622369-38-4

Basic information

• Product Name: 7-FLUORO-6-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBONITRILE
• Synonyms: 7-FLUORO-6-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBONITRILE;7-FLUORO-1,4-DIHYDRO-6-METHOXY-4-OXO-3-QUINOLINE;7-Fluoro-6-methoxy-4-oxo-1,4-dihydro-3-quinolinecarbonitrile;3-Quinolinecarbonitrile, 7-fluoro-1,4-dihydro-6-Methoxy-4-oxo-;7-fluoro-6-methoxy-4-oxo-1H-quinoline-3-carbonitrile
• CAS NO: 622369-38-4
• Molecular Formula: C₁₁H₇FN₂O₂
• Molecular Weight: 218.1838832
• Mol File: 622369-38-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 362.703 °C at 760 mmHg
• Flash Point: 173.157 °C
• Appearance: /
• Density: 1.40
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.599
• PKA: 2.26±0.50(Predicted)
• CAS DataBase Reference: 7-FLUORO-6-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-FLUORO-6-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBONITRILE(622369-38-4)
• EPA Substance Registry System: 7-FLUORO-6-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBONITRILE(622369-38-4)

Safety Data

• Hazardous Substances Data: 622369-38-4(Hazardous Substances Data)

Usage

General Description

7-Fluoro-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile is a chemical compound with the molecular formula C14H9FN2O2. It is a quinoline derivative with a fluorine atom, a methoxy group, a carbonyl group, and a cyano group attached to the quinoline ring. 7-Fluoro-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile has potential applications in pharmaceutical research, as quinoline derivatives have been studied for their various biological activities, including anti-cancer, anti-inflammatory, and antimicrobial properties. Additionally, the presence of the fluoro and methoxy groups in this compound could potentially impact its pharmacological properties, making it a molecule of interest for further investigation.

InChI:InChI=1/C11H7FN2O2/c1-16-10-2-7-9(3-8(10)12)14-5-6(4-13)11(7)15/h2-3,5H,1H3,(H,14,15)

Upstream product

• 366-99-4 3-fluoro-4-methoxyaniline 
• 94-05-3 ethyl (ethoxymethylene)cyanoacetate 
• 622369-37-3 7-fluoro-6-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxamide 

Downstream Products

• 622369-40-8 4-chloro-6-methoxy-7-fluoro-quinoline-3-carbonitrile 
• 622369-51-1 6-benzyloxy-4-chloro-7-fluoro-3-quinolinecarbonitrile 
• 622368-90-5 4-(2,4-dichloro-5-methoxy-phenylamino)-6-methoxy-7-(1-methyl-piperidin-3-ylmethoxy)-quinoline-3-carbonitrile 
• 622369-26-0 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[(1-methylpiperidine-2-yl)methoxy]quinoline-3-carbonitrile 
• 681819-23-8 4-[(2,4-dichloro-5-ethoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 
• 622369-54-4 7-fluoro-6-methoxy-4-[(3,4,5-trimethoxyphenyl)amino]-3-quinolinecarbonitrile 
• 622369-46-4 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 
• 622369-76-0 4-[(2,4-dimethyl-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 
• 622369-75-9 4-[(2,4-dichlorophenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 
• 622369-78-2 7-fluoro-6-methoxy-4-[(5-methoxy-2-methylphenyl)amino]-3-quinolinecarbonitrile 
• 622369-79-3 4-[(2,4-dimethylphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 
• 622369-21-5 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-methylpiperidin-4-yl)propoxy]quinoline-3-carbonitrile 
• 622368-88-1 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[2-(1-methylpiperidin-4-yl)ethoxy]-3-quinolinecarbonitrile 
• 380843-75-4 bosutinib 

Relevant articles and documents

A practical synthesis of 7-(3-chloropropoxy)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile, a key intermediate to bosutinib

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4-ANILINO-3-QUINOLINECARBONITRILES FOR THE TREATMENT OF CHRONIC MYELOGENOUS LEUKEMIA (CML)

Compounds of the formula (I): wherein: n is an integer from 0-3; X is N, CH; R is alkyl of 1 to 3 carbon atoms; R' is 2,4-diCl, 5-OMe in para, ortho, or meta position; 2,4-diCl in para position; 3,4,5-tri-OMe in para position; 2-Cl, 5-OMe in para position

Process for the preparation of 7-substituted-3 quinolinecarbonitriles

There is provided a process for the preparation of 7-substituted-3-quinolinecarbonitriles and intermediates useful in a process to prepare 7-substituted-3-quinolinecarbonitriles and pharmaceutically acceptable salts is described. Where 7-fluoro-4-oxo-1,4-