62838-65-7

Basic information

• Product Name: 2(1H)-Pyridinone, 3-acetyl- (9CI)
• Synonyms: 2(1H)-Pyridinone, 3-acetyl- (9CI);3-Acetyl-2-hydroxypyridine;3-Acetyl-2(1H)-Pyridinone;2(1H)-Pyridinone, 3-acetyl-;3-acetyl-1,2-dihydropyridin-2-one;3-Acetylpyridin-2(1H)-one;1-(2-Hydroxy-3-pyridinyl)ethanone;3-Acetyl-2(1H)-pyridone
• CAS NO: 62838-65-7
• Molecular Formula: C7H7NO2
• Molecular Weight: 137.13598
• Product Categories: ACETYLGROUP
• Mol File: 62838-65-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 164 °C(Solv: ligroine (8032-32-4); ethanol (64-17-5))
• Boiling Point: 328.725 °C at 760 mmHg
• Flash Point: 152.608 °C
• Appearance: /
• Density: 1.218 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 9.86±0.10(Predicted)
• CAS DataBase Reference: 2(1H)-Pyridinone, 3-acetyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyridinone, 3-acetyl- (9CI)(62838-65-7)
• EPA Substance Registry System: 2(1H)-Pyridinone, 3-acetyl- (9CI)(62838-65-7)

Safety Data

• Hazardous Substances Data: 62838-65-7(Hazardous Substances Data)

Usage

Uses

3-Acetyl-2(1H)-pyridone is a general chemical reagent used in the synthesis of 2,3-disubstituted pyridines. Also used in the synthesis of quinolones

InChI:InChI=1/C7H7NO2/c1-5(9)6-3-2-4-8-7(6)10/h2-4H,1H3,(H,8,10)

Upstream product

• 350-03-8 methyl-3-pyridylketone 
• 14188-94-4 3-acetylpyridine N-oxide 
• 108-24-7 acetic anhydride 
• 109-09-1 2-chloropyridine 
• 131674-39-0 2-chloro-3-(1-hydroxyethyl)pyridine 
• 52200-49-4 3-bromo-2-(phenylmethoxy)pyridine 
• 145143-32-4 2-(phenylmethoxy)-3-<(trimethylsilyl)ethynyl>pyridine 
• 55676-21-6 3-acetyl-2-chloropyridine 

Downstream Products

• 1422462-43-8 2-(3',4'-dihydroxyphenyl)-3-hydroxy-4H-pyrano[2,3-b]pyridine-4-one 
• 1422462-39-2 2-(3',4'-dibenzyloxyphenyl)-3-hydroxy-4H-pyrano[2,3-b]pyridine-4-one 

Relevant articles and documents

A nitrogen oxide C2 - bit hydroxylated method (by machine translation)

The present invention relates to nitrogen oxide C2 - bit hydroxylated method, in particular under reflux conditions in dichloroethane, three pyrrole alkyl bromide (PyBrop) [...] phosphate, sodium acetate, water and nitrogen oxides produced by the reaction of hydroxyl-substituted product. The process has simple operation, mild condition, high reaction selectivity, substrate wide applicability, high yield and the like. The application for the first time using this method to synthesize a series of 2 - hydroxyquinoline, 2 - hydroxy pyridine and 1 - hydroxy isoquinoline compound, in the establishment of the compounds of the library synthesis application have broad prospects. (by machine translation)

Novel synthesis of tetrahydro-2(1H)-quinolones using Diels-Alder reactions of 1-arylsulfonyl-2(1H)-pyridones having an electron-withdrawing group

A novel synthetic methodology of preparing tetrahydro-2(1H)-quinolones by Diels-Alder reactions between 2-methyl- and 2,3-dimethyl-1,3-butadienes and 1-arylsulfonyl-2(1H)-pyridones having an electron-withdrawing group at the 5-position is presented. Furthermore, the site-selectivity analyses based on MO calculations of the 5-substituted 2(1H)-pyridones acting as the dienophiles are described.

Improved Synthesis of 2,3-Disubstituted Pyridines by Metallation of 2-Chloropyridine: a Convenient Route to Fused Polyheterocycles

Chemoselective directed metallation of 2-chloropyridine allows the synthesis of 2-substituted 3-carbonylated pyridines, advantage being taken of the metallation ortho-directing effect of the halogen, as well as its reactivity towards nucleophiles.Thus (2-chloro-, 2-methoxy-, and 2-amino-3-pyridyl)-ethanones and -arylmethanones as well as carbaldehydes have been prepared.Some of these ortho-disubstituted intermediates have been readily cyclized to fused polyheterocycles such as naphthiridines and aza-analoges of coumarins, xanthones, and acridones.