6228-73-5

Basic information

• Product Name: CYCLOPROPANECARBOXAMIDE
• Synonyms: TIMTEC-BB SBB008326;CYCLOPROPANECARBOXAMIDE;CYCLOPROPYL CARBOXYAMIDE;CYCLOPROPYLCARBOXAMIDE;Arcado;Seed One;trans-2,2-dichloro-N-(1-(4-chlorophenyl)ethyl)-1-ethyl-3-methylcyclopropanecarboxamide;Win
• CAS NO: 6228-73-5
• Molecular Formula: C₄H₇NO
• Molecular Weight: 85.1
• EINECS: 228-332-3
• Product Categories: Cyclopropanes;Simple 3-Membered Ring Compounds;Fine Chemical
• Mol File: 6228-73-5.mol
• Article Data: 19

Chemical Properties

• Melting Point: 120-122°C
• Boiling Point: 248.5 °C at 760 mmHg
• Flash Point: 104.1 °C
• Appearance: light brown crystalline powder
• Density: 1.187 g/cm³
• Vapor Pressure: 0.0242mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 16.60±0.20(Predicted)
• Water Solubility: Insoluble in water.
• BRN: 1924346
• CAS DataBase Reference: CYCLOPROPANECARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOPROPANECARBOXAMIDE(6228-73-5)
• EPA Substance Registry System: CYCLOPROPANECARBOXAMIDE(6228-73-5)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 22-24/25
• TSCA: Yes
• Hazardous Substances Data: 6228-73-5(Hazardous Substances Data)

Usage

Uses

Cyclopropanecarboxamide is used in the preparation of 2-(cyclopropanecarbonyl-amino)-but-2-enoic acid by reacting with 2-oxo-butyric acid.

InChI:InChI=1/C4H7NO/c5-4(6)3-1-2-3/h3H,1-2H2,(H2,5,6)

Upstream product

• 628-20-6 4-Chlorobutyronitrile 
• 141-52-6 sodium ethanolate 
• 63190-44-3 cyclopropanecarboximidic Acid Ethyl Ester Hydrochloride 
• 5500-21-0 cyclopropropanecarbonitrile 
• 765-43-5 Cyclopropyl methyl ketone 
• 64969-79-5 cyclopropanecarboxylic acid isobutyl ester 
• 1759-53-1 cyclopropanecarboxylic acid 
• 4023-34-1 cyclopropanecarboxylic acid chloride 
• 99912-18-2 2,3,4,5,-Tetrahydro-11-phenyl-1H-[1,4]diazepino[1,7-a]indole 

Downstream Products

• 10528-56-0 bis-cyclopropanecarbonyl-amine 
• 672286-27-0 methyl 3-(cyclopropanecarboxamido)benzoate 
• 477498-68-3 N-[2-(benzo[d]oxazol-2-yl)phenyl]cyclopropanecarboxamide 
• 7108-41-0 cyclopropanecarboxylic acid p-tolylamide 
• 1365989-41-8 N-(2-(2-chloro-6-fluorophenyl)thiazolo[5,4-c]pyridin-4-yl)cyclopropanecarboxamide 
• 1365989-28-1 N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)cyclopropanecarboxamide 
• 1365989-52-1 N-(2-(2,6-dichlorophenyl)thiazolo[4,5-d]pyrimidin-7-yl)cyclopropanecarboxamide 
• 1268091-42-4 4-(chloromethyl)-2-cyclopropyloxazole 
• 1353576-27-8 N-(5-chloro-3-(2-cyclopropyl-5-(2-(methylthio)pyrimidin-4-yl)oxazol-4-yl)-2-fluorophenyl)pivalamide 
• 1345847-93-9 N-(4-(2-(cyclopropanecarboxamido)pyridin-4-yloxy)-2,5-difluorophenyl)-N’-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1334407-16-7 N-(2-(2,6-dichloro-4-cyanophenyl)-3H-imidazo[4,5-c]pyridin-4-yl)cyclopropanecarboxamide 
• 1334407-23-6 N-(2-(2,6-dichlorophenyl)-7-fluoro-1H-imidazo[4,5-c]pyridin-4-yl)cyclopropanecarboxamide 
• 1334407-21-4 N-(8-(2,6-dichlorophenyl)-7H-purin-6-yl)cyclopropanecarboxamide 
• 1258298-19-9 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)-4-vinylbenzamide 

Relevant articles and documents

Novel method and technology for synthesizing cyclopropyl ammonia

The invention discloses a synthesis process route of a cyclopropane synthetic route. In the process route, cyanocyclopropane 1 - formic acid (-1 -) and (1) are subjected to hydrolysis under the action of a strong base to generate 1-cyanocyclopropane 1 - formic acid (-1 -), (2) decarboxylation to generate cyclopropanecarboxamide (2 3), and (4 4 3) subjected to Hoffman rearrangement to obtain the target product cyclopropysite. The process route is longer than the production process in the present stage, the reaction route is long, the use of high-temperature and high-pressure is avoided, the danger is reduced, and the safety is improved. The requirement of the reaction equipment is reduced, the used raw materials are easy to obtain, operation is easy, safety and environmental protection are achieved, and industrial production can be realized.

Efficient Hydration of Nitriles Promoted by Gallic Acid Derived from Renewable Bioresources

An efficient gallic acid promoted nitriles hydration at room temperature with ethanol/water as a solvent has been developed. The present protocol offers a wide range of amides in moderate to good yields. Moreover, galla chinensis extract can serve as the promoter to perform the hydration, which also shows the potential utilization of natural feedstocks.

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.