6328-48-9

Basic information

• Product Name: 3-(Benzyloxy)propionitrile
• Synonyms: 3-(phenylmethoxy)-propanenitril;3-(phenylmethoxy)-Propanenitrile;Propanenitrile,3-(phenylmethoxy)-;3-BENZYLOXYPROPIONITRILE;3-(Benzyloxy)propiononitrile;3-(BENZYLOXY)PROPANENITRILE;2-Cyanoethylbenzyl ether;Benzyl 2-cyanoethyl ether
• CAS NO: 6328-48-9
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.2
• EINECS: 228-698-4
• Product Categories: Aromatic Nitriles
• Mol File: 6328-48-9.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 297.7 °C at 760 mmHg
• Flash Point: 125.4 °C
• Appearance: /
• Density: 1.039 g/cm³
• Vapor Pressure: 0.00133mmHg at 25°C
• Refractive Index: 1.514
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-(Benzyloxy)propionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Benzyloxy)propionitrile(6328-48-9)
• EPA Substance Registry System: 3-(Benzyloxy)propionitrile(6328-48-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 6328-48-9(Hazardous Substances Data)

Usage

General Description

3-(Benzyloxy)propionitrile, also known as BzOPN, is a chemical compound with the molecular formula C10H11NO. It consists of a benzyl group attached to the oxygen of a propionitrile group. It is a clear, colorless liquid with a slightly sweet odor, and it is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. BzOPN is commonly employed as a building block in the production of pharmaceutical drugs, such as anti-cancer agents and analgesics. Additionally, it is utilized as a precursor in the synthesis of fine chemicals and as a reagent in organic chemistry reactions. Overall, 3-(Benzyloxy)propionitrile is an important and versatile chemical compound with numerous industrial and pharmaceutical applications.

InChI:InChI=1/C10H11NO/c11-7-4-8-12-9-10-5-2-1-3-6-10/h1-3,5-6H,4,8-9H2

Upstream product

• 107-13-1 acrylonitrile 
• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 109-78-4 3-Hydroxypropionitrile 
• 100-46-9 benzylamine 
• 140-11-4 Benzyl acetate 
• 110-67-8 3-Methoxypropionitrile 
• 1904-22-9 3-[(1-phenylprop-2-yn-1-yl)oxy]propanenitrile 
• 74-86-2 acetylene 

Downstream Products

• 19790-60-4 3-Benzyloxypropanal 
• 107-10-8 propylamine 
• 16728-64-6 3-benzyloxypropylamine 
• 100-51-6 benzyl alcohol 
• 388095-22-5 1-[2-(benzyloxy)ethyl]cyclopropan-1-amine 
• 27912-85-2 3-(benzyloxy)propanoic acid 
• 4244-66-0 3-benzyloxypropionyl chloride 
• 119027-79-1 5-Benzyloxycarbonylamino-2-(3-benzyloxy-propionylamino)-pentanoic acid 
• 119027-79-1 L-β-benzyloxypropionyl-carbobenzoxyrnithine 
• 119027-78-0 2-(3-Benzyloxy-propionylamino)-pentanedioic acid dibenzyl ester 
• 119027-78-0 L-β-benzyloxypropionyl-dibenzylglutamate 
• 119027-80-4 5-Benzyloxycarbonylamino-2-(3-benzyloxy-propionylamino)-pentanoic acid benzyl ester 
• 119027-80-4 L-β-benzyloxypropionyl-carbobenzoxyornithine benzyl ester 
• 107273-07-4 2-phenyl-3-tosyl-1,3-oxazinane 

Relevant articles and documents

Preparation method of 3-aminopropanol

The invention relates to a preparation method of 3-aminopropanol, wherein the preparation method comprises the following steps: (1) carrying out a reaction on acrylonitrile with benzyl alcohol under the catalysis of a base catalyst, and separating the obtained reaction solution to obtain 3-benzyloxypropionitrile; and (2) in a liquid-phase reaction system in the presence of a hydrogenation catalyst, carrying out a hydrogenation reaction on the 3-benzyloxypropionitrile, separating the obtained reaction liquid to obtain 3-aminopropanol, and recycling the obtained by-product toluene as an extractant in the step (1).

Formation of a New, Strongly Basic Nitrogen Anion by Metal Oxide Modification

Development of new hybrid materials having unique and unprecedented catalytic properties is a challenge for chemists, and heterogeneous-homogeneous hybrid catalysts have attracted much attention because of the preferable and exceptional properties that are highly expected to result from combination of the components. Base catalysts are widely used in organic synthesis as key materials, and a new class of base catalysts has made a large impact from academic and industrial viewpoints. Here, a principle for creating a new strong base by hybridization of homogeneous and heterogeneous components is presented. It is based on the modification of organic compounds with metal oxides by using the acid-base property of metal oxides. Based on kinetic and DFT studies, combination of CeO2 and 2-cyanopyridine drastically enhanced the basicity of 2-cyanopyridine by a factor of about 109 (～9 by pKa (in CH3CN)), and the pKa was estimated to be ～21, which locates it in the superbase category. 2-Cyanopyridine and CeO2 formed a unique adsorption complex via two interaction modes: (i) coordinative interaction between the Ce atom of CeO2 and the N atom of the pyridine ring in 2-cyanopyridine, and (ii) covalent interaction between the surface O atom of CeO2 and the C atom of the CN group in 2-cyanopyridine by addition of the lattice oxygen of CeO2 to the CN group of 2-cyanopyridine. These interactions established a new, strongly basic site of N- over the CeO2 surface.

PARTIALLY SATURATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND

There are provided compounds having a superior PHD2 inhibitory effect that are represented by general formula (I'): (in the above-mentioned general formula (I'), W, Y, R2, R3, R4, and Y4 are as described hereinabove), or pharmaceutically acceptable salts thereof.