615-15-6Relevant articles and documents
Synthesis, structures, and luminescence of two 2-D microporous metal-organic frameworks in the zinc (cadmium)-dicarboxylate-imidazolate system
Guo, Xiaoqing,Wang, Miao,Gu, Xuefang,Zhu, Jinli,Tang, Yanfeng,Jiang, Guoqing,Bai, Junfeng
, p. 1819 - 1827 (2016)
Two 2-D microporous metal–organic frameworks, [Zn(BDC)(MbIm)]·2DMF (1) and [Cd3(BDC)3(MbIm)2(DMF)2]·2DMF (2), have been synthesized by solvothermal reaction of 1,4-benzenecarboxylic acid (H2BDC) and 2-methylbenzimidazole (MbIm) with zinc/cadmium nitrate. Single-crystal X-ray diffraction analysis indicates that 1 consists of the well-known zinc paddle-wheel motif which is linked by bridging dicarboxylates to form 2-D square grids. The 2-D layers stack offset due to the effect of the spatial structure of MbIm ligand and hydrogen-bonding interaction between MbIm and guest molecules. Similarly, 2 is constructed by six-connected Cd3(μ-O2CR)6(MbIm)2 units and bridging carboxylates, resulting in a 2-D layer structure with triangular grids. Topology analysis reveals that 1 exhibits a 2-D tetragonal plane network with {44·62} topology symbol, while 2 possesses a six-connected {36·46·53} topological network. Analysis of the luminescence spectra demonstrates that the complexes have good luminescent intensities with greater red-shift (82 nm for 1 and 69 nm for 2) corresponding to free MbIm. Elemental analyses, infrared spectra, powder X-ray diffraction, and thermogravimetric analyses of 1 and 2 have been investigated.
Synthesis, crystal structure, and thermal stability of [Mo 2O4(μ2-O)(C6H4O 2)2(H2O)]·(C8H 9N2)2·2H2O
Xu
, p. 48 - 53 (2014)
From hydrothermal treatment of benzene-1,2-diamine, pyrocatechol, and MoO3 in acetic acid solution, a new compound, [Mo2(μ 2-O)2(C6H4O2) 2(H2O)]·(C8H9N 2)2·2H2O (I), constructed from pyrocatechol chelated dinuclear molybdenum units and 2-methylbenzimidazole has been synthesized. Single-crystal structure analysis reveals that the compound crystallizes in the monoclinic space group P21/c with a = 23.365(2), b = 7.2214(5), c = 19.3021(16) β = 97.929(4), V = 3225.6(5), Z = 4, M = 808.46, ρc = 1.665 g/cm3, μ(MoK α) = 0.84 mm-1, F(000) = 1608, the final R = 0.0622 and wR = 0.1484 for 7385 independent reflections with R int = 0.0393. Interestingly, an in situ condensation between acetic acid and benzene-1,2-diamine has occurred, and the unexpected 2-methyl-1-H-benzo[d] imidazoles serve as counterions and N-H donors to form stable hydrogen-bond network in the crystal. Furthermore, intermolecular hydrogen bonds are found among the cations, anions and crystalline water molecules. The double nuclear molybdenum units are connected by O-H.O hydrogen bonds with the crystalline water molecules to form one-dimensional chains, and the chains are further joined together by N-H.O to form a quasi-two dimensional structure.
Electroanalytical and computational studies on the corrosion inhibition behavior of ethyl (2-methylbenzimidazolyl) acetate (EMBA) on mild steel in hydrochloric acid
Joseph, Abraham,Mohan, Revathi
, p. 4795 - 4823 (2015)
The interaction and corrosion protection properties of ethyl (2-methylbenzimidazolyl) acetate (EMBA) on mild steel in hydrochloric acid (0.5, 1 and 1.5 M) at different temperatures have been studied by polarization, EIS, adsorption, surface studies, and computational calculations. Polarization studies showed that this molecule act as mixed-type inhibitor. EMBA acts as an effective inhibitor for mild steel in hydrochloric acid at different temperatures (303, 308, and 313 K). At room temperature, EMBA was found to be a more effective inhibitor and its efficiency decreases with increasing temperature. The mechanism involves adsorption of inhibitor molecules on the metal surface and this process obeys the Langmuir isotherm.
Enhanced Catalytic Properties of Carbon supported Zirconia and Sulfated Zirconia for the Green Synthesis of Benzodiazepines
Godino-Ojer, Marina,Milla-Diez, Leticia,Matos, Inês,Durán-Valle, Carlos J.,Bernardo, Maria,Fonseca, Isabel M.,Pérez Mayoral, Elena
, p. 5215 - 5223 (2018)
This work reports for the first time a new series of promising porous catalytic carbon materials, functionalized with Lewis and Br?nsted acid sites useful in the green synthesis of 2,3-dihydro-1H-1,5-benzodiazepine – nitrogen heterocyclic compounds. Benzodiazepines and derivatives are fine chemicals exhibiting interesting therapeutic properties. Carbon materials have been barely investigated in the synthesis of this type of compounds. Two commercial carbon materials were selected exhibiting different textural properties: i) Norit RX3 (N) as microporous sample and ii) mesoporous xerogel (X), both used as supports of ZrO2 (Zr) and ZrO2/SO42? (SZr). The supported SZr led to higher conversion values and selectivities to the target benzodiazepine. Both chemical and textural properties influenced significantly the catalytic performance. Particularly relevant are the results concerning the non-sulfated samples, NZr and XZr, that were able to catalyze the reaction leading to the target benzodiazepine with high selectivity (up to 80 %; 2 h). These results indicated an important role of the carbon own surface functional groups, avoiding the use of H2SO4. Even very low amounts of SZr supported on carbon reveal high activity and selectivity. Therefore, the carbon materials herein reported can be considered an efficient and sustainable alternative bifunctional catalysts for the benzodiazepine synthesis.
Discovery of amide-functionalized benzimidazolium salts as potent α-glucosidase inhibitors
Ahmad, Matloob,Ashfaq, Usman Ali,Khan, Imran Ahmad,Sultan, Sadia,Zaki, Magdi E. A.
, (2021/08/16)
α-Glucosidase inhibitors (AGIs) are used as medicines for the treatment of diabetes mellitus. The α-Glucosidase enzyme is present in the small intestine and is responsible for the breakdown of carbohydrates into sugars. The process results in an increase in blood sugar levels. AGIs slow down the digestion of carbohydrates that is helpful in controlling the sugar levels in the blood after meals. Among heterocyclic compounds, benzimidazole moiety is recognized as a potent bioactive scaffold for its wide range of biologically active derivatives. The aim of this study is to explore the α-glucosidase inhibition ability of benzimidazolium salts. In this study, two novel series of benzimidazolium salts, i.e., 1-benzyl-3-{2-(substituted) amino-2-oxoethyl}-1H-benzo[d]imidazol-3-ium bromide 9a–m and 1-benzyl-3-{2-substituted) amino-2-oxoethyl}-2-methyl-1H-benzo[d] imidazol-3-ium bromide 10a–m were screened for their in vitro α-glucosidase inhibitory potential. These compounds were synthesized through a multistep procedure and were characterized by1H-NMR,13C-NMR, and EI-MS techniques. Compound 10d was identified as the potent α-glucosidase inhibitor among the series with an IC50 value of 14 ± 0.013 μM, which is 4-fold higher than the standard drug, acarbose. In addition, compounds 10a, 10e, 10h, 10g, 10k, 10l, and 10m also exhibited pronounced potential for α-glucosidase inhibition with IC50 value ranging from 15 ± 0.037 to 32.27 ± 0.050 μM when compared with the reference drug acarbose (IC50 = 58.8 ± 0.12 μM). A molecular docking study was performed to rationalize the binding interactions of potent inhibitors with the active site of the α-glucosidase enzyme.
Cobalt ferrite magnetic nanoparticles as highly efficient catalyst for the mechanochemical synthesis of 2-aryl benzimidazoles
Borade, Ravikumar M.,Jadhav, K. M.,Kale, Swati B.,Pawar, Rajendra P.,Tekale, Sunil U.
, (2021/08/27)
A highly efficient magnetically separable nano cobalt ferrite catalyst was synthesized via the sol-gel auto combustion method, characterized by powder XRD, SEM, TEM, UV–Visible, FT-IR, magnetic study, and BET isotherm analysis. The synthesized material was found to be an efficient heterogeneous Lewis acid catalyst for the synthesis of 2-aryl benzimidazole derivatives via solvent-free mechanochemical synthesis. The notable features of this new protocol include solvent-free reaction, cost-effectiveness, good yields, and environmental friendliness to afford the products within a short reaction time along with easy recovery and reuse of the nano catalyst.
