63365-14-0

Basic information

• Product Name: Benzonitrile, 2-amino-6-(1-piperidinyl)-
• CAS NO: 63365-14-0
• Molecular Formula: C12H15N3
• Molecular Weight: 201.271
• Mol File: 63365-14-0.mol

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 2-amino-6-(1-piperidinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 2-amino-6-(1-piperidinyl)-(63365-14-0)
• EPA Substance Registry System: Benzonitrile, 2-amino-6-(1-piperidinyl)-(63365-14-0)

Safety Data

• Hazardous Substances Data: 63365-14-0(Hazardous Substances Data)

Upstream product

• 63365-13-9 2-nitro-6-(1-piperidinyl)benzonitrile 
• 110-89-4 piperidine 
• 35213-00-4 2,6-dinitrobenzonitrile 
• 77326-36-4 2-amino-6-fluorobenzonitrile 

Downstream Products

• 69213-38-3 N-[2-cyano-3-(1-piperidinyl)phenyl]1-(4-methoxyphenylmethyl)-1H-tetrazole-5-carboxamide 
• 63365-15-1 [2-Cyano-3-(1-Piperidinyl)Phenylamino]Oxoacetic Acid Ethyl Ester 
• 63365-22-0 [3-Amino-2-Cyanophenylamino]Oxoacetic Acid Ethyl Ester 
• 749268-55-1 2-Amino-6-piperidin-1-yl-benzylamine 
• 54249-44-4 ethyl ((2-(aminocarbonyl)-3-methoxyphenyl)amino)(oxo)acetate 

Relevant articles and documents

Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists

The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.

Antifolate and Antibacterial Activities of 5-Substituted 2,4-Diaminoquinazolines

A series of 5-substituted 2,4-diaminoquinazolines (3) has been synthesized and evaluated as inhibitors of the enzyme dihydrofolate reductase (DHFR) from both bacterial and mammalian sources.The best compounds (e.g. 53) show good activity against Escherichia coli DHFR, but there is no significant selectivity for the bacterial over the mammalian enzyme.The structure-activity relationships for enzyme inhibition appear to be complex and not amenable to simple analysis; a hypotesis to explain the observed qualitative structure-activity relationships is proposed.The inhibitory activities of the compounds against the growth of intact bacterial cells in vitro closely parallel those for the inhibition of the isolated bacterial enzymes, suggesting that their antifolate action is responsible for their antibacterial effects.Five of the compounds were tested for their ability to cure a systemic E. coli infection in the mouse, but they showed no therapeutic effects at their maximum tolerated doses.

Imidazoquinazolin-2-one compounds

Imidazoquinazolin-2-one compounds having platelet aggregation inhibitory activity is disclosed. These compounds have high water-solubility and reduced influences on the circulatory system and are useful for treatment and prophylaxis of intravascular throm

Cyclic guanidines. 17. Novel (N-substituted amino)imidazo[2,1-b]quinazolin-2-ones: Water-soluble platelet aggregation inhibitors

A series of novel 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one derivatives substituted with a secondary amino group has been prepared and tested for the activities of inhibiting platelet aggregation in rats in vitro and ex vivo. Most of the compounds

N-(Aminophenyl)oxamic Acids and Esters as Potent, Orally Active Antiallergy Agents

A series of N-(2-cyano-substituted-phenyl)oxamates was prepared by acylation of the appropriate anthranilonitrile with ethyloxalyl chloride.Hydrolysis with sodium hydroxide gave the corresponding oxamic acid sodium salts.These compounds were extremely potent when tested in the rat passive cutaneous anaphylaxis (PCA assay either by the ip or the po route of administration).One of the sodium salts, oxoacetic acid sodium salt (11a, Wy-41 195), has ED50 value of 0.07 mg/kg po and has been selected for further evaluation.

Antisecretory oxamic acid esters

Variously substituted oxanilic acid esters possessing anti-secretory activity are useful anti-ulcer agents.

Antisecretory oxamic acid esters

Variously substituted oxanilic acid esters possessing anti-secretary activity are useful anti-ulcer agents.