61419-02-1

Basic information

• Product Name: NAPHTHOFLUORESCEIN
• Synonyms: NAPHTHOFLUORESCEIN;NAPHTHOFLUORESCEIN, FOR FLUORESCENCE;NAPHTHOFLUORESCEIN FOR FLUORESCENCE 95+%;Naphthafluorescein;Spiro[7H-dibenzo[c,h]xanthene-7,1'(3'H)-isobenzofuran]-3'-one,3,11-dihydroxy-
• CAS NO: 61419-02-1
• Molecular Formula: C₂₈H₁₆O₅
• Molecular Weight: 432.429
• EINECS: 257-250-0
• Mol File: 61419-02-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 189 °C (dec.)(lit.)
• Boiling Point: 755.5°C at 760 mmHg
• Flash Point: 266.3°C
• Appearance: /
• Density: 1.58g/cm³
• Vapor Pressure: 1.27E-23mmHg at 25°C
• Refractive Index: 1.86
• Solubility: DMF: soluble
• BRN: 61335
• CAS DataBase Reference: NAPHTHOFLUORESCEIN(CAS DataBase Reference)
• NIST Chemistry Reference: NAPHTHOFLUORESCEIN(61419-02-1)
• EPA Substance Registry System: NAPHTHOFLUORESCEIN(61419-02-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 8-10
• Hazardous Substances Data: 61419-02-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 61419-02-1 differently. You can refer to the following data:
1. Naphtofluorescein is a pH-sensitive fluorescent probe, also used for preparation of labels and enzyme substrates.
2. Naphthofluorescein is a furin inhibitor.

InChI:InChI=1/C28H16O5/c29-17-7-9-19-15(13-17)5-11-23-25(19)32-26-20-10-8-18(30)14-16(20)6-12-24(26)28(23)22-4-2-1-3-21(22)27(31)33-28/h1-14,29-30H

Upstream product

• 100884-30-8 1,6-bis-methoxymethoxy-naphthalene 
• 575-44-0 1,6-dihydroxynaphthalene 
• 85-44-9 phthalic anhydride 
• 7664-93-9 sulfuric acid 
• 397883-28-2 2-(1.6-dihydroxy-[2]naphthoyl)-benzoic acid 

Downstream Products

• 874657-97-3 C₄₂H₂₈O₉S₂ 
• 1380077-15-5 methyl 2-(11-hydroxy-3-oxo-3H-dibenzo[c,h]xanthen-7-yl)benzoate 
• 51517-45-4 3,11-dihydroxy-3′H-spiro[dibenzo[c,h]xanthene-7,1′-isobenzofuran]-3′-one 
• 77084-72-1 3,11-bis-benzoyloxy-spiro[dibenzo[c,h]xanthene-7,1'-phthalan]-3'-one 
• 77084-71-0 3,11-diacetoxy-spiro[dibenzo[c,h]xanthene-7,1'-phthalan]-3'-one 

Relevant articles and documents

A dual-response naphthofluorescein-based fluorescent probe for multiple-channel imaging of cysteine/homocysteine in living cells

A naphthofluorescein-based fluorescent probe with two independent reaction sites (nitro-2,1,3-benzoxadiazole and acrylate moiety) was developed. Integrating these two reaction sites into a single molecule not only can guarantee the selective detection of Cys/Hcy in an elegant fashion, but also can enable Cys/Hcy detection in a multiple-channel responsive manner.

METHOD FOR PRODUCING FLUORESCEIN COMPOUND

To provide a method for producing a high-purity fluorescein compound on an industrial scale efficiently and safely.SOLUTION: A compound having a phenolic hydroxyl group and an acid anhydride are reacted with each other in the presence of an acidic catalyst, to obtain a fluorescein compound. The resultant fluorescein compound is dissolved in an alkaline solvent and then an acid is added thereto, controlling the pH of the solution into the acidic region. After that, an inorganic salt is added thereto, forming crystals. In this way, a fluorescein compound is produced.SELECTED DRAWING: Figure 1

HIGH-PURITY FLUORESCEIN COMPOUND AND MANUFACTURING METHOD THEREOF

PROBLEM TO BE SOLVED: To provide a high-purity fluorescein compound, and to provide a method for producing a high-purity fluorescein compound in an efficient and a highly safe manner on an industrial scale. SOLUTION: A compound having a phenolic hydroxy group and an acid anhydride compound are reacted with a solvent containing a carboxylic acid as a reaction solvent in the presence of an acidic catalyst to obtain a highly pure fluorescein compound represented by formula (1) having a chemical purity of 95% or more. In the formula (1), x, y, and z represent an integer of 0 to 4, and R1, R2, and R3 each independently represents a fused benzene ring having a substituent or an unsubstituted fused benzene ring. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT