63261-41-6

Basic information

• Product Name: 2-Propen-1-one, 1-cyclopropyl-3-phenyl-, (2E)-
• Synonyms: benzylidenemethyl cyclopropyl ketone;(E)-1-cyclopropyl-3-phenyl-2-propenone;(E)-1-cyclopropyl-3-phenylpropen-1-one;cyclopropyl styryl ketone;2-phenylvinyl cyclopropyl ketone;1-Cyclopropyl-3-phenyl-2-propen-1-one;2-Propen-1-one,1-cyclopropyl-3-phenyl-,(2E);UPCMLD0ENAT0400-2948:001
• CAS NO: 63261-41-6
• Molecular Formula: C12H12O
• Molecular Weight: 172.227
• Mol File: 63261-41-6.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1-cyclopropyl-3-phenyl-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-cyclopropyl-3-phenyl-, (2E)-(63261-41-6)
• EPA Substance Registry System: 2-Propen-1-one, 1-cyclopropyl-3-phenyl-, (2E)-(63261-41-6)

Safety Data

• Hazardous Substances Data: 63261-41-6(Hazardous Substances Data)

Upstream product

• 765-43-5 Cyclopropyl methyl ketone 
• 100-52-7 benzaldehyde 
• 6783-05-7 trans-2-phenylvinylboronic acid 
• 1489-69-6 Cyclopropanecarboxaldehyde 
• 54454-39-6 Triphenyl-{1-[2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-cyclopropyl}-phosphonium; bromide 
• 7691-76-1 1-cyclopropyl-2-(triphenyl-λ⁵-phosphanylidene)ethan-1-one 
• 298-14-6 potassium hydrogencarbonate 

Downstream Products

• 136120-65-5 1-cyclopropyl-3-phenyl-1-propanone 
• 100904-80-1 2,3-dibromo-1-cyclopropyl-3-phenyl-propan-1-one 
• 125219-65-0 2-dicyanomethylene-4-phenyl-3-cyano-6-cyclopropyl-1,2-dihydropyridine 
• 1075277-37-0 methyl 5-cyclopropyl-2-nitro-5-oxo-3-phenylpentanoate 
• 1252048-31-9 C₁₉H₁₇ClN₂O 
• 1391744-87-8 2-benzyl-1-cyclopropyl-3-hydroxy-3-phenylpropan-1-one 

Relevant articles and documents

Synthesis of Ketones by C?H Functionalization of Aldehydes with Boronic Acids under Transition-Metal-Free Conditions

A method for the synthesis of ketones from aldehydes and boronic acids via a transition-metal-free C?H functionalization reaction is reported. The method employs nitrosobenzene as a reagent to drive the simultaneous activation of the boronic acid as a boronate and the activation of the C?H bond of the aldehyde as an iminium species that triggers the key C?C bond-forming step via an intramolecular migration from boron to carbon. These findings constitute a practical, scalable, and operationally straightforward method for the synthesis of ketones.

Asymmetric transfer hydrogenation of cycloalkyl vinyl ketones to allylic alcohols catalyzed by ruthenium amido complexes

A chemoselective 1,2-reduction of cycloalkyl vinyl ketones via asymmetric transfer hydrogenation is described. The reduction proceeded smoothly with a chiral diamine ruthenium complex as a catalyst and a HCOOH-NEt3 azeotrope as both a hydrogen source and solvent under mild conditions. A wide range of 1-cycloalkyl chiral allylic alcohols were obtained in good yields and up to 87% ee. It was found that the alkyl group plays an important role in the enantioselectivity.

Palladium-Catalyzed Cleavage of α-Allenylic Aryl Ether toward Pyrazolemethylene-Substituted Phosphinyl Allenes and Their Transformations via Alkenyl C-P(O) Cleavage

A palladium-catalyzed two-component coupling of allenylphosphine oxides with conjugated N-tosylhydrazones is revealed. For the first time, the cleavage of α-allenylic aryl ether toward pyrazolemethylene-substituted phosphinyl allenes enabled facile synthesis of combined motifs with pyrazole and allene. Moreover, the obtained adducts could be easily transformed to potential bioactive multifunctionalized phosphinates via a novel alkenyl C-P(O) cleavage.