6323-86-0

Basic information

• Product Name: 1-[2-(2-hydroxyphenyl)-2-oxoethyl]pyridinium
• CAS NO: 6323-86-0
• Molecular Formula: C₁₃H₁₂NO₂*I
• Molecular Weight: 214.2393
• Mol File: 6323-86-0.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 1-[2-(2-hydroxyphenyl)-2-oxoethyl]pyridinium(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(2-hydroxyphenyl)-2-oxoethyl]pyridinium(6323-86-0)
• EPA Substance Registry System: 1-[2-(2-hydroxyphenyl)-2-oxoethyl]pyridinium(6323-86-0)

Safety Data

• Hazardous Substances Data: 6323-86-0(Hazardous Substances Data)

Usage

Chemical structure

A pyridinium derivative containing a hydroxyphenyl and oxoethyl group

Usage

Commonly used as a reactant in organic synthesis and pharmaceutical research

Applications

Potential use in the development of new drugs and therapeutic agents due to its pharmacological properties

Additional uses

May have uses as a reagent in chemical analysis and as a component in the production of specialty chemicals

Context dependency

Specific uses and effects may depend on the context and the specific formulation in which it is used

Upstream product

• 110-86-1 pyridine 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 34611-43-3 2,5-dibenzylidene cyclopentanone 

Relevant articles and documents

Design, synthesis, and structure-activity relationships of new benzofuro[3,2-b]pyridin-7-ols as DNA topoisomerase II inhibitors

Human DNA topoisomerases have become attractive targets for developing more effective anticancer drugs. In this study, a series of new benzofuro[3,2-b]pyridin-7-ols were designed and synthesized for the first time and screened for their topoisomerase I and II inhibitory and antiproliferative activity. Structure-activity relationships revealed the position of ortho- and para-hydroxyl group at 2-phenyl ring, and meta-hydroxyl group at 4-phenyl ring of benzofuro[3,2-b]pyridin-7-ol are important for potent and selective topo II inhibitory activity. Compound 11 showed the most selective and potent topo II inhibition (100% inhibition at 100 μM) and strongest antiproliferative activity (IC50 = 0.86 μM) than all the positive controls in HeLa cell line.

Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines: Topoisomerase I and IIα dual inhibitors with DNA non-intercalative catalytic activity

With the aim to develop novel antiproliferative agents, a new series of eighteen dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines were systematically designed, prepared, and investigated for their topoisomerase (topo) I and IIα inhibitory properties an

Effect of chlorine substituent on cytotoxic activities: Design and synthesis of systematically modified 2,4-diphenyl-5H-indeno[1,2-b]pyridines

In continuation of our previous work, six hydroxylated 2,4-diphenyl-5H-indeno[1,2-b]pyridine analogs were modified by introducing one chlorine functionality at ortho, meta or para position of the 2- or 4-phenyl ring. Eighteen new chlorinated compounds wer