616-27-3

Basic information

• Product Name: 1-CHLOROBUTANONE
• Synonyms: 1-CHLOROBUTANONE;1-CL-MEK;1-chlorobutan-2-one;1-Chlorobutane-2-one;2-Butanone, 1-chloro-
• CAS NO: 616-27-3
• Molecular Formula: C₄H₇ClO
• Molecular Weight: 106.55
• EINECS: 210-473-7
• Mol File: 616-27-3.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 118.37°C (rough estimate)
• Flash Point: 41.7°C
• Appearance: /
• Density: 1.0850
• Vapor Pressure: 7.12mmHg at 25°C
• Refractive Index: 1.4372 (estimate)
• CAS DataBase Reference: 1-CHLOROBUTANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLOROBUTANONE(616-27-3)
• EPA Substance Registry System: 1-CHLOROBUTANONE(616-27-3)

Safety Data

• Hazardous Substances Data: 616-27-3(Hazardous Substances Data)

Usage

General Description

1-Chlorobutanone, also known as 3-chloro-2-butanone or chloroacetone, is an organic compound that belongs to the family of ketones. It is a colorless to pale yellow liquid with a pungent odor and is commonly used as a chemical intermediate or reagent in organic synthesis. 1-Chlorobutanone is a highly reactive compound and is considered to be a strong electrophile, making it useful in various synthetic reactions. However, it is also toxic and can cause irritation to the skin, eyes, and respiratory system, and therefore should be handled with caution. Due to its reactivity and potential health hazards, 1-chlorobutanone is regulated and its use is restricted in some jurisdictions.

InChI:InChI=1/C4H7ClO/c1-2-4(6)3-5/h2-3H2,1H3

Upstream product

• 23010-02-8 2-(chloromethyl)-1-butene 
• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 
• 925-90-6 ethylmagnesium bromide 
• 26189-59-3 1-chloro-1-(dimethylamino)-2-methyl-1-propene 
• 5077-67-8 1-Hydroxy-2-butanone 
• 1873-25-2 1-chloro-butan-2-ol 
• 106-98-9 1-butylene 
• 13898-47-0 hypochloric acid 
• 7782-50-5 chlorine 
• 78-93-3 butanone 
• 3135-74-8 chlorourea 
• 7732-18-5 water 
• 107-02-8 acrolein 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 513-86-0 3-hydroxy-2-butanon 
• 5077-67-8 1-Hydroxy-2-butanone 
• 478813-64-8 7-ethyl-2-phenylimidazo[1,2-a][1,3,5]triazin-4-ylamine 
• 24836-98-4 2-(2-oxobutyl)-1,3-cyclohexanedione 
• 31061-24-2 2-(2,4-dioxo-1,3-thiazolidin-3-yl)acetic acid 
• 32272-48-3 4-ethyl-2-methylthiazole 
• 1373941-48-0 1-(4-benzoylpiperazine-1-yl)butane-2-one 
• 1208400-67-2 6-(3,5-dimethoxyphenyl)-3-ethyl-4H-furo[3,2-c]pyran-4-one 
• 79-31-2 isobutyric Acid 
• 79-11-8 chloroacetic acid 
• 64975-72-0 (-)-(R)-(phenyl)(phenylmethoxycarbonylamino)acetic acid 2-oxo-butyl ester 
• 161268-30-0 1-phenoxy-2-butanone 
• 73622-75-0 1-(4-Methoxyacetyl-1-naphthoxy)-butanon-(2) 
• 94866-78-1 1-(4-Benzoyl-1-naphthoxy)-butanon-⁽²⁾ 

Relevant articles and documents

A mild method for conversion of epoxides into α-chloro ketones

Epoxides on treatment with DMSO, oxalyl chloride, and 10 mole % of methanol in the presence of triethylamine at -60°C are converted to α-chloro ketones in high yield.

A mild method for the replacement of a hydroxyl group by halogen. 1. Scope and chemoselectivity

α-Chloro-, bromo- and iodoenamines, which are readily prepared from the corresponding isobutyramides have been found to be excellent reagents for the transformation of a wide variety of alcohols or carboxylic acids into the corresponding halides. Yields are high and conditions are very mild thus allowing for the presence of sensitive functional groups. The reagents can be easily tuned allowing therefore the selective monohalogenation of polyhydroxylated molecules. The scope and chemoselectivity of the reactions have been studied and reaction mechanisms have been proposed.

Method for preparing chiral diphosphines

The invention concerns a method for preparing a compound of formula (1) wherein: A represents naphthyl or phenyl optionally substituted; and Ar1, Ar2independently represent a saturated or aromatic carbocyclic group, optionally substituted.