63480-11-5

Basic information

• Product Name: 4-METHYL-ISATOIC ANHYDRIDE
• Synonyms: 4-METHYL-ISATOIC ANHYDRIDE;7-METHYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE;REF DUPL: 4-Methyl-isatoic anhydride;2H-3,1-Benzoxazine-2,4(1H)-dione, 7-methyl-;7-methyl-1H-3,1-benzoxazine-2,4-dione
• CAS NO: 63480-11-5
• Molecular Formula: C₉H₇NO₃
• Molecular Weight: 177.16
• Mol File: 63480-11-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 228 °C (decomp)
• Appearance: /
• Density: 1.336g/cm³
• Refractive Index: 1.576
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 10.81±0.20(Predicted)
• CAS DataBase Reference: 4-METHYL-ISATOIC ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-ISATOIC ANHYDRIDE(63480-11-5)
• EPA Substance Registry System: 4-METHYL-ISATOIC ANHYDRIDE(63480-11-5)

Safety Data

• Hazardous Substances Data: 63480-11-5(Hazardous Substances Data)

Usage

General Description

4-Methyl-isatoic anhydride is a chemical compound with the molecular formula C9H5NO3. It is a derivative of isatoic anhydride, with a methyl group attached to the aromatic ring. 4-METHYL-ISATOIC ANHYDRIDE is used as a building block in organic synthesis and in the production of pharmaceuticals. It is known for its ability to react with amines, alcohols, and thiols to form amides, esters, and thioesters, making it a versatile reagent in chemical reactions. 4-Methyl-isatoic anhydride is also used as a dye intermediate and in the synthesis of other organic compounds, making it an important chemical in the field of organic chemistry.

InChI:InChI=1/C9H7NO3/c1-5-2-3-6-7(4-5)10-9(12)13-8(6)11/h2-4H,1H3,(H,10,12)

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 2305-36-4 4-methylanthranilic acid 
• 27329-27-7 4-methyl-2-nitrobenzoic acid 
• 75-05-8 acetonitrile 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 75-44-5 phosgene 
• 1128-47-8 6-methylindoline-2,3-dione 

Downstream Products

• 1228794-35-1 C₈H₁₁N₃O 
• 1201935-73-0 2-amino-N,4-dimethylbenzamide 
• 39549-79-6 2-amino-4-methylbenzamide 
• 15719-64-9 methylammonium carbonate 
• 2305-36-4 4-methylanthranilic acid 

Relevant articles and documents

New spiro pyrrole[2, 1-b]quinazolone derivative, preparation method and application thereof

The invention relates to a new spiro pyrrole[2, 1-b]quinazolone derivative, a preparation method and application thereof. The new spiro pyrrole[2, 1-b]quinazolone derivative is synthesized by using asimple method. The yield is high, the production cost is

Synthesis of Ring-Fused, N-Substituted 4-Quinolinones Using p Ka-Guided, Base-Promoted Annulations with Isatoic Anhydrides: Total Synthesis of Penicinotam

An anionic annulation strategy employing isatoic anhydrides and a wide assortment of enolizable partners was developed to afford over 80 novel ring-fused, N-substituted 4-quinolinones, an underrepresented privileged template. Multiple factors governing the efficiency of the transformation were determined, resulting in a reliable and tunable synthetic platform applicable for a broad range of substrates with variable deprotonation susceptibility, such as tetramic and tetronic acids, cyclic 1,3-diketones, and cycloalkanones. Application to the synthesis of bioactive, pyrrolizine-fused 4-quinolinone, penicinotam 3, resulted in the most brief and highest yielding total synthesis of the alkaloid in three steps and a 36% overall yield.

Catalytic Asymmetric Synthesis of Atropisomeric Quinolines through the Friedl?nder Reaction

A phosphoric acid catalyzed atroposelective Friedl?nder reaction was developed in which acetylacetone and a variety of 2′-substituted 2-Aminobenzophenones were successfully employed to give optically active biaryl quinolines in good yields and with high enantioselectivities.