637352-84-2

Basic information

• Product Name: 2-CHLORO-6-[4-(TRIFLUOROMETHYL)PHENYL]PYRAZINE
• Synonyms: 2-CHLORO-6-[4-(TRIFLUOROMETHYL)PHENYL]PYRAZINE;4-CHLORO-2-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDINE
• CAS NO: 637352-84-2
• Molecular Formula: C₁₁H₆ClF₃N₂
• Molecular Weight: 258.63
• Mol File: 637352-84-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CHLORO-6-[4-(TRIFLUOROMETHYL)PHENYL]PYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-[4-(TRIFLUOROMETHYL)PHENYL]PYRAZINE(637352-84-2)
• EPA Substance Registry System: 2-CHLORO-6-[4-(TRIFLUOROMETHYL)PHENYL]PYRAZINE(637352-84-2)

Safety Data

• Hazardous Substances Data: 637352-84-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-6-[4-(trifluoromethyl)phenyl]pyrazine is used as an intermediate in the synthesis of various organic compounds for pharmaceutical applications. Its unique molecular structure contributes to the development of new drugs with potential therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-6-[4-(trifluoromethyl)phenyl]pyrazine is utilized as a building block for the creation of new agrochemicals, potentially enhancing crop protection and yield.
Used in Materials Science:
2-Chloro-6-[4-(trifluoromethyl)phenyl]pyrazine is employed in materials science for the development of novel materials with specific properties, such as improved stability or reactivity, due to its distinctive molecular structure.

Upstream product

• 4774-14-5 2,6-dichloropyrazine 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 850221-68-0 2-chloro-6-(tri-n-butylstannyl)pyrazine 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 

Downstream Products

• 952710-94-0 2-(4-trifluoromethyl-phenyl)-6-vinyl-pyrazine 
• 637352-90-0 ethyl {4-[((2-methoxyethyl){6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}amino)methyl]-2-methylphenoxy}acetate 
• 637352-88-6 ethyl {4-[(butyl{6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}amino)methyl]-2-methylphenoxy}acetate 
• 637353-24-3 ethyl {2-ethyl-4-[((2-methyloxyethyl){6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}amino)methyl]phenoxy}acetate 
• 637353-23-2 ethyl {4-[(butyl{6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}amino)methyl]-2-ethylphenoxy}acetate 
• 637352-86-4 2-bromo-6-[4-(trifluoromethyl)phenyl]pyrazine 

Relevant articles and documents

Palladium-catalyzed cross-coupling of aroyl chlorides with aryl stannanes in the presence of triethylsilane: Efficient access to aromatic ketones

Herein, we report the development of a palladium-catalyzed cross-coupling reaction that focuses on the preparation of aromatic ketones. Aroyl chlorides react quickly at 120 °C with aryl stannanes in the presence of Pd(PPh3)4 and Et3SiH to efficiently give the corresponding ketones without the formation of significant decarbonylated byproducts. In other words, the decarbonylative side reaction is practically suppressed by simply adding Et3SiH to the reaction mixture, which reduces the amount of biaryl impurities in the products.

NOVEL HETEROCYCLIC COMPOUNDS AS ANTIMALARIAL AGENTS

The invention relates to novel heterocyclic compounds of the Formula I. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of the Formula I and

BENZOAZEPIN-OXY-ACETIC ACID DERIVATIVES AS PPAR-DELTA AGONISTS USED FOR THE INCREASE OF HDL-C, LOWER LDL-C AND LOWER CHOLESTEROL

The invention is directed to compounds of Formula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndr

CHEMICAL COMPOUNDS

A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, .Wherein:R1 and R2 are independently hydrogen or C1-3 alkyl;X represents a bond, CH2 or O;R3 and R4 are independently hydrogen, C1-6 alkyl, OCH3, CF3, allyl or halogen;X1 is CH2, SO2, or CO;R5 is -C1-6 alkyl (optionally substituted by C1-6alkoxy or C1-6alkylthio), -C2-6 alkenyl, -C0-6 alkyl phenyl (wherein the phenyl is optionally substituted by one or more CF3, halogen, C1-3 alkyl, C1-3 alkoxy), -COC1-6 alkyl, SO2C1-6 alkyl ;R6 is phenyl or a 6 membered heteroaryl group containing 1,2 or 3 N atoms wherein the phenyl or heteroaryl group is optionally substituted with 1, 2 or 3 moieties selected from the group consisting of C1-6 alkyl, halogen, -OC1-6 alkyl, -SO2C1-3 alkyl, phenyl (optionally substituted by one or more groups selected from halogen, CF3, C1-3 alkyl, OC1-3 alkyl, acetyl, CN).