61478-26-0

Basic information

• Product Name: BOC-HYP-OL
• Synonyms: TERT-BUTYL (2S,4R)-4-HYDROXY-2-(HYDROXYMETHYL)PYRROLIDINE-1-CARBOXYLATE;(-)-N-BOC-L-4-HYDROXYPROLINOL;N-BOC-TRANS-4-HYDROXY-L-PROLINOL;N-T-BUTOXYCARBONYL-TRANS-4-HYDROXY-L-PROLINOL;BOC-HYP-OL;BOC-PRO(4-HYDROXY)-OL;BOC-TRANS-4-HYDROXY-L-PROLINOL;1-Pyrrolidinecarboxylic acid, 4-hydroxy-2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S,4R)-
• CAS NO: 61478-26-0
• Molecular Formula: C₁₀H₁₉NO₄
• Molecular Weight: 217.26
• Product Categories: Amino Acid Derivatives;Amino Alcohols;Peptide Synthesis
• Mol File: 61478-26-0.mol

Chemical Properties

• Melting Point: 81-86 °C(lit.)
• Boiling Point: 340.296 °C at 760 mmHg
• Flash Point: 159.605 °C
• Appearance: /
• Density: 1.19 g/cm³
• Refractive Index: 1.511
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.57±0.40(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: BOC-HYP-OL(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-HYP-OL(61478-26-0)
• EPA Substance Registry System: BOC-HYP-OL(61478-26-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 61478-26-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
BOC-HYP-OL is used as a reactant for the preparation of 4-purinylpyrrolidine nucleosides, which are important in the development of new drugs targeting various diseases and conditions. Its unique structure allows for the creation of novel compounds with potential therapeutic applications.
Used in Kinase Inhibitor Development:
BOC-HYP-OL is utilized as a key component in the synthesis of kinase inhibitors, which are crucial in the treatment of various cancers and other diseases. By targeting specific kinases, these inhibitors can help regulate cellular processes and prevent the uncontrolled growth of cancer cells.
Used in Antibacterial Agent Synthesis:
In the field of antibacterial drug development, BOC-HYP-OL serves as a valuable reactant for the creation of new agents that can combat bacterial infections. Its incorporation into the synthesis process allows for the development of more effective and targeted treatments against various bacterial strains.

InChI:InChI=1/C10H19NO4/c1-10(2,3)15-9(14)11-5-8(13)4-7(11)6-12/h7-8,12-13H,4-6H2,1-3H3/t7-,8+/m1/s1

Upstream product

• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 61478-27-1 (2S,4S)-N-(tert-butoxycarbonyl)-4-(p-toluenesulfonyloxy)-2-<(p-toluenesulfonyloxy)methyl>pyrrolidine 
• 194089-91-3 tert-butyl (2S,4R)-4-hydroxy-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)-pyrrolidine-1-carboxylate 
• 194089-94-6 (2S,4S)-4-Diphenylphosphanyl-2-methoxymethyl-pyrrolidine 
• 802911-23-5 (2S,4R)-(N-tert-butyloxycarbonyl)-4-(Z)-propenylproline 
• 364750-80-1 (2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid 
• 540501-56-2 (2S,4S)-tert-butyl 2-(hydroxymethyl)-4-methylpyrrolidine-1-carboxylate 
• 540501-47-1 (2S,4R)-N-tert-butyloxycarbonyl-4-propylproline 
• 540501-62-0 (2S,4S)-N-tert-butyloxycarbonyl-4-propylproline 
• 540501-43-7 (2S,4R)-N-tert-butyloxycarbonyl-4-benzyl-2-hydroxymethylpyrrolidine 
• 540501-37-9 (S)-2-Hydroxymethyl-4-[1-phenyl-meth-(E)-ylidene]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 540501-64-2 (2S,4S)-N-tert-butyloxycarbonyl-4-(methoxycarbonyl)methylproline 
• 540501-64-2 (2S,4R)-N-tert-butyloxycarbonyl-4-(methoxycarbonyl)methylproline 
• 153074-95-4 (2S,4R)-4-benzyl-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid 
• 83623-78-3 (2S,4S)-4-benzyl-N-tert-butyloxycarbonylproline 

Relevant articles and documents

OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION

The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents) and methods for their preparation. The ligands are derived primarily from monosaccharides These conjugates are useful for the in vivo delivery of oligonucleotides.

Substituted Imidazopyridines as HDM2 Inhibitors

The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.

A practical synthesis of (1S,4S)-2,5-diazabicyclo[2.2.1]heptane

The rigid piperazine homologue 2,5-diazabicyclo[2.2.1]heptane (DBH) finds extensive application in medicinal chemistry and pharmaceutical research, but access to this scaffold is non-trivial. This letter details a concise synthetic sequence that gives ready access to DBH on gram scale. The route features a Staudinger reduction of an azide to facilitate a transannular cyclisation.

Synthesis of (1S,4S)-2-Thia-5-azabicycloheptane

Starting from trans-4-hydroxy-L-proline, (1S,4S)-2-thia-5-azabicycloheptane (1) has been synthesised via the key intermediate N-(t-butoxycarbonyl)-trans-4-hydroxy-L-prolinol ditosylate (7).