6270-17-3

Basic information

• Product Name: ethyl 4-oxo-4-phenylbutyrate
• Synonyms: 3-Benzoylpropionic acid ethyl ester;1-Ethoxy-4-phenylbutane-1,4-dione;4-Oxo-4-phenylbutanoic acid ethyl ester;Ethyl 4-phenyl-4-oxobutyrate
• CAS NO: 6270-17-3
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.24
• EINECS: 228-448-4
• Mol File: 6270-17-3.mol
• Article Data: 94

Chemical Properties

• Boiling Point: 322.5°C at 760 mmHg
• Flash Point: 141.1°C
• Appearance: /
• Density: 1.082g/cm³
• Vapor Pressure: 0.000277mmHg at 25°C
• Refractive Index: 1.505
• CAS DataBase Reference: ethyl 4-oxo-4-phenylbutyrate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-oxo-4-phenylbutyrate(6270-17-3)
• EPA Substance Registry System: ethyl 4-oxo-4-phenylbutyrate(6270-17-3)

Safety Data

• Hazardous Substances Data: 6270-17-3(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Chemistry Letters, 25, p. 633, 1996The Journal of Organic Chemistry, 45, p. 2614, 1980 DOI: 10.1021/jo01301a015Tetrahedron Letters, 29, p. 1457, 1988 DOI: 10.1016/S0040-4039(00)80324-X

InChI:InChI=1/C12H14O3/c1-2-15-12(14)9-8-11(13)10-6-4-3-5-7-10/h3-7H,2,8-9H2,1H3

Upstream product

• 4747-13-1 α-methoxystyrene 
• 105-39-5 chloroacetic acid ethyl ester 
• 64-17-5 ethanol 
• 2051-95-8 succinylbenzene 
• 14308-31-7 2,2-diethoxy-5-phenyl-2,3-dihydro-furan 
• 539-74-2 Ethyl 3-bromopropionate 
• 98-88-4 benzoyl chloride 
• 27374-25-0 [(1-Ethoxycyclopropyl)oxy]trimethylsilane 
• 911641-23-1 bis(2-carboethoxyethyl)zinc 
• 181627-66-7 ethyl 3-benzoyl-2,3-dibromopropionate 
• 75-11-6 diiodomethane 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 17851-98-8 1-phenyl-1-(tributylstannyloxy)ethene 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 53774-19-9 4-phenyl-3-pentenoic acid 
• 80716-63-8 3-benzoyl-4-phenyl-but-3-enoic acid 
• 101430-17-5 2,3-epoxy-3-phenyl-adipic acid diethyl ester 
• 106379-25-3 (5-oxo-2-phenyl-tetrahydro-[2]furyl)-acetic acid ethyl ester 
• 83506-38-1 6-phenyl-2-(3'-phenylpyridazin-6'-yl)-2,3,4,5-tetrahydropyridazin-3-one 
• 80109-13-3 1-Fluoro-4-(4-phenyl-cyclopenta-1,3-dienyl)-benzene 
• 80109-11-1 1-methoxy-4-(4-phenylcyclopenta-1,3-dienyl)benzene 
• 80109-10-0 1-Methyl-3-(4-phenyl-cyclopenta-1,3-dienyl)-benzene 
• 17851-38-6 ethyl 4-cyclohexylbutanoate 
• 787-07-5 diethyl 1,4-cyclohexanedione-2,5-dicarboxylate 
• 130906-53-5 (4-ethoxycarbonyl-5-oxo-2-phenyl-cyclopent-1-enyl)-acetic acid 
• 3360-41-6 4-phenyl-butan-1-ol 
• 2051-95-8 succinylbenzene 
• 74104-14-6 (4-Ethoxy-1-methylene-pent-4-enyl)-benzene 

Relevant articles and documents

Visible-Light-Induced Multicomponent Synthesis of γ-Amino Esters with Diazo Compounds

A visible-light-induced multicomponent reaction of ethyl diazoacetate, diarylamines, and styrene-type alkenes is described. This novel 1,2-difunctionalization of alkenes can be readily achieved under a simple operation and mild conditions, affording γ-amino esters as major products. The reaction proceeds through the generation of carbon-centered radicals from diazo compounds by a visible-light-promoted proton-coupled electron transfer (PCET) process. The carbon radicals then add to diverse alkenes, delivering new carbon radical species, and the final products are formed with N-centered radicals via a radical-radical coupling.

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