623559-48-8Relevant articles and documents
Synthesis and bioevaluation of glycosyl ureas as α-glucosidase inhibitors and their effect on mycobacterium
Tewari, Neetu,Tiwari,Mishra,Tripathi,Srivastava,Ahmad,Srivastava,Srivastava
, p. 2911 - 2922 (2007/10/03)
Glycosyl amino esters (2-13) on reaction with different isocyanates resulted in quantitative conversion to glycosyl ureas (14 - 32). Few of the selected ureas (15-20, 22-28, 30 and 32) on cyclative amidation with DBU/TBAB/4 A MS gave respective dihydropyrimidinones in fair to good yields (33-47). The compounds were screened for α-glucosidase inhibitory activity and two (19 and 23) of them showed strong inhibition against rat intestinal α-glucosidase. The compounds were also screened against Mycobacterium aurum, however, only one (19) of them exhibited marginal antitubercular activity.