6319-54-6

Basic information

• Product Name: 1-(9H-xanthen-9-yl)pyrrolidine-2,5-dione
• CAS NO: 6319-54-6
• Molecular Formula: C₁₇H₁₃NO₃
• Molecular Weight: 279.29
• Mol File: 6319-54-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 457.8°C at 760 mmHg
• Flash Point: 230.7°C
• Density: 1.372g/cm³
• Vapor Pressure: 1.44E-08mmHg at 25°C
• Refractive Index: 1.666
• CAS DataBase Reference: 1-(9H-xanthen-9-yl)pyrrolidine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(9H-xanthen-9-yl)pyrrolidine-2,5-dione(6319-54-6)
• EPA Substance Registry System: 1-(9H-xanthen-9-yl)pyrrolidine-2,5-dione(6319-54-6)

Safety Data

• Hazardous Substances Data: 6319-54-6(Hazardous Substances Data)

Usage

General Description

1-(9H-xanthen-9-yl)pyrrolidine-2,5-dione, also known as Thioxanthen-9-one, is an organic compound with the molecular formula C21H11NO2. It is a xanthene derivative with a pyrrolidine-2,5-dione group. This chemical is used in the synthesis of various pharmaceutical compounds and as a dye precursor. It has also been studied for its potential applications in organic electronics. Its unique structure and properties make it a valuable building block in organic chemistry and material science research.

Upstream product

• 90-46-0 9-hydroxyxanthene 
• 123-56-8 Succinimide 
• 128-08-5 N-Bromosuccinimide 
• 92-83-1 xanthene 
• 82-07-5 xanthene-9-carboxylic acid 
• 105251-69-2 3-<(9H-xanthen-9-yl)aminocarbonyl>propionic acid 

Relevant articles and documents

Synthesis of new xanthene derivatives with expected antischistosomal activity

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Electrochemical Decarboxylative N-Alkylation of Heterocycles

An operationally simple method to employ nonactivated carboxylic acids as alkylating agents in the N-alkylation of heterocycles is reported through an electrochemically driven anodic decarboxylative process. A wide substrate scope across a range of heterocycles is demonstrated along with a series of applications that significantly reduce the step count required to access such medicinally relevant structures.

Gastric antisecretory 9H-xanthen-9-amines

A series of 9H-xanthen-9-amines possessing a wide variety of nitrogen substituents at C-9 was prepared for evaluation of gastric antisecretory activity. These substituents included the acetamidine, imidate, pyrimidine, thiazoline, quinuclidine, 2-hydrazinopyridine, aminopiperidine, aminoalkylimidazole, and aminoalkylpyridine moieties. The majority of compounds in this series inhibited gastric acid secretion when tested orally in the pylorus-ligated rat. Potency was increased by intraduodenal administration and diminished by incubation with gastric juice, suggesting partial degradation of the compounds in the gastric environment. A representative example, 3-(9H-xanthen-9-ylamino)-1-ethylpiperidine, exhibited similar activity in dogs, although no free compound could be detected in the blood. It is therefore hypothesized that this compound is either rapidly bound to tissue and/or metabolized to an active species.