620-81-5Relevant articles and documents
Tuning the Reactivity of Cofacial Porphyrin Prisms for Oxygen Reduction Using Modular Building Blocks
Crawley, Matthew R.,Zhang, Daoyang,Oldacre, Amanda N.,Beavers, Christine M.,Friedman, Alan E.,Cook, Timothy R.
supporting information, p. 1098 - 1106 (2021/02/03)
We assembled eight cofacial porphyrin prisms using MTPyP (M = Co(II) or Zn(II), TPyP = 4-tetrapyridylporphyrin) and functionalized ruthenium-based "molecular clips"using coordination-driven self-assembly. Our approach allows for the rapid synthesis of these architectures in isolated yields as high as 98% for the assembly step. Structural and reactivity studies provided a deeper understanding of the role of the building blocks on the oxygen reduction reaction (ORR). Catalytic efficacy was probed by using cyclic and hydrodynamic voltammetry on heterogeneous catalyst inks in aqueous media. The reported prisms showed outstanding selectivity (>98%) for the kinetically hindered 4e-/4H+ reduction of O2 to H2O over the kinetically more accessible 2e-/2H+ reduction to H2O2. Furthermore, we have demonstrated significant cofacial enhancement in the observed catalytic rate constant ks (μ5 orders of magnitude) over the mononuclear analogue. We conclude that the steric bulk of the clip plays an important role in the structural dynamics of these prisms, which in turn modulates the ORR reactivity with respect to selectivity and kinetics.
Visible-light-induced direct construction of amide bond from carboxylic acids with amines in aqueous solution
Wang, Jin,Hou, Huiqing,Hu, Yongzhi,Lin, Jin,Wu, Min,Zheng, Zhiqiang,Xu, Xiuzhi
supporting information, (2021/02/09)
A novel visible-light-promoted N-acylation for the synthesis of amides from easily available carboxylic acids with amines in the presence of I2 within 2.5 h in aqueous solution has been developed. Using sunlight as the visible light source greatly reduces the cost of experiments and produces almost no toxic effects. Hence, this study provides an alternative catalytic system for the construction of a wide range of amides with readily available materials. Moreover, the strategy was successfully applied in the preparation of N-(3-(2,6-dimethoxyphenoxy)-7-nitroquinoxalin-2-yl)benzohydrazide, which displayed a signification anti-proliferation effect on A549, MCF-7 and HCT116 cell lines.
Preparation method of oxamide
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Paragraph 0062; 0063; 0070; 0071; 0088, (2019/08/03)
The invention provides a preparation method of oxamide. The preparation method comprises the following steps: an intermediate oxamide derivative is prepared from CO, O2 and amine compounds as raw materials by oxidation and carbonylation under the action of a catalyst 1, and then, oxamide is prepared through aminolysis of the oxamide derivative under the action of a catalyst 2. A novel method is used for coproducing oxamide and the oxamide derivative, and the problems that oxalate synthesis materials are poisonous, catalyst efficiency is low and the like in the original technology for synthesizing oxamide through aminolysis of oxalate are solved. Besides, the technologically synthesized oxamide derivative has good substrate applicability and can be applied to fields of medicine, pesticides,synthetic ligands, food additives and the like.