61478-25-9Relevant articles and documents
Synthesis, molecular modeling and biological evaluations of novel pyrrolidine derivatives as potential cyclooxygenase-2 (COX-2) inhibitors
Chavan, Kamlesh H.,Kedar, Nathrao Ankushrao,Kanhed, Ashish M.,Agrahari, Vishal Kumar,Sinha, Anshuman
, p. 1801 - 1813 (2021)
Abstract: Toward the development of selective cyclooxygenase-2 inhibitors, a series of pyrrolidine derivatives is described. All the compounds containing sulfonamide, ester, nitrile, acid, amide and urea functionalities were computationally screened, and
Synthesis and biological evaluation of selective and potent cyclin-dependent kinase inhibitors
N'Gompaza-Diarra, Joannah,Bettayeb, Karima,Gresh, Nohad,Meijer, Laurent,Oumata, Nassima
, p. 210 - 216 (2013/01/15)
A new series of 2,6,9-trisubstituted purines, structurally related to the cyclin-dependent kinase (CDK) inhibitor Roscovitine, has been synthesized. These compounds mainly differ by the substituent on the C-2 position which encompasses a diol group. These
Total synthesis of (+)-dibromophakellin and (+)-dibromophakellstatin
Imaoka, Takuya,Akimoto, Takafumi,Iwamoto, Osamu,Nagasawa, Kazuo
scheme or table, p. 1810 - 1816 (2011/04/16)
A new method for the preparation of quaternary chiral aminals has been developed that employs an enamide-type Overman rearrangement process. This methodology was applied to enantioselective total syntheses of (+)-dibromophakellin and (+)-dibromophakellstatin.
