628691-85-0

Basic information

• Product Name: 2,4-dichloro-3-fluoropyridine
• Synonyms: 2,4-dichloro-3-fluoropyridine;4,6-dichloro-3-fluoro-pyridine;2-chloro-3-fluoro-4-chloropyridine
• CAS NO: 628691-85-0
• Molecular Formula: C₅H₂Cl₂FN
• Molecular Weight: 165.9804832
• Mol File: 628691-85-0.mol

Chemical Properties

• Boiling Point: 187.7°C at 760 mmHg
• Flash Point: 67.3°C
• Appearance: /
• Density: 1.498g/cm³
• Vapor Pressure: 0.858mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.13±0.10(Predicted)
• CAS DataBase Reference: 2,4-dichloro-3-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dichloro-3-fluoropyridine(628691-85-0)
• EPA Substance Registry System: 2,4-dichloro-3-fluoropyridine(628691-85-0)

Safety Data

• Hazardous Substances Data: 628691-85-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dichloro-3-fluoropyridine is used as a key intermediate in the synthesis of (aza)indazolyl-aryl sulfonamide and related compounds. These compounds are designed to inhibit the activity of GCN2, a protein kinase involved in the regulation of cellular stress responses and protein synthesis. By targeting GCN2, these compounds have potential applications in the development of treatments for various diseases and conditions where the modulation of GCN2 activity can be therapeutically beneficial.
Additionally, 2,4-dichloro-3-fluoropyridine can be utilized in the preparation of other bioactive molecules and drug candidates, given its reactivity and the ability to form diverse chemical linkages with other molecular moieties. Its presence in the final products can contribute to the desired pharmacological properties, such as improved potency, selectivity, and pharmacokinetics.

InChI:InChI=1/C5H2Cl2FN/c6-3-1-2-9-5(7)4(3)8/h1-2H

Upstream product

• 17282-04-1 2-chloro-3-fluoropyridine 

Downstream Products

• 1446020-95-6 N-((1S)-1-(4-(1-(2-((2,2-difluorocyclopropyl)methoxy)-3-fluoropyridin-4-yl)azetidin-3-yl)phenyl)ethyl)acetamide 
• 1446021-33-5 C₁₈H₁₉ClFN₃O 
• 1620686-12-5 C₂₂H₂₅F₃N₄O₂ 
• 1620690-31-4 C₂₄H₃₁FN₄O₃ 
• 1620690-65-4 N-((S)-1-(4-((R)-1-(2-chloro-3-fluoropyridin-4-yl)pyrrolidin-3-yloxy)phenyl)ethyl)acetamide 

Relevant articles and documents

POLYSUBSTITUTED PYRIDINE COMPOUND, PREPARATION METHOD, USE AND PHARMACEUTICAL COMPOSITION

The present invention provides a polysubstituted pyridine compound of Formula I, a preparation method, a use and a pharmaceutical composition thereof. The polysubstituted pyridine compound of Formula I according to the present invention has an excellent anti-tumor effect, can inhibit various cell kinases simultaneously, has significantly excellent pharmacokinetic characteristics, and is very suitable for oral and intravenous administration. The pharmaceutical composition according to the present invention can be useful for treating tumors and cancers.

IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

A class of 8-fluoro-3-phenylimidazo[1,2-a]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group, or by a pyrrolidinonyl group, which is directly attached or bridged by an oxygen atom or by a -NH- or -OCH2- linkage, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.