62465-90-1

Basic information

• Product Name: METHYLCHLORO[(4-CHLOROPHENYL)HYDRAZONO] ACETATE
• Synonyms: METHYLCHLORO[(4-CHLOROPHENYL)HYDRAZONO] ACETATE
• CAS NO: 62465-90-1
• Molecular Formula: C₉H₈Cl₂N₂O₂
• Molecular Weight: 247.08
• Mol File: 62465-90-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 322.7 °C at 760 mmHg
• Flash Point: 149 °C
• Appearance: /
• Density: 1.37 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: METHYLCHLORO[(4-CHLOROPHENYL)HYDRAZONO] ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYLCHLORO[(4-CHLOROPHENYL)HYDRAZONO] ACETATE(62465-90-1)
• EPA Substance Registry System: METHYLCHLORO[(4-CHLOROPHENYL)HYDRAZONO] ACETATE(62465-90-1)

Safety Data

• Hazardous Substances Data: 62465-90-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H8Cl2N2O2/c1-15-9(14)8(11)13-12-7-4-2-6(10)3-5-7/h2-5,12H,1H3/b13-8-

Upstream product

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Downstream Products

• 111068-09-8 1-[(4-Chloro-phenyl)-hydrazono]-1-indazol-2-yl-propan-2-one 
• 136514-90-4 5-(4-Chloro-phenyl)-6-furan-2-yl-2-methyl-1,2,5,6-tetrahydro-[1,2,4,5]tetrazine-3-carboxylic acid methyl ester 
• 136514-79-9 5-(4-Chloro-phenyl)-2-methyl-6-thiophen-2-yl-1,2,5,6-tetrahydro-[1,2,4,5]tetrazine-3-carboxylic acid methyl ester 
• 96722-73-5 1-(4-Chloro-phenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxylic acid 4-ethyl ester 3-methyl ester 
• 113258-75-6 1-methyl-2-indolinone-3-spiro-5'-1'-p-chlorophenyl-3',4'-dimethoxycarbonyl-2'-pyrazoline 
• 69933-92-2 Methyl-2-<2-(4-chlorphenyl)hydrazono>-2-isopropylaminoacetat 
• 57227-00-6 methyl 1-(3-chlorophenyl)-1H-1,2,4-triazole-3-carboxylate 
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Relevant articles and documents

Development of Radiolabeled Ligands Targeting the Glutamate Binding Site of the N-Methyl-d-aspartate Receptor as Potential Imaging Agents for Brain

Abnormal activity of various N-methyl-d-aspartate receptor (NMDAR) subtypes has been implicated in a wide variety of neurological disorders such as Alzheimer's disease, schizophrenia, and epilepsy. Imaging agents for PET and SPECT that target NMDARs in a subtype-selective fashion may enable better characterization of those disorders and enhance drug development. On the basis of a pyrazoline derivative that demonstrated neuroprotective effects in vivo, we synthesized a series of para-substituted analogues and measured their affinities to various NMDAR subtypes. Compounds 4a-c and 4e showed greater, nanomolar affinity for the GluN1/2A subtype versus GluN1/2B. Dicarbomethoxy (pro-drug) analogues of [124/125I]4d and [11C]4e (i.e., [124/125I]11d and [11C]11e) were generated and tested for NMDAR binding specificity in ex vivo autoradiography and brain biodistribution studies. Although NMDAR-specific binding could be demonstrated for [125I]11d and [11C]11e through autoradiography and biodistribution studies, imaging of neither [124I]11d nor [11C]11e could demonstrate brain penetration sufficient for detection by PET.

COPPER(II) IN ORGANIC SYNTHESIS. VI REACTION OF THE COPPER(II) ACETATE COMPLEX OF 1-METHYLISATIN-3-CHLOROPHENYLHYDRAZONE WITH DIMETHYL ACETYLENEDICARBOXYLATE.

The copper(II) complex of 1-methylisatin -3-p-chlorophenylhydrazone (2) reacted with dimethyl acetylenedicarboxylate (DMAD) in accordance to two reaction pathways.Oxidation performed by Cu(2+) gave 1-metyl-3-carbenindolin-2-one (12), trapped by DMAD to gi

Phytotoxic activity in pyrazole derivatives. II

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