63271-82-9Relevant articles and documents
Triazino benzodiazepines
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, (2008/06/13)
Compounds of formula IV: STR1 wherein R and R1 are hydrogen or alkyl of 1 to 3 carbon atoms, inclusive; wherein R2 is hydrogen or methyl; wherein R3 is hydrogen, fluoro, chloro, bromo, trifluoromethyl or nitro; and wherein Ar is phenyl, o-chlorophenyl, o-fluorophenyl, 2,6-difluorophenyl or 2-pyridyl, are produced by reacting a hydrazino compound of the formula I STR2 wherein R2, R3, and Ar are defined as above, with a carbonyl reagent of the formula II: STR3 wherein R and R1 are defined as above and Y is chloro, bromo, iodo or in which R4 is alkyl, defined as above, phenyl, or tolyl, to give the compound III: STR4 wherein R, R1, R2, R3, Ar, and Y are defined as above and heating compound III, in an inert organic solvent, to give compound IV above. The compounds of formula IV of this invention and the pharmacologically acceptable acid addition salts thereof are sedatives, tranquilizers and muscle-relaxants and can be used for such purposes in mammals and birds.