61690-45-7

Basic information

• Product Name: Hydrazine, (4-methoxy-2-nitrophenyl)-
• CAS NO: 61690-45-7
• Molecular Formula: C7H9N3O3
• Molecular Weight: 183.16500
• Mol File: 61690-45-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Hydrazine, (4-methoxy-2-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazine, (4-methoxy-2-nitrophenyl)-(61690-45-7)
• EPA Substance Registry System: Hydrazine, (4-methoxy-2-nitrophenyl)-(61690-45-7)

Safety Data

• Hazardous Substances Data: 61690-45-7(Hazardous Substances Data)

Upstream product

• 96-96-8 4-methoxy-2-nitroaniline 

Downstream Products

• 1335246-72-4 5-hydroxy-3-methyl-7-nitro-2-phenylindole 
• 1352196-37-2 3-methyl-5-methoxy-7-nitro-2-phenylindole 
• 13838-45-4 5-methoxy-7-nitro-1H-indole-2-carboxylic acid 
• 1000341-42-3 5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester 
• 271786-56-2 1-(4-methoxy-2-nitro-phenyl)-4,4-dimethyl-pyrazolidin-3-one 
• 185507-85-1 4-{4-[(4-Methoxy-2-nitro-phenyl)-hydrazono]-piperidin-1-yl}-1-phenyl-butan-1-one 
• 185507-83-9 1-(4-Fluoro-phenyl)-4-{4-[(4-methoxy-2-nitro-phenyl)-hydrazono]-piperidin-1-yl}-butan-1-one 
• 159678-66-7 N-acetyl-4-methoxy-2-nitrophenylhydrazine 
• 94830-00-9 2-{4-[(4-Methoxy-2-nitro-phenyl)-hydrazono]-butyl}-isoindole-1,3-dione 

Relevant articles and documents

Structure-based design and biological evaluation of novel 2-(indol-2-yl) thiazole derivatives as xanthine oxidase inhibitors

Inhibition of xanthine oxidase (XO) has obviously been a central concept for controlling hyperuricemia, which causes serious and painful inflammatory arthritis disease such as gout. We discovered a series of novel 2-(indol-2-yl)thiazole derivatives as XO inhibitors at the level of nanomolar activity. Structure-guided design using molecular modeling program (Accelrys Software program) provided an excellent basis for optimization of 2-(indol-2-yl)thiazole compounds. Structure-activity relationship indicated that hydrophobic alkoxy group (isopropoxy, cyclopentoxy) at 5-position and hydrogen binding acceptor (NO2, CN) at 7-position of indole ring appear as critical functional groups. Among the compounds, 2-(7-nitro-5-isopropoxy-indol-2-yl)-4-methylthiazole-5-carboxylic acid (9m) exhibits the most potent XO inhibitory activity (IC50value: 5.1 nM) and the excellent uric acid lowering activity in potassium oxonate induced hyperuricemic rat model.

Fungicidal activity of some o-nitrophenyl-hydrazones

The antimycotic activity of 16 o-nitrophenylhydrazones against strains of Hansenula anomala, Saccharomyces cerevisiae, Candida parapsylosis, and Cryptococcus albidus was tested. All 16 compounds inhibited growth of the yeast strains. The inhibitory activity of the 4 methyl-derivatives substituted on the aromatic nucleus was particularly significant.