6310-87-8Relevant articles and documents
Palladium-Catalyzed C-H Functionalization of Aromatic Oximes: A Strategy for the Synthesis of Isoquinolines
Zhu, Zhongzhi,Tang, Xiaodong,Li, Xianwei,Wu, Wanqing,Deng, Guohua,Jiang, Huanfeng
, p. 1401 - 1409 (2016/03/01)
An efficient strategy for synthesis of isoquinolines via Pd(II)-catalyzed cyclization reaction of oximes with vinyl azides or homocoupling of oximes is reported. Oximes could serve as a directing group and an internal oxidant in the transformation. This reaction features good functional group tolerance and provides a useful protocol for the synthesis of different kinds of isoquinolines under mild conditions. Some control experiments and 15N isotope labeling experiments were conducted for the mechanistic research. (Chemical Equation Presented).
Synthesis of β-blocking oximes. Influence of terminal amine on β-selectivity
Amlaiky,Leclerc,Decker,Schwartz
, p. 437 - 439 (2007/10/02)
Three series of oximinopropanolamine derivatives in which the terminal nitrogen has been substituted by various arylalkyl groups were synthesized. The beta-adrenergic blocking activity of the 21 compounds was determined in vitro on the guinea-pig. The structure-activity relationship is discussed.