6346-09-4

Basic information

• Product Name: 4,4-Diethoxybutylamine
• Synonyms: 1-Butanamine, 4,4-diethoxy-;4,4-Diethoxy-1-butanamine;4-Aminobutyralodehyde diethyl ester;RARECHEM AL BW 2140;4-AMINOBUTYRALDEHYDE DIETHYL ACETAL;4,4-DIETHOXYBUTYLAMINE;GAMMA-AMINOBUTYRALDEHYDE DIETHYL ACETAL;4-AMINOBUTYRALDEHYDE DIETHYL ACETAL, TEC H., 90%
• CAS NO: 6346-09-4
• Molecular Formula: C₈H₁₉NO₂
• Molecular Weight: 161.24
• EINECS: 228-753-2
• Product Categories: API intermediates
• Mol File: 6346-09-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 196 °C(lit.)
• Flash Point: 145 °F
• Appearance: Clear colorless/Liquid
• Density: 0.933 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.408mmHg at 25°C
• Refractive Index: n20/D 1.428(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• PKA: 10.50±0.10(Predicted)
• Water Solubility: Miscible in water.
• Sensitive: Air Sensitive
• BRN: 1739649
• CAS DataBase Reference: 4,4-Diethoxybutylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-Diethoxybutylamine(6346-09-4)
• EPA Substance Registry System: 4,4-Diethoxybutylamine(6346-09-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 2735
• WGK Germany: 3
• F: 10-34
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 6346-09-4(Hazardous Substances Data)

Usage

Chemical Properties

clear colourless liquid

InChI:InChI=1/C8H19NO2/c1-3-10-8(11-4-2)6-5-7-9/h8H,3-7,9H2,1-2H3/p+1

Upstream product

• 143706-30-3 4,4-Diethoxy-3-hydroxybutyronitril 
• 10602-36-5 3-butenal 1,1-diethylacetal 
• 122-51-0 orthoformic acid triethyl ester 
• 1401564-75-7 2-(4,4-diethoxybutyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 13269-77-7 2,3-epoxy-1,1-diethoxypropane 
• 35573-93-4 3-chloro-1,1-diethoxy-propane 
• 117176-81-5 2-(phenyl)-N-(4,4-diethoxybutyl)acetamide 
• 26391-92-4 4,4-diethoxy-butyraldehyde oxime 
• 18381-45-8 4,4-diethoxybutanenitrile 

Downstream Products

• 110354-15-9 4-(2-Oxo-4,5-diphenyl-oxazol-3-yl)-butyraldehyde 
• 32464-55-4 2-(4,4-diethoxybutyl)isoindoline-1,3-dione 
• 1116-77-4 4,4-diethoxy-N,N-dimethyl-1-butanamine 
• 151692-61-4 N-(4,4-Diethoxybutyl)-2-iodobenzamide 
• 125541-21-1 4-(4,4-Diethoxy-butylamino)-piperidine-1-carboxylic acid tert-butyl ester 
• 101537-87-5 (E)-N-(4,4-diethoxybutyl)-2,3-bis-(3,4-dimethoxyphenyl)-acrylamide 
• 121910-30-3 [1-(4-Chloro-phenyl)-eth-(E)-ylidene]-(4,4-diethoxy-butyl)-amine 
• 125541-22-2 1-(tert-butoxycarbonyl)-4-phenylaminopiperidine 
• 121910-29-0 (4,4-Diethoxy-butyl)-[1-phenyl-eth-(E)-ylidene]-amine 
• 121910-31-4 (4,4-Diethoxy-butyl)-[1-phenyl-prop-(E)-ylidene]-amine 
• 113350-61-1 N-cinnamoylpyrrolidin-2-ol 
• 107979-52-2 (E)-N-(4,4-Diethoxy-butyl)-3-phenyl-acrylamide 
• 121378-55-0 (S)-N-(4,4-Diethoxybutyl)-2-hydroxy-3-phenylpropanamid 

Relevant articles and documents

Direct stereospecific amination of alkyl and aryl pinacol boronates

The direct amination of alkyl and aryl pinacol boronates is accomplished with lithiated methoxyamine. This reaction directly provides aliphatic and aromatic amines, stereospecifically, and without preactivation of the boronate substrate.

Hydrolysis and hydrogenolysis of formamidines: N,N-dimethyl and N,N- dibenzyl formamidines as protective groups for primary amines

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Domino reactions - New concepts in the synthesis of indole alkaloids and other polycyclic indole derivatives

2-Vinylindoles, which are easily accessible via a domino process, are useful synthons for a variety of applications. Subsequent Diels-Alder reactions yield tetrahydrocarbazoles which can be dehydrated to carbazoles such as derivatives of olivacine or elipticine. Cycloadditions with enamine intermediates lead to the synthesis of epidasycarpidone.