62999-96-6Relevant articles and documents
n-Type Rigid Semiconducting Polymers Bearing Oligo(Ethylene Glycol) Side Chains for High-Performance Organic Electrochemical Transistors
Chen, Xingxing,Marks, Adam,Paulsen, Bryan D.,Wu, Ruiheng,Rashid, Reem B.,Chen, Hu,Alsufyani, Maryam,Rivnay, Jonathan,McCulloch, Iain
, p. 9368 - 9373 (2021)
N-type conjugated polymers as the semiconducting component of organic electrochemical transistors (OECTs) are still undeveloped with respect to their p-type counterparts. Herein, we report two rigid n-type conjugated polymers bearing oligo(ethylene glycol
Syntheses and properties of a series of cationic water-soluble phthalocyanines
Li, Hairong,Jensen, Timothy J.,Fronczek, Frank R.,Vicente, M. Gra?a H.
, p. 502 - 511 (2008)
A series of symmetrical cationic phthalocyanines (Pcs) with either Zn(II) or Si(IV) metal ions and two bulky axial ligands on the silicon complexes was synthesized in high yields. The photophysical (absorption, emission, fluorescence, and singlet oxygen q
Synthesis of new hetero-arylidene-9(10H)-anthrone derivatives and their biological evaluation
Baptista, Pedro V.,Branco, Paula S.,Fernandes, Alexandra R.,Malta, Gabriela,Peixoto, Daniela,Roma-Rodrigues, Catarina,Ferreira, Luísa M.
, (2020/04/22)
New hetero-arylidene-9(10H)-anthrone derivatives (1) were synthesized from reaction of 1,2-dimethyl-3-alkyl imidazolium salts (2) and 9-anthracenecarboxaldehyde. Ion exchange of the anion with dioctyl sulfosuccinate and lithium bis(trifluoromethanesulfonyl)imide led to the preparation of other derivatives. The antiproliferative effect of the compounds was evaluated in human ovarian (A2780) and colorectal (HCT116) carcinoma cell lines and in normal primary human fibroblasts. Compound 1 presented an antiproliferative effect related to the imidazolium pattern of substitution with compounds having a decyl group at the R-position (1c and 3c) showing the highest cytotoxic activities in all cell lines independently of the counter ion. Compounds 1b and 1c internalize A2780 cancer cells via a passive or an active transport, respectively, inducing A2780 cell death via an extrinsic apoptosis (1b) or intrinsic apoptosis and oncosis (1c). The localization of both compounds in the cytoplasm coupled to the absence of reactive oxygen species (ROS) induction suggest that the mechanisms of toxicity might be different than those of other anthracyclines currently used in chemotherapy.
BENZOSELNOPHENE-BASED COMPOUND AND ANTIBODY-DRUG CONJUGATE CONTAINING THE SAME
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Paragraph 0293-0294, (2017/08/02)
The present invention relates to a benzoselnophene-based compound, and a preparation method thereof, and antibody-drug conjugate (ADC) containing the benzoselnophene-based compound. The present invention provides the benzoselnophene-based compound or a sa
Langmuir-Blodgett films of perylene bisimide derivatives and fluorescent recognition of diamines
Shang, Congdi,Wang, Li,An, Yanqin,Chen, Ping,Chang, Xingmao,Qi, Yanyu,Kang, Rui,Fang, Yu
, p. 23898 - 23904 (2017/09/22)
Fast, sensitive and selective detection of diamines in the vapor phase is of pivotal importance for air and food quality monitoring. In this work, an electron-poor fluorophore, perylene bisimide (PBI), was modified with hydrophilic residues at its bay positions, resulting in an amphiphilic derivative, PEBBO. Photophysical studies revealed that the compound shows a strong aggregation tendency in various solvents, but the aggregates could be highly fluorescent provided suitable solvents are used. Accordingly, a fluorescent film was constructed via utilization of the well-known Langmuir-Blodgett technique. Sensing performance studies revealed that the film as prepared is sensitive and selective to the presence of diamines in air. Specifically, (1) the experimental detection limit is lower than 0.016 g m-3 and the linear range of the analysis extends from 0.33 g m-3 to 8.20 g m-3 when ethylenediamine was adopted as an example analyte; (2) the presence of other amines and solvents shows little effect upon detection; (3) the response time is less than 5 s. Considering the importance of diamine sensing, the convenience of fluorescence techniques and the superiorities of the film and method as developed, it is believed that the present work is of great importance for promoting technical progress in diamine sensing.
Synthesis of pyrrolidinium-based poly(ionic liquid) electrolytes with poly(ethylene glycol) side chains
Doebbelin, Markus,Azcune, Itxaso,Bedu, Melanie,Ruiz De Luzuriaga, Alaitz,Genua, Aratz,Jovanovski, Vasko,Cabanero, German,Odriozola, Ibon
experimental part, p. 1583 - 1590 (2012/08/13)
The synthesis and characterization of a new family of pyrrolidinium based poly(ionic liquid) (PIL) electrolytes with poly(ethylene glycol) (PEG) pendant groups is reported. The PILs were synthesized from a diallyl methyl amine hydrochloride monomer, which
OPHTHALMIC COMPOSITIONS
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Page/Page column 4-5, (2012/05/07)
The present invention relates to compositions that may alleviate symptoms of ocular stress, as well as methods of their production, use, and storage compositions. The compositions comprise at least one ocular epithelial cell associating group and at least one hydrophilic group. In one embodiment the at least one ocular epithelial cell associating group and at least one hydrophilic group are substituents on a conjugated polyaromatic core. The compositions may be used in ophthalmic compositions and ophthalmic devices.
Synthesis and mesomorphic properties of rigid-core ionic liquid crystals
Kouwer, Paul H. J.,Swager, Timothy M.
, p. 14042 - 14052 (2008/09/17)
Ionic liquid crystals combine the unique solvent properties of ionic liquids with self-organization found for liquid crystals. We report a detailed analysis of the structure-property relationship of a series of new imidazolium-based liquid crystals with an extended aromatic core. Investigated parameters include length and nature of the tails, the length of the rigid core, the lateral substitution pattern, and the nature of the counterion. Depending on the molecular structure, two mesophases were observed: a bilayered SmA 2 phase and the more common monolayered SmA phase, both strongly interdigitated. Most materials show mesophases stable to high temperatures. For some cases, crystallization could be suppressed, and room-temperature liquid crystalline phases were obtained. The mesomorphic properties of several mixtures of ionic liquid crystals were investigated. Many mixtures showed full miscibility and ideal mixing behavior; however, in some instances we observed, surprisingly, complete demixing of the component SmA phases. The ionic liquid crystals and mixtures presented have potential applications, due to their low melting temperatures, wide temperature ranges, and stability with extra ion-doping.
Investigations on the influence of 2'-O-alkyl modifications on the base pairing properties of oligonucleotides
Werner, Doris,Brunar, Helmut,Noe, Christian R.
, p. 3 - 10 (2007/10/03)
The antisense strategy has gained wide acceptance as a promising drug development concept. Antisense drugs hybridize with selected complementary sequences in a highly specific manner. However, as a main prerequisite for extensive therapeutic use of this new class of drugs, selected structural modifications are required to adjust pharmacokinetic and pharmacodynamic behavior. In continuation of our earlier investigations on 2'-O-modified oligonucleotides (Gotten, M., Oberhauser, B., Brunar, H., Holzner, A., Issakides, G., Noe, C.R., Schaffer, G., Wagner, E., Bimstiel, M.L., 1991. 2'-O-methyl, 2'-O-ethyl oligoribonucleotides and phosphorothioate oligodeoxyribonucleotides as inhibitors of the in vitro U7 snRNP-dependent mRNA processing event. Nucleic Acids Res. 19, 2629-2635; Wagner, E., Oberhauser, B., Holzner, A., Brunar, H., Issakides, G., Schaffner, G., Gotten, M., Knollmuller, M., Noe, C.R., 1991. A simple procedure for the preparation of protected 2'-O-methyl or 2'-O-ethyl ribonucleoside-3'-O-phosphoramidites. Nucleic Acids Res. 19, 5965-5971) further series of modified oligonucleotides containing different modified 2'-O-adenosines have been synthesized. On the one hand linear alkyl moieties of increasing length, on the other hand oxyethylene moieties of corresponding length were introduced at the 2'-O-position of adenosine. Following another approach a cationic charge was introduced by insertion of an aminohexylmodification at the 2'-O-position of adenosine (Brunar, H., Haberhauer, G., Werner, D., Noe, C.R., 1994. 2'-O-Modified oligonucleotides: Synthesis and biophysical analysis. Eur. J. Pharm. Sci. 2, 150). Molecule dynamics simulations had shown that this cationic modification upon duplex formation leads to both intra- and interstrand interactions. To determine the influence of the different modifications, such as cationic charge, alkyl chainlength and introduction of oxygen into the chain, on duplex stability melting temperatures were measured by recording circular dichroism versus temperature.
Photoresponsive Supramolecular Systems: Synthesis and Photophysical and Photochemical Study of Bis-(9,10-anthracenediyl)coronands AAOnOn
Marquis, Damien,Desvergne, Jean-Pierre,Bouas-Laurent, Henri
, p. 7984 - 7996 (2007/10/03)
Monocyclic bis-(9,10-anthracenediyl)coronands denoted AAOnOn (A = (9,10-anthracenediyl, n indicating the number of ethyleneoxy repeating units between two aromatic rings) were designed as photoresponsive systems.Their synthesis is described; their spectroscopic properties were found to be in agreement with the X-ray structures.Special attention was devoted to AAO5O5, which gives coronates with Na(1+) and K(1+).It was observed that one molecule of AAO5O5 displays a positive cooperative effect in binding two sodium cations, in contrast with previous reports on bicyclic coronands.Moreover, in acetonitrile, this effect, clear in the ground state (K11 = 180 M-1, K1,2 = 240 M-1) was found to be stronger in the excited state (K11 = 200 M-1, K1,2 = 500 M-1).With K(1+), AAO5O5 generates a 1:1 complex (K ca. 9 M-1 in methanol).Spectroscopic properties were shown to be triggered by cation concentration, specifically the fluorescence emission which undergoes an important intensity and wavelength redistribution in favor of the excimer: the maximum wavelength is shifted from 530 nm (free ligand) to 570 nm (sodium biscoronate), i.e., Δ ca. 1350 cm-1 and the excimer intensity is multiplied by ca. 3.The photocyclomerization (intramolecular dimerization of the anthracene nucleus) was demonstrated to be regiospecifically directed by Na(1+); in methanol, the free receptor exclusively generates the 9,10:1',4' photoadduct (ΦR ca. 2E-4) whereas the sodium biscoronate leads to the classical 9,10:9',10' photoadduct (ΦR ca. 8E-3).Finally, a transient kinetic analysis versus temperature allowed the determination of the conformational mobility of the free receptor within the nanosecond range; in the singlet excited state it is best described by the sequence M1* -> M2* -> E where M* stands for the locally excited state and E the excimer state species.At room temperature, in methanol, excimer lifetimes were found to be as follows: free ligand, 23 ns; sodium biscoronate, 165 ns; and potassium monocoronate, 215 ns.
