627484-44-0

Basic information

• Product Name: 3-chloro-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-propanamide
• CAS NO: 627484-44-0
• Molecular Formula: C₁₂H₁₀ClF₃N₂O₂
• Molecular Weight: 306.67
• Mol File: 627484-44-0.mol

Chemical Properties

• Boiling Point: 469.3°C at 760 mmHg
• Flash Point: 237.6°C
• Density: 1.45g/cm³
• Vapor Pressure: 1.31E-09mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: 3-chloro-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-propanamide(627484-44-0)
• EPA Substance Registry System: 3-chloro-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-propanamide(627484-44-0)

Safety Data

• Hazardous Substances Data: 627484-44-0(Hazardous Substances Data)

Upstream product

• 90357-53-2 N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide 
• 38649-35-3 rac-2-methyloxirane-2-carboxylic acid 
• 143782-18-7 4-isocyanato-2-(trifluoromethyl)benzonitrile 
• 654-70-6 4-amino-2-trifluoromethylbenzonitrile 

Downstream Products

• 90357-51-0 N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide 
• 316373-92-9 N-[4-cyano-3-(trifluoromethyl)-phenyl]-2,3-dihydroxy-2-methyl-propionamide 

Relevant articles and documents

Preparation method of bicalutamide intermediate

The invention provides a preparation method of a bicalutamide intermediate, and in particular relates to a method of preparing 3-chloro-N-(4-cyano-3-trifluromethyl phenyl)-2-hydroxyl-2-methyl propanamide by using N-(4-cyano-3-trifluromethyl phenyl) methacrylamide. The method comprises the following steps: in a solvent, by taking N-(4-cyano-3-trifluromethyl phenyl) methacrylamide as a raw material, adding an acid; cooling the solution to 0-15 DEG C; stirring the mixture; dropwise adding a sodium hypochlorite solution to oxidize; after dropwise addition, keeping the temperature of a reaction system at 0-15 DEG C to perform a reaction for 0.5-1h; and separating and purifying the obtained solution to obtain high-purity 3-chloro-N-(4-cyano-3-trifluromethyl phenyl)-2-hydroxyl-2-methyl propanamide. The preparation method is safe and economical and can be suitable for preparing bicathioether intermediates on a large scale. The raw material is cheap and is easily available, the production period is shortened, and the environmental pollution is not generated.

Novel pathway for the synthesis of arylpropionamide-derived selective androgen receptor modulator (SARM) metabolites of andarine and ostarine

O-Dephenylandarine and O-dephenylostarine, two SARM metabolites relevant for doping control analysis, were synthesized in their endogenous (S)-forms as well as in terms of their racemates. The enantiopure (S)-metabolites were obtained after six steps in 20% and 23% overall yield, the slightly modified racemic route provided the compounds in 28% and 31% total yield, respectively.