6340-55-2

Basic information

• Product Name: 2,6-DIMETHOXY-4-METHYLQUINOLINE
• Synonyms: 2,6-DIMETHOXY-4-METHYLQUINOLINE;2-Chloro-6-methoxylepidine;Quinoline, 2-chloro-6-Methoxy-4-Methyl-
• CAS NO: 6340-55-2
• Molecular Formula: C₁₁H₁₀ClNO
• Molecular Weight: 207.66
• Mol File: 6340-55-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.287g/cm³
• Refractive Index: 1.621
• CAS DataBase Reference: 2,6-DIMETHOXY-4-METHYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIMETHOXY-4-METHYLQUINOLINE(6340-55-2)
• EPA Substance Registry System: 2,6-DIMETHOXY-4-METHYLQUINOLINE(6340-55-2)

Safety Data

• Hazardous Substances Data: 6340-55-2(Hazardous Substances Data)

Usage

Uses

2-Chloro-6-methoxy-4-methylquinoline is an intermediate in the synthesis of Tafenoquine-d3 Succinate which is the labelled analog of Tatenoquine (T004760), a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the prevention and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase.

InChI:InChI=1/C24H24N2O6/c1-4-7-16-12-15(14-20(21(16)27)32-6-3)13-19-22(28)25-24(30)26(23(19)29)17-8-10-18(11-9-17)31-5-2/h4,8-14,27H,1,5-7H2,2-3H3,(H,25,28,30)/b19-13+

Upstream product

• 5342-23-4 2-hydroxy-4-methyl-6-methoxyquinoline 
• 5437-98-9 4'-methoxyacetoacetanilide 
• 104-94-9 4-methoxy-aniline 
• 5342-23-4 6-methoxy-4-methyl-2-oxo-1H-quinoline 

Downstream Products

• 94960-01-7 4-(6-methoxy-4-methyl-quinolin-2-ylamino)-benzenesulfonamide 
• 52323-10-1 6-methoxy-4-methyl-quinoline-2-thiol 
• 359784-21-7 2-phenoxy-4-methyl-6-methoxyquinoline 
• 71509-00-7 2-(3',5'-dimethylpyrazol-1'-yl)-4-methyl-6-methoxyquinoline 
• 258521-45-8 6-methoxy-4-methyl-2-(4-methyl-2-nitroanilino)quinoline 
• 258521-46-9 6-methoxy-2-(4-methoxy-2-nitroanilino)-4-methylquinoline 
• 359784-25-1 2-phenoxy-6-methoxyquinoline-4-carbaldehyde 
• 359784-26-2 2-phenoxy-6-methoxyquinoline-4-carboxylic acid 
• 359784-27-3 2-phenoxy-6-methoxyquinoline-4-carbonyl chloride 
• 359784-28-4 4-(diazomethylene)carbonyl-2-phenoxy-6-methoxyquinoline 
• 359784-29-5 2-(6-methoxy-2-phenoxy-quinolin-4-yl)-acetamide 

Relevant articles and documents

Compounds having anticonvulsion activity, preparing methods thereof and applications of the compounds

The invention provides 7-substituted-5-methyl-1,2,4-triazolo[4,3-a] quinoline and 7-substituted-5-ethoxy-[1,2,4]-triazolo[4,3-a] quinoline compounds having anticonvulsion activity, preparing methods thereof and applications of the compounds in the field of preparing anticonvulsion medicines.

Quinoline-4-acetamides as sPLA2 inhibitors

Quinoline-4-acetamides were designed as potential phospholipase A2 inhibitors by structural based method and synthesized. The chemical structures of the obtained compounds were confirmed by elemental analyses, 1H NMR and MS. Preliminary bioassay study shows that quinoline-4-acetamides display certain inhibition to sPLA2.

Substituted thiosemicarbazido/semicarbazido quinolines as possible antimalarials

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