618-40-6

Basic information

• Product Name: 1-Methyl-1-phenylhydrazine
• Synonyms: N-METHYL-N-PHENYLHYDRAZINE;1-Methyl-1-PhenylhydrazineHydrochloride;1-Methyl-1-PhenylhydrazineHcl;α-Methylphenylhydrazine, N-Methyl-N-phenylhydrazine;1-Methyl-1-phenylhydrazine,96%;1-Methyl-1-phenylhydrazine,98%;1-Methyl-1-phenylhydrazine,α-Methylphenylhydrazine, N-Methyl-N-phenylhydrazine;1-Methyl-1-phenylhydrazine, 96% 5GR
• CAS NO: 618-40-6
• Molecular Formula: C₇H₁₀N₂
• Molecular Weight: 122.17
• EINECS: 210-547-9
• Product Categories: Building Blocks;Chemical Synthesis;Hydrazines;Nitrogen Compounds;Organic Building Blocks
• Mol File: 618-40-6.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 54-55 °C0.3 mm Hg(lit.)
• Flash Point: 205 °F
• Appearance: Clear yellow to orange-brown/Liquid
• Density: 1.038 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0324mmHg at 25°C
• Refractive Index: n20/D 1.583(lit.)
• Storage Temp.: 0-6°C
• PKA: 5.37±0.10(Predicted)
• Water Solubility: Slightly soluble
• BRN: 507683
• CAS DataBase Reference: 1-Methyl-1-phenylhydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1-phenylhydrazine(618-40-6)
• EPA Substance Registry System: 1-Methyl-1-phenylhydrazine(618-40-6)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-45
• RIDADR: 2810
• WGK Germany: 3
• RTECS: MV7712000
• F: 8-10-23
• TSCA: Yes
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 618-40-6(Hazardous Substances Data)

Usage

Uses

1-Methyl-1-phenylhydrazine is used to make other chemicals.

InChI:InChI=1/C7H10N2/c1-9(8)7-5-3-2-4-6-7/h2-6H,8H2,1H3

Upstream product

• 614-00-6 N-methyl-N-nitrosoaniline 
• 64-19-7 acetic acid 
• 74-83-9 methyl bromide 
• 100-63-0 phenylhydrazine 
• 38604-68-1 N'-methyl-N'-phenylacetohydrazide 
• 60-80-0 antipyrine 
• 7803-57-8 hydrazine hydrate 
• 110811-17-1 1-(p-(dimethylamino)phenyl)-3-methyl-3-phenyl-triazene-1-oxide 
• 106087-08-5 3-amino-1-methyl-1-phenyl-4,5-dihydropyrazol-1-ium iodide 
• 4559-87-9 1-methyl-1-phenylurea 
• 17881-80-0 (2-picolyl)trimethylsilane 
• 2989-45-9 1-benzylidene-2-methyl-2-phenylhydrazine 
• 74-88-4 methyl iodide 
• 127-09-3 sodium acetate 

Downstream Products

• 77305-84-1 Isatin methylphenylhydrazone 
• 38604-68-1 N'-methyl-N'-phenylacetohydrazide 
• 66706-33-0 N-methyl-N-phenyl-N'-picryl-hydrazine 
• 66202-77-5 1-methyl-1,4-diphenyl thiosemicarbazide 
• 42108-36-1 propionic acid-(N'-methyl-N'-phenyl-hydrazide) 
• 13831-36-2 N-methyl-N-phenyl-benzamidrazone 
• 7400-38-6 2,5-Dimethyl-N-N'-methyl-anilino-pyrrol 
• 3265-26-7 2-(methyl-phenyl-hydrazono)-propionic acid 
• 13750-26-0 C₁₅H₁₇N₃O₃S 
• 5327-21-9 N'-Methyl-N'-phenyl-hydrazinecarboxylic acid isopropyl ester 
• 5311-80-8 1-methyl-1-phenyl-2-propylidenehydrazine 
• 67134-56-9 2-benzyl-1-methyl-3-phenyl-1H-indole 
• 857808-69-6 2-(2-anilino-phenyl)-2-methyl-1-phenyl-propan-1-one 
• 99813-92-0 D-arabino-[2]hexosulose 1-(methyl-phenyl-hydrazone) 

Relevant articles and documents

-

-

Rh(iii)-catalyzed, hydrazine-directed C-H functionalization with 1-alkynylcyclobutanols: A new strategy for 1: H -indazoles

Rh(iii)-catalyzed coupling of phenylhydrazines with 1-alkynylcyclobutanols was realized through a hydrazine-directed C-H functionalization pathway. This [4+1] annulation, based on the cleavage of a Csp-Csp triple bond in alkynylcyclobutanol, provides a new pathway to prepare diverse 1H-indazoles under mild reaction conditions. This journal is

A Versatile, Traceless C-H Activation-Based Approach for the Synthesis of Heterocycles

A versatile, traceless C-H activation-based approach for the synthesis of diversified heterocycles is reported. Rh(III)-catalyzed, N-amino-directed C-H alkenylation generates either olefination products or indoles (in situ annulation) in an atom- and step-economic manner at room temperature. The remarkable reactivity endowed by this directing group enables scale-up of the reaction to a 10 g scale at a very low catalyst loading (0.01 mol %/0.1 mol %). Ex situ annulation of olefination product provides entry into an array of heterocycles.