation of uracil, 4(3H)-pyrimidinone, and uridine derivatives as potent and selective inhibitors of parainfluenza 1 (Sendai) virus

Several new 6-oxiranyl-, 6-oxiranylmethyluracils, and pyrimidinone derivatives, synthesized by lithiation-alkylation sequence of 1,3,6-trimethyluracil, 1,3-dimethyl-6-chloromethyluracil, and 2-alkoxy-6-methyl-4(3H)-pyrimidinones, showed a potent and selective antiviral activity against Sendai virus (SV) replication. To gain insight into the structural features required for SV inhibition activity, the new compounds were submitted to a pharmacophore generation procedure using the program Catalyst. The resulting pharmacophore model showed high correlation and predictive power. It also rationalized the relationships between structural properties and biological data of these inhibitors of SV replication.

Organocatalytic diastereo- And enantioselective oxa-hetero-Diels-Alder reactions of enones with aryl trifluoromethyl ketones for the synthesis of trifluoromethyl-substituted tetrahydropyrans

Tetrahydropyran derivatives are found in bioactives, and introduction of the trifluoromethyl group into molecules often improves biofunctions. Here we report diastereo- and enantioselective oxa-hetero-Diels-Alder reactions catalyzed by amine-based catalyst systems that afford trifluoromethyl-substituted tetrahydropyranones. Catalyst systems and conditions suitable for the reactions to provide the desired diastereomer products with high enantioselectivities were identified, and various trifluoromethyl-substituted tetrahydropyranones were synthesized with high diastereo- and enantioselectivities. Mechanistic investigation suggested that the reactions involve a [4 + 2] cycloaddition pathway, in which the enamine of the enone acts as the diene and the ketone carbonyl group of the aryl trifluoromethyl ketone acts as the dienophile. In this study, tetrahydropyran derivatives with the desired stereochemistry that are difficult to synthesize by previously reported methods were concisely obtained, and the range of tetrahydropyran derivatives that can be synthesized was expanded. This journal is

NOVEL COMPOUNDS HAVING ESTROGEN RECEPTOR ALPHA DEGRADATION ACTIVITY AND USES THEREOF

The present disclosure relates to novel compounds having estrogen receptor alpha degradation activity, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions.