62252-26-0 Usage
Uses
JLK 6 is an inhibitor of γ-secretase, selectively inhibits βAPP cleavage.
Biological Activity
Inhibitor of γ -secretase that selectively inhibits β APP cleavage without affecting other γ -secretase-mediated pathways. Prevents recovery of A β 40 and A β 42 from HEK293 cell overexpressing wild-type or Swedish-mutated β APP (IC 50 ~ 30 μ M) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α -secretase, the proteosome or GSK3 β .
references
[1]. petit a, pasini a, alves da costa c, et al. jlk isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo. journal of neuroscience research, 2003, 74(3): 370-377.[2]. petit a, bihel f, da costa ca, et al. new protease inhibitors prevent γ-secretase-mediated production of aβ40/42 without affecting notch cleavage. nature cell biology, 2001, 3(5): 507-511.
Check Digit Verification of cas no
The CAS Registry Mumber 62252-26-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,2,5 and 2 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 62252-26:
(7*6)+(6*2)+(5*2)+(4*5)+(3*2)+(2*2)+(1*6)=100
100 % 10 = 0
So 62252-26-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H8ClNO3/c1-14-10-8(11)6-3-2-5(12)4-7(6)9(13)15-10/h2-4H,12H2,1H3
62252-26-0Relevant articles and documents
Alkyne derivatives of isocoumarins as clickable activity-based probes for serine proteases
Haedke, Ute,G?tz, Markus,Baer, Philipp,Verhelst, Steven H.L.
, p. 633 - 640 (2012/03/11)
Activity-based probes (ABPs) have found increasing use in functional proteomics studies. Recently, ABPs that can be employed in combination with click chemistry gained particular attention due to their flexible application in vitro and in vivo. Moreover,
Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new β-amyloid peptide production inhibitors and their activities on various classes of protease
Bihel, Frederic,Quelever, Gilles,Lelouard, Hugues,Petit, Agnes,Da Costa, Cristine Alves,Pourquie, Olivier,Checler, Frederic,Thellend, Annie,Pierre, Philippe,Kraus, Jean-Louis
, p. 3141 - 3152 (2007/10/03)
A series of new 7-substituted-4-chloro-3-alkoxy isocoumarin derivatives were synthesized and evaluated as inhibitors of representative classes of proteases: serine protease (α-chymotrypsin, trypsin), cysteine protease (Caspase-3), and aspartyl protease (H
